DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo3 and Igsf9b

DIOPT Version :9

Sequence 1:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	194/840 - (23%)
Similarity:	296/840 - (35%)	Gaps:	219/840 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AQGSHPPRIVEHPIDTTVPRHEPATLNC----KAEGSPTP-TIQWYKDGVPLKIL---------- 66
            ||.:|..|  |.|...|....|...|.|    ...|.|.| .::|:|.|||:.|.
  Rat    20 AQVAHGLR--EEPEFVTARAGEGVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHV 82

  Fly    67 --PGSHRITLPAGGLFFLKVVNSRRETDAGIYWCEAKNELGVARSRNATLQVAVLRDEF------ 123
              ..:.|.:|.......|:.|   |..|.|.|.|:             .|.:....|.|
  Rat    83 DPEYAGRASLHDKASLRLEQV---RSEDQGWYECK-------------VLMLDQQYDTFHNGSWV 131

  Fly   124 -----------RLEPQNTRIAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRIVDGGN 177
                       ...||.....:|.:..:.|.| .|.|:|.|||.|.|..|...|..:   |..|:
  Rat   132 HLTINAPPTFTETPPQYIEAKEGGSITMTCTA-FGNPKPIVTWLKEGTLLSASGKYQ---VSDGS 192

  Fly   178 LAIQDARQTDEGQYQCIAKNPVGVRESSLAT-LKVHVKPYIIRGPHDQTVLEGASVTFPCRVGGD 241
            |.:....:.|.|.|.|.|.:..|  |:...| |.|...|:|:..|.:.||.........||....
  Rat   193 LTVTSVSREDRGAYTCRAYSIQG--EAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAY 255

  Fly   242 PMPDVLWLRTASGGNMPLD----------------RVSVLEDRSLRLERVTIADEGEYSCEADNV 290
            |            ||:...                ||.:|.|.:|.:.||...|.|:|:|...|.
  Rat   256 P------------GNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGKYTCVPSNS 308

  Fly   291 VG-AITAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIF---------------- 338
            :| :.:|...|||..|.:.:..|....|.:|......|.....|..|:.
  Rat   309 LGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLG 373

  Fly   339 WTIKNNSTLIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVA-SITSRVQLS 402
            ||:..:.::....|          |||.....|...:           |.:..:. |..:|:.|
  Rat   374 WTLMEDGSIRIEEA----------TEEALGTYTCVPY-----------NTLGTMGQSAPARLVL- 416

  Fly   403 LDSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSSKLNITTSGDLI 467
                :|.|...::.|...:....:.| .:.|.|.|.|.|.|:|.:.|.|.:  ||.|...||.|.
  Rat   417 ----KDPPYFTVLPGWEYRQEAGREL-LIPCAAAGDPFPVITWRKVGKPSR--SKHNALPSGSLQ 474

  Fly   468 ISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATA 532
            ...|.: :|.|.:.|||::.....|.|..|.: :.|:|:              |||..:: :.:.
  Rat   475 FRALSK-EDHGEWECVATNVVTSITASTHLTV-IGTSPH--------------APGSVRV-HVSM 522

  Fly   533 SALTIVW-PTSDKAGASSFLGYSVEMYCTNQ--SRTWIPIASRLSEPIFTVESLTQGAAYMFIVR 594
            :...:.| |..|.....:|..:...:....|  ...|:.::..|......|:||....||.|.|.
  Rat   523 TTANVSWEPGYDGGYEQTFSVWYGPLMKRAQFGPHDWLSLSVPLGPSWLLVDSLEPETAYQFSVL 587

  Fly   595 AENSLGFSPPSPISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVE--LLEANASDST 657
            |:|.||   .|..||.:|...|     ....|....|:|......|.||...:  ||    |...
  Rat   588 AQNRLG---TSAFSEVVTVNTL-----AFPVTTPEPLVLVTPPRCLTANRTQQGVLL----SWLP 640

  Fly   658 TARLSWDIDSGQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPG---------LAKASTYE 713
            .|..|:.||  :||..|.:..|      ::|:          ...:||         |::.:.||
  Rat   641 PANHSFPID--RYIMEFRVGER------WEML----------DDAIPGTDGEFFAKDLSQDTWYE 687

  Fly   714 FFLVPFYKSIVGKPSNSRRMRTLEDVPEAPPYGMEAIQFNRTSVFLKWLPPQPNRTRNGI 773
            |.::...:.::.:|||...:                   :.|.:|     |||:.|.:|:
  Rat   688 FRVLAVMQDLISEPSNIAGV-------------------SSTDIF-----PQPDLTDDGL 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo3	NP_608592.2	Ig	22..117	CDD:299845	26/111 (23%)
		I-set	23..116	CDD:254352	26/109 (24%)
		I-set	122..211	CDD:254352	28/106 (26%)
		Ig	125..211	CDD:299845	27/86 (31%)
		I-set	215..302	CDD:254352	25/103 (24%)
		Ig	232..302	CDD:299845	20/86 (23%)
		I-set	306..401	CDD:254352	16/111 (14%)
		Ig	320..411	CDD:299845	16/107 (15%)
		I-set	412..492	CDD:254352	23/79 (29%)
		IGc2	429..489	CDD:197706	21/59 (36%)
		FN3	519..612	CDD:238020	24/95 (25%)
		FN3	644..735	CDD:238020	21/101 (21%)
		fn3	743..832	CDD:278470	7/31 (23%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	20/89 (22%)
		I-set	139..225	CDD:369462	27/91 (30%)
		Ig	229..321	CDD:386229	25/103 (24%)
		Ig	<353..414	CDD:386229	10/81 (12%)
		Ig	438..502	CDD:319273	24/67 (36%)
		FN3	510..605	CDD:238020	26/112 (23%)
		FN3	621..703	CDD:238020	22/103 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000