DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo3 and Fas2

DIOPT Version :9

Sequence 1:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	838	Identity:	201/838 - (23%)
Similarity:	305/838 - (36%)	Gaps:	226/838 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VFIVFLL------KWTHAQGSHPPRIVEHPIDTTVPRHE--------PATLNCK---AEGSPTPT 53
            ||:..||      :.|.||.         ||....|:.|        |..|.|:   .|.|....
  Fly    11 VFLALLLCSCSLIELTRAQS---------PILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVAD 66

  Fly    54 IQWYKDGVPLKIL--------PGSHRITLPAGGLFFLKVVNSRRETDAGIYWCEAKNELGVARSR 110
            :|| ||.....||        |..:..|||...|..:  :.|......|.|:|.|.........:
  Fly    67 LQW-KDNRNNTILPKPNGRNQPPMYTETLPGESLALM--ITSLSVEMGGKYYCTASYANTEILEK 128

  Fly   111 NATLQ--VAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRIV 173
            ..|::  ||:   .:...|:|.....|...::.|.. :..|.||:.|.:.|..:.....|.|  |
  Fly   129 GVTIKTYVAI---TWTNAPENQYPTLGQDYVVMCEV-KADPNPTIDWLRNGDPIRTTNDKYV--V 187

  Fly   174 DGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVHV--KPYIIRGPHDQTVLEGASVTFPC 236
            ....|.|::.:::|||.|.|.|. .:...|....|::|.|  :|.||..|.:...:||......|
  Fly   188 QTNGLLIRNVQESDEGIYTCRAA-VIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANC 251

  Fly   237 RVGGDPMPDVLWLRTASGGNM-PLDRVSVLEDRSLRLERVTIA-----DEGEYSCEADNVVGAIT 295
            ...|.|:|::.|:|.|:..|: ..||..|.....|    |||:     |.|.|:|.|.|..|.:.
  Fly   252 TARGKPVPEISWIRDATQLNVATADRFQVNPQTGL----VTISSVSQDDYGTYTCLAKNRAGVVD 312

  Fly   296 AMGTLTVYAPPKFIQRPASKSVEL----GADT---SFECRAIGNPKPTIF---WTIKNNST---- 346
            ....|.|...|:.        .||    ||.|   :..|||.|.|.|.|.   |..:...|
  Fly   313 QKTKLNVLVRPQI--------YELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQ 369

  Fly   347 ------LIFPGAPPLDRFHSLNTEEGHS--ILTLTRFQRTDKDLVILCNAMNEVAS------ITS 397
                  ::.|         :.:.|.|.|  .|.::..:|:| |.:..|.|.|:.|.      ||
  Fly   370 DDDPRIILEP---------NFDEERGESTGTLRISNAERSD-DGLYQCIARNKGADAYKTGHIT- 423

  Fly   398 RVQLSLDSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQP--SSKLNI 460
             |:.:.|....:..|.:.|....:       |.|.|.|:|:|:.||.|:.:|..::.  .:.|.|
  Fly   424 -VEFAPDFSHMKELPPVFSWEQRK-------ANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKI 480

  Fly   461 TTSG---DLIISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAP 522
            ..:|   |||:..:.||...| |.|:|::..|.:          ..:..:|..|.|:
  Fly   481 VGTGPRSDLIVHPVTRQYYSG-YKCIATNIHGTA----------EHDMQLKEARVPD-------- 526

  Fly   523 GQPKILNATASALTIVWPTSDKAGASSFLG-----YSVEM-------YCTNQSRTWIPIASRLSE 575
               .:..|..|.||....|.|..|.|:.||     |||:.       :.|..:|:|.|      :
  Fly   527 ---FVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSP------D 582

  Fly   576 PIFTVESLTQGAAYMFIVRAENSLGF-----------------SPPSPISEPITAGKLVGV---- 619
            ..:.||.|.....|.|...|.|.:|.                 ..|.|:..|:...|...|
  Fly   583 SPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSP 647

  Fly   620 ------------RDGSESTGTSQL------LLSDVETLLQAN-DVVELLEANASDSTTARLSWDI 665
                        .|..|.....|:      .:|...|.|:.: :.||::|..:.:.|
  Fly   648 YSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMT-------- 704

  Fly   666 DSGQYIEGFYLYAREL-------HSSEYKMVTLLNKG---------QGLSSCTVPGLA 707
               |.:...| |..||       :||...::....:|         |..||..:.|:|
  Fly   705 ---QLVGNTY-YRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIA 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo3	NP_608592.2	Ig	22..117	CDD:299845	26/115 (23%)
		I-set	23..116	CDD:254352	26/113 (23%)
		I-set	122..211	CDD:254352	22/88 (25%)
		Ig	125..211	CDD:299845	22/85 (26%)
		I-set	215..302	CDD:254352	29/92 (32%)
		Ig	232..302	CDD:299845	23/75 (31%)
		I-set	306..401	CDD:254352	30/122 (25%)
		Ig	320..411	CDD:299845	28/114 (25%)
		I-set	412..492	CDD:254352	25/84 (30%)
		IGc2	429..489	CDD:197706	22/64 (34%)
		FN3	519..612	CDD:238020	28/121 (23%)
		FN3	644..735	CDD:238020	17/80 (21%)
		fn3	743..832	CDD:278470
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	23/96 (24%)
		IG_like	144..226	CDD:214653	23/85 (27%)
		IGc2	152..209	CDD:197706	17/59 (29%)
		I-set	230..319	CDD:254352	29/92 (32%)
		IGc2	243..309	CDD:197706	23/69 (33%)
		IG_like	330..424	CDD:214653	26/105 (25%)
		IGc2	339..412	CDD:197706	19/82 (23%)
		Ig	447..518	CDD:143165	23/81 (28%)
		fn3	534..611	CDD:278470	24/82 (29%)
		FN3	640..735	CDD:238020	18/106 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840