DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo3 and Prtg

DIOPT Version :9

Sequence 1:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_780694.3	Gene:	Prtg / 235472	MGIID:	2444710	Length:	1191	Species:	Mus musculus

Alignment Length:	1290	Identity:	295/1290 - (22%)
Similarity:	448/1290 - (34%)	Gaps:	367/1290 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRITLPAGGLFFLKVVNSRR- 89
            ::.|.|.||.|.:|..|:|:|.|.....:.|.|:|..|.   .:.||.:.:.|..::..|..||
Mouse    36 MKEPQDATVTRKDPVVLDCQAHGEGPIKVTWLKNGAKLS---ENKRIQVLSNGSLYISEVEGRRG 97

  Fly    90 -ETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPTV 153
             ::|.|.|.|.|.|:.|...|:.|.|.::.: ..|.:.|.:|.:.:|..|...|.. ...|...:
Mouse    98 EQSDEGFYQCLAVNKYGAILSQKAHLTLSTI-SAFEVHPVSTEVHEGGVARFSCKI-SSTPPAVI 160

  Fly   154 TWKKGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKV------- 211
            ||:.....|... ..||..:..|.|.|.|....|.|.|:|:|......|:|..|:|.:
Mouse   161 TWEFNRTALPTT-MDRVTALPSGVLQIYDVGPEDAGNYRCVAATIAHKRKSMEASLTIVAANETR 224

  Fly   212 -HVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVS-------VLEDR 268
             ...|.||..|.:.|.....:|...|...|.|.|.:.|.|        ||..|       ||.:.
Mouse   225 SFYMPTIIASPQNVTASLHQTVVLECMATGYPRPIISWSR--------LDHKSIDVFNTRVLGNG 281

  Fly   269 SLRLERVTIADEGEYSCEA--DNVVGAITAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIG 331
            :|.:..|.:...|.|.|.|  ........||.||||.|||.|::.|.|.:........|.|:|.|
Mouse   282 NLIISDVKLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEG 346

  Fly   332 NPKPTIFWTIKNNSTLIFPGAPPLDRFHSLNTEEG-----HSILTLTRFQRTDKDLVILCNAMNE 391
            .|.|.:.| :||..           |.||    .|     :|.|.:.:....| |.:..|.|.|.
Mouse   347 IPSPKMSW-LKNGR-----------RIHS----NGRIKMYNSKLVINQIIPED-DAIYQCMAENS 394

  Fly   392 VASITSRVQLSLDSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSS 456
            ..|:.||.:|::...||||     |.|.|     ....|:...||     .::|.|   |:..|.
Mouse   395 QGSVLSRARLTVVMSEDRP-----SAPYN-----VHAETMSSSAI-----LLAWER---PLYNSD 441

  Fly   457 KL-----------------------NITTSGDLIISDLDRQQDQGLYTCV--------------- 483
            |:                       |.||  ..||.||:...:...|...
Mouse   442 KVIAYSVHYMKAEGLNNEEYQVVLGNDTT--HYIIDDLEPDSNYTFYIVAYMPLGASQMSDHVTQ 504

  Fly   484 -------------------------------ASSRAGK----------STWSGFLRIELP----- 502
                                           |..|.|:          ||.:....:|||
Mouse   505 NTLEDVPLRPPEISLTSRSPTDILVSWLPIPAKYRRGQVVLYRLSFRLSTENAIQVVELPGTVHE 569

  Fly   503 -----TNPNIKF--------------------YRAPEQTKCPSAPGQPKI----LNATASALTIV 538
                 ..|:..:                    :|.|:.|.. .||..|::    ||.|..::..:
Mouse   570 YLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSV-KAPKSPELHLEPLNCTTISVRWL 633

  Fly   539 WPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSL--GF 601
            ..|.|.|   :..||.: .|.....:...||.....:.::|:..|.....|...:.|.|::  |:
Mouse   634 QDTEDPA---AIRGYKL-FYKEEGQQEHGPIFLDTGDLLYTLSGLDPRRKYHVRLLAYNNMEEGY 694

  Fly   602 SPPSPISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTARLSW--- 663
            .....:|.|    ..|.|||                .::........|.|.|:.|::..|.|
Mouse   695 QADQTVSTP----GCVSVRD----------------RMVPPPPPPHHLYAKANTSSSIFLHWRRP 739

  Fly   664 DIDSGQYIE-------------GFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYEFF 715
            ...:.|.|.             ...||   |.:||..|:             |.||...:.|| |
Mouse   740 AFTTAQVINYTIRCNPVGLQNASLVLY---LQTSETHML-------------VQGLEPNTKYE-F 787

  Fly   716 LVPFYKSIVGKP-SNSRRMRTLEDVPEAPPYGMEAIQFNRTSVFLKWLPPQPNRTRNGILTSYNV 779
            .|..:...:..| |......||.:.|..||.|::.......:..:.|.||....|   ::|.|.:
Mouse   788 AVRLHVDQLSSPWSPVVYHSTLPEAPTGPPVGVKVTLIEDDTALVSWKPPDGPET---VVTRYTI 849

  Fly   780 VVKGLD---------VHNTTRIFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKP- 834
            :.....         :|.          :.|....||.||..|..|.:.::|:..||.||||..
Mouse   850 LYASRKAWIAGEWQVLHR----------EGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSV 904

  Fly   835 --AVL------------RIDARTQSLDTGYTRYPISRDIADDFLTQTWFIVLLGSIIAIIVFLLG 885
              |||            |:|:....:.:||  |.:      |..:.|...|.:|  ||:...|:.
Mouse   905 ELAVLPKDASESNQRPKRLDSSNAKVYSGY--YHL------DQKSMTGIAVGVG--IALTCILIC 959

  Fly   886 ALVLFKRYQFIKQTSLGSLHGNHAIGTVRKFPTLPLNGGGA-VGAG---GSNSTAAAGQSGHGLW 946
            .|:|..|.:..|.::..:....          |.||:...| |.||   |.|...|...:...:.
Mouse   960 VLILIYRSKARKSSASKTAQSG----------TQPLSQASASVAAGSDMGKNLERATETAESLVP 1014

  Fly   947 IDPTSGVWRQAAGGG----NPGG--VGSCTTKEQLPGYAQAT----AQQGQQPTLLPDYERLSPL 1001
            :.|:|.:  .|.||.    |..|  :.:.|.|:.|  :.|.|    .:|.|:
Mouse  1015 MMPSSFI--DAKGGTDLIINSYGPIIKNNTKKKWL--FFQDTKKIKVEQTQR------------- 1062

  Fly  1002 NMPDYAEVAC-----STFKSPTHGAPPMGGGGGGQSASLYDSCGAYA-TTNVVANVKLYQNRYAT 1060
               .:.:..|     :|.......:|    |..||:||.....||.| .|...||        :.
Mouse  1063 ---RFTQAVCFYQPGTTVLISDEDSP----GSPGQTASFPRPFGATALDTEHSAN--------SE 1112

  Fly  1061 KPNQSSGSNNNNHQGND--YQSTGMYSAPPSAH-------YGCLEPKQQQQQQQP 1106
            ..:::..|...:|:.||  :.|:.:.|.||:::       .|...||:.....||
Mouse  1113 GSHETGDSGRFSHESNDEIHLSSVISSTPPTSNPLAGGDSDGDAAPKKHGDPAQP 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo3	NP_608592.2	Ig	22..117	CDD:299845	30/92 (33%)
		I-set	23..116	CDD:254352	30/91 (33%)
		I-set	122..211	CDD:254352	25/88 (28%)
		Ig	125..211	CDD:299845	24/85 (28%)
		I-set	215..302	CDD:254352	27/95 (28%)
		Ig	232..302	CDD:299845	22/78 (28%)
		I-set	306..401	CDD:254352	27/99 (27%)
		Ig	320..411	CDD:299845	27/95 (28%)
		I-set	412..492	CDD:254352	22/158 (14%)
		IGc2	429..489	CDD:197706	18/128 (14%)
		FN3	519..612	CDD:238020	22/98 (22%)
		FN3	644..735	CDD:238020	23/107 (21%)
		fn3	743..832	CDD:278470	22/97 (23%)
Prtg	NP_780694.3	Ig	34..124	CDD:299845	29/90 (32%)
		I-set	35..125	CDD:254352	30/91 (33%)
		IG_like	135..217	CDD:214653	24/83 (29%)
		Ig	146..201	CDD:143165	16/56 (29%)
		IG_like	235..317	CDD:214653	24/89 (27%)
		IGc2	244..303	CDD:197706	18/66 (27%)
		I-set	321..406	CDD:254352	28/101 (28%)
		Ig	339..406	CDD:299845	24/83 (29%)
		FN3	413..506	CDD:238020	20/112 (18%)
		FN3	511..604	CDD:238020	9/92 (10%)
		FN3	613..693	CDD:238020	18/83 (22%)
		FN3	720..808	CDD:238020	23/104 (22%)
		FN3	815..905	CDD:238020	24/102 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	975..1010		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1191		25/101 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910