DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo3 and Igdcc3

DIOPT Version :9

Sequence 1:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001344186.1	Gene:	Igdcc3 / 19289	MGIID:	1202390	Length:	813	Species:	Mus musculus

Alignment Length:	926	Identity:	211/926 - (22%)
Similarity:	317/926 - (34%)	Gaps:	278/926 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRITLPAGGLFF--LKVVNSRRET 91
            |.|......:|..|.||.||:|...:.|.|:|..|.  .|:|...|..|.|..  .::......:
Mouse    60 PNDDIANPGQPIVLGCKVEGTPPVQVSWRKNGAELP--EGTHTTLLANGSLLIHHFRLEQGGSPS 122

  Fly    92 DAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPTVTWK 156
            |.|.|.|.|:|..|:..||.|.||.|.:.| |.:.||.....:|..|..:|.. .|:|:|.:||:
Mouse   123 DEGDYECVAQNRFGLLVSRKARLQAATMSD-FHVHPQAVTGEEGGVARFQCQI-HGLPKPLITWE 185

  Fly   157 KGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKV-------HVK 214
            |....:|.: .:|..::..|.|.|...|..|.|.:.|:|.|...||.|..|.|.|       :.:
Mouse   186 KNRVPIDTD-DERYTLLPKGVLQITGLRAEDSGIFHCVASNIASVRVSHGARLTVSGSGSGTYKE 249

  Fly   215 PYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIAD 279
            |.|:.||.:.|:....:....|...|:|.|.|.|.| ..|..:.::.:.||...:|.:..||:..
Mouse   250 PTILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR-LDGRPIGVEGIQVLGTGNLIISDVTVQH 313

  Fly   280 EGEYSCEADNVVGAI--TAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIK 342
            .|.|.|.|:.....:  ||.|.|.|.||.:|:|.|.|.|...|....|.|:|.|.|.|.:.| :|
Mouse   314 SGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTW-LK 377

  Fly   343 NNSTLIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSLDSQE 407
            |...|   ||            .||                               |:|..::
Mouse   378 NGQVL---GA------------GGH-------------------------------VRLKNNN-- 394

  Fly   408 DRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSSKLNITTSGDLIISDLD 472
                                 :||....:|
Mouse   395 ---------------------STLSISGVG----------------------------------- 403

  Fly   473 RQQDQGLYTCVASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASALT- 536
             .:|:.:|.|||.:.||.|..|..|.:                ......||.|:.:.|.:.:.|
Mouse   404 -PEDEAIYQCVAENIAGSSQASARLTV----------------LWAEGLPGPPRNVRAVSVSSTE 451

  Fly   537 --IVWPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIF--TVESLTQGAAYMFIVRAEN 597
              :.| :...|.....:||.:.:.....|.. :.....:|:..|  .|..|....||.|.::|..
Mouse   452 VRVSW-SEPLAHTKEIIGYVLHIRKAADSPK-LEYQEAVSKSTFQHLVRDLEPSTAYSFYIKAYT 514

  Fly   598 SLGFSPPS-----------PISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVELLEA 651
            ..|.|..|           |:..|::. :|:|       :.:.|||......|.|.|.
Mouse   515 PRGASLASVPTLASTLGEAPVPPPLSV-RLLG-------SSSLQLLWKPWPRLAQHNG------- 564

  Fly   652 NASDSTTARLSWDIDSGQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYEFFL 716
                                 ||.|:.|.:.::.:....|| .|. :||..:..|..::.||..|
Mouse   565 ---------------------GFKLFYRPVSATSFTGPILL-PGT-VSSYNLSQLDPSTVYEVKL 606

  Fly   717 VPFYKSIVGKPSNSRRMRTLEDVPE----APP----------------------YGMEAIQF--- 752
            :.:.:.  |..:.:.|..:|:...|    .||                      .|:..|.|
Mouse   607 LAYNQH--GDGNATVRFVSLKGASERTALTPPCDCRKEDVTNHTSTTGIVIGIHIGVTCIIFCVL 669

  Fly   753 -----NRTSVFL------KWLPPQPNRTRN--GILTSYNVVVKG-----------LDVHNTTRIF 793
                 .|..|.|      :..|||..|::.  ||| :.|.:.:|           :|.....::|
Mouse   670 FLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGIL-ALNGLSRGEGGQLSRDEKPVDAKELEQLF 733

  Fly   794 K---------NMTIDAAAPT-----------LLLANLTTGVTYYIAVAAATRVGVGPFSKPAVLR 838
            .         :...|.|||.           |...||..|.|   ..|.:...|.||...|.
Mouse   734 PTAGSAAQPGSTPTDPAAPAPCEETQLSMVQLQGFNLVAGRT---TEATSPCAGPGPVPAPQ--- 792

  Fly   839 IDARTQSLDTGYTRYP 854
             |.....|..|.|:.|
Mouse   793 -DIGPVPLSEGQTQPP 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo3	NP_608592.2	Ig	22..117	CDD:299845	30/89 (34%)
		I-set	23..116	CDD:254352	29/88 (33%)
		I-set	122..211	CDD:254352	28/88 (32%)
		Ig	125..211	CDD:299845	27/85 (32%)
		I-set	215..302	CDD:254352	26/88 (30%)
		Ig	232..302	CDD:299845	21/71 (30%)
		I-set	306..401	CDD:254352	21/94 (22%)
		Ig	320..411	CDD:299845	17/90 (19%)
		I-set	412..492	CDD:254352	10/79 (13%)
		IGc2	429..489	CDD:197706	8/59 (14%)
		FN3	519..612	CDD:238020	23/108 (21%)
		FN3	644..735	CDD:238020	15/90 (17%)
		fn3	743..832	CDD:278470	32/157 (20%)
Igdcc3	NP_001344186.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Ig	56..147	CDD:325142	29/88 (33%)
		Ig	158..239	CDD:325142	26/82 (32%)
		Ig_3	250..321	CDD:316449	21/71 (30%)
		I-set	343..429	CDD:254352	35/191 (18%)
		FN3	436..529	CDD:238020	21/94 (22%)
		fn3	<556..615	CDD:306538	17/90 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..724		9/35 (26%)
		DNA_pol3_gamma3	<690..>812	CDD:331207	30/126 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..813		11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4222
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810