DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo3 and Robo4

DIOPT Version :9

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:NP_001292144.1 Gene:Robo4 / 100911068 RGDID:727947 Length:1021 Species:Rattus norvegicus


Alignment Length:777 Identity:192/777 - (24%)
Similarity:291/777 - (37%) Gaps:191/777 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 PPRIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKI-LPGSHRITLPAGGLFFLKVV 85
            ||:|:.||.|..:....||.::|:|.|.|.|||:|..:|.||.: .|..|.:......|......
  Rat    41 PPQILVHPQDQLLQGSGPAKMSCRASGQPLPTIRWLLNGQPLSMATPDLHYLQSDGTLLLHRPPT 105

  Fly    86 NSRRETD-------AGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECA 143
            :.|.:.|       .|:|.|||.|.||.|.||.|.|.||||:::||::|::|....|::.:|||.
  Rat   106 HGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFRIQPRDTVAVVGESLVLECG 170

  Fly   144 APRGIPEPTVTWKKGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLAT 208
            .|.|.|:|:|:|.|.|:.|.|:..||.  |.|.:|.:..|.:.|.|.|.|:|.|..|.|||..|.
  Rat   171 PPWGYPKPSVSWWKDGKPLVLQPGKRT--VSGDSLMVARAEKNDTGTYMCMATNNAGQRESRAAR 233

  Fly   209 LKVHVKPYIIRGPHDQTV--------LEGASVTFPCRVGGDPMPDVLWLR-TASGGNMPLDRVSV 264
            :.:...|     .|.:.:        ||..::..|..|.|......:||. ..||...|....:.
  Rat   234 VSIQESP-----DHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPAVWLSWKVSGPAAPAQSYTA 293

  Fly   265 LEDRSLRLERVTIADEGEYSCEA--DNVVGAITAMGTL--------------------------- 300
            |    .|.:| ...|:|....|.  |.::.|  .:|.|                           
  Rat   294 L----FRAQR-DPRDQGSPWTEVLLDGLLNA--KLGGLRWGQDYEFKVRPSSGRARGPDSNVLLL 351

  Fly   301 -----TVYAPPKFIQ-RPASKSVEL-----------GADTSFECRAIGNPK-PTIFWTIKNNSTL 347
                 ...|||:.:. ||.:.||.:           |....::..::||.. |...||:....|.
  Rat   352 RLPEQVPSAPPQEVTLRPGNGSVFVSWAPPPAENHNGFIRGYQVWSLGNASLPAANWTVVGEQTQ 416

  Fly   348 I-----FPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSR-VQLSLDSQ 406
            :     .||:..:..........|...:.:         .::|..||.:.|...|: |..:|:..
  Rat   417 LEIAARMPGSYCVQVAAVTGAGAGEPSIPV---------CLLLEQAMEQSARDPSKHVSWTLEQL 472

  Fly   407 ED--RPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYR---DGIPVQPSSKLNITTSGDL 466
            ..  :.|.:|.||.|...|.:..:|             :..||   .|:.:.|.  |...||.|.
  Rat   473 RATLKRPEVIASGAVLLWLLLLGIA-------------VCIYRRRKAGVHLGPG--LYRYTSEDA 522

  Fly   467 IISD-LDRQQDQGL--------------YTCVASSRAG--------------------------- 489
            |:.. :|......|              .:...|||.|                           
  Rat   523 ILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGVDPRDPLDGRRSLISWDPRSPGVPLLP 587

  Fly   490 -KSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASALTIVWPTSDKAGASSFLGY 553
             .||:.|.|..|..::|.:   |...||  |:|...|..|..|:|.    |.:||  ...|..|.
  Rat   588 DTSTFYGSLIAEQTSSPPV---RPSPQT--PAARRLPPKLTGTSSP----WASSD--SLCSRRGL 641

  Fly   554 SVEMYCTNQSRTWIPIASRLSEPIFTVES--LTQGAAYMFI------VRAENSLGFSPP----SP 606
            .........:..|   .::..:.:....|  |.:|:..|.|      .||..:|..||.    ||
  Rat   642 CSPRMSLAPAEAW---KAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNTCSP 703

  Fly   607 ISEP--ITAGKLVGV---RDGSESTG----TSQLLLSDVETLLQANDVVELLEANASDSTTA 659
            ...|  :.|.:.:|.   |:.||...    .:.|.|....:....:..||.|:|.:||...|
  Rat   704 REAPGAVVAWRALGPQLHRNSSELAARPLPPTPLSLRGAPSHDPQSQCVEKLQAPSSDPLPA 765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 22..117 CDD:299845 37/102 (36%)
I-set 23..116 CDD:254352 36/100 (36%)
I-set 122..211 CDD:254352 35/88 (40%)
Ig 125..211 CDD:299845 33/85 (39%)
I-set 215..302 CDD:254352 22/129 (17%)
Ig 232..302 CDD:299845 18/104 (17%)
I-set 306..401 CDD:254352 21/113 (19%)
Ig 320..411 CDD:299845 17/99 (17%)
I-set 412..492 CDD:254352 21/125 (17%)
IGc2 429..489 CDD:197706 15/77 (19%)
FN3 519..612 CDD:238020 25/106 (24%)
FN3 644..735 CDD:238020 7/16 (44%)
fn3 743..832 CDD:278470
Robo4NP_001292144.1 Ig 41..144 CDD:299845 37/102 (36%)
I-set 42..143 CDD:254352 36/100 (36%)
I-set 150..231 CDD:254352 34/82 (41%)
Ig 152..236 CDD:299845 33/85 (39%)
fn3 275..346 CDD:278470 15/77 (19%)
fn3 361..443 CDD:278470 16/81 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..563 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..634 13/44 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 726..810 10/40 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 81 1.000 Domainoid score I8282
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
32.860

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