DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo3 and robo2

DIOPT Version :9

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_031752453.1 Gene:robo2 / 100493913 XenbaseID:XB-GENE-980527 Length:1620 Species:Xenopus tropicalis


Alignment Length:1540 Identity:442/1540 - (28%)
Similarity:669/1540 - (43%) Gaps:320/1540 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FVFIVFLL-------KWTHAQGSH------------PPRIVEHPIDTTVPRHEPATLNCKAEGSP 50
            |:.|:.|.       |.:..:|.|            ||||||||.|..|.:.||.||||||||.|
 Frog    19 FLLILMLFVSGVTQSKISRTKGKHWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRP 83

  Fly    51 TPTIQWYKDGVPL---KILPGSHRITLPAGGLFFLKVVNSRR-ETDAGIYWCEAKNELGVARSRN 111
            ||||:||||...:   |..|.|||:.||:|.||||::::.|: :.|.|.|.|.|:|.||.|.|||
 Frog    84 TPTIEWYKDLERVETDKDDPRSHRMLLPSGSLFFLRIIHGRKFKPDEGSYVCVARNYLGEAMSRN 148

  Fly   112 ATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRI-VDG 175
            |:|:||:|||:|||.|.:..:|.|:.|:|||..|||.||||:.|||...::|   .|..|| :.|
 Frog   149 ASLEVALLRDDFRLNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID---DKDERISIRG 210

  Fly   176 GNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVHVKPYIIRGPHDQTVLEGASVTFPCRVGG 240
            |.|.:.:.|::|.|.|.|:..|.||.|:|..|.|.|..:|..:|.|.:|.|||..:|.|.|:|.|
 Frog   211 GKLMLSNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEDEAVEFRCQVQG 275

  Fly   241 DPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLTV--- 302
            ||.|.|.|.:  ...::|..|..:.:|.:||:::.:.:|||.::|.::|.||.|.|..||||   
 Frog   276 DPQPTVRWKK--DDVDLPRGRYDIKDDYTLRIKKASSSDEGTFACISENRVGKIEASATLTVRVR 338

  Fly   303 -YAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIKNNSTLIFPGAP--PLDRFHSLNTE 364
             .|||:|:.||..:.|..|...:|.|.|.|||:|.:||..:.:..|:||..|  |..|:....|.
 Frog   339 PVAPPQFVIRPRDQIVAQGRTVTFGCEAKGNPQPAVFWQKEGSQNLLFPNQPLQPNSRYSVSPTG 403

  Fly   365 EGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSL-DSQEDRPPPIIISGPVNQTLPIKSL 428
            :    ||:|..||:|....| |.|:....||.::.||.: |...|||||||:.||.||||.:...
 Frog   404 D----LTITSIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 463

  Fly   429 ATLQCKAIGLPSPTISWYRDGIP--VQPSSKLNITTSGDLIISDLDRQQDQGLYTCVASSRAGKS 491
            |.|:||..|.|.|.|||.::|..  :...::|:|...|.|.|..| :..|.|.|||||:|.:|::
 Frog   464 AVLKCKTTGDPMPVISWLKEGFKGFIGRDARLSILDQGTLQIKGL-KVTDSGTYTCVATSSSGET 527

  Fly   492 TWSGFLRIELPTNPNI-KFYRAPEQTKCPSAPGQPKILNATASALTIVW-PTSDKAGASSFLGYS 554
            |||..|.:.......| |.|   :....|.:|.:|::.:.:.:::|:.| |.|  .|......|.
 Frog   528 TWSAVLEVTESGGAIISKNY---DLNDLPGSPSKPQVTDVSKNSVTLSWQPGS--PGILPVTSYI 587

  Fly   555 VEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGV 619
            :|.:..:.|.:|..:|:.:...::||:.|.....|:|:|||.|:.|.|.|||||:|:....:...
 Frog   588 IEAFSQSVSNSWQTVANHVKTTLYTVKGLRPNTIYLFMVRAINTEGLSDPSPISDPVRTQDISPP 652

  Fly   620 RDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTARLSWDID-SGQYIEGFYLYARELHS 683
            ..|.:.... |..|.||        :|.|........||.:::|.:| ..|:|:|:.:..|:...
 Frog   653 VQGVDHRQV-QKELGDV--------IVRLHNPVVLTPTTIQVTWMVDRQSQFIQGYRVMYRQTSG 708

  Fly   684 SEYKMV--TLLNKGQGLSSCTVPGLAKASTYEFFLVPFYKSIVGKPSNSRRMRTLEDVPEAPPYG 746
            .:....  :|..|.....|..:..|.|..|||..:.|::....|..|.|:..||.|:.|.|||..
 Frog   709 LQTPSAWQSLEVKVPAERSAVLTNLKKGITYEIKVRPYFNEFQGMDSESKSARTTEEAPSAPPQS 773

  Fly   747 MEAIQF---NRTSVFLKWLPPQPNRTRNGILTSYNVVVKGLDVHNTTRIFKNMTIDAAAPTLLLA 808
            :..:..   |.||:.:.|.|| |:..:|||:..|.:...|    |.||...|.|:|||..::::.
 Frog   774 VTVMTVGNNNSTSISISWDPP-PSDHQNGIIQDYRIWCLG----NETRFHINKTVDAAIRSVVIG 833

  Fly   809 NLTTGVTYYIAVAAATRVGVGPFSKPAVLRIDARTQSLDTGYTRYPISRDIADDFLTQTWFIVLL 873
            .|..|:.|.:.|||:|..|.|..|.|..::|..|.:.:.| .....|:..|. |.:.|..||..:
 Frog   834 GLFPGIQYRVEVAASTSAGTGVKSAPQHIQIGNRNEVVIT-ENNNSITEQIT-DVVKQPAFIAGI 896

  Fly   874 GSIIAIIVFLLG-ALVLFKRYQFIKQTSLG-----------------SLHGNHAIGTVR------ 914
            |.  |..|.|:| ::.|:.|.:  |:..|.                 ::|...|:||.:      
 Frog   897 GG--ACWVILMGFSIWLYWRRK--KRKGLSNYAVQSFTFTPADSPDTTMHHKVALGTKKGSWHKT 957

  Fly   915 ----------------------------------------------------------KFPTLPL 921
                                                                      ..||:|.
 Frog   958 VTFQRGDGGLMSNGSRPGLLNANDPSYPWLADSWPASSMPVNNSNNGPNDLVNFSCGDVLPTVPG 1022

  Fly   922 NG--------GGAVGAGGSNSTAAA----GQ----------------SGHGLWIDPTSGVWRQAA 958
            .|        .||:.:....:|.::    ||                |.|.|.:|.....|:   
 Frog  1023 QGEKTATMLSDGAIYSSIDFTTKSSYNCPGQIAQTTPYATTQILHSNSIHELAVDLPDPQWK--- 1084

  Fly   959 GGGNPGGVGSCTTKEQLPGYAQATAQQGQQPTLL---PDYERLSPLN--MPDYAEVACSTFKSPT 1018
                    .|...|..|.|.......||:....|   |||.....|:  :|.......||..|  
 Frog  1085 --------SSIQQKSDLTGLGYCLTDQGKGSNALLYIPDYRMAEGLSNRIPHNQSQDFSTTSS-- 1139

  Fly  1019 HGAPPMGGG-GGGQSASLYDSCGAYATTNVVANVKLYQNRYATKPNQSSGSNNNN---------- 1072
            |.:....|. .||:..                  |..:|:.::|.::::||:..|          
 Frog  1140 HNSSERSGSLSGGKDG------------------KRKKNKNSSKISKNNGSSWANVPLPPPPIQP 1186

  Fly  1073 -------HQGNDYQSTGMYS---APP-----SAHYGCLEPKQQQQQQQPNLMTTSTA-------- 1114
                   |.|.::|.||..:   .||     ..|.|..:..::.:::.|.......|        
 Frog  1187 LPGTEIEHYGLEHQETGYDTNGWCPPLPVQTYLHQGSDDELEEDEERVPTPPVRGVASSPAISFG 1251

  Fly  1115 --STAILTNSPAKVKKINITENKMDQLEGKSERTNPFNQQQQLLLASNALKQGLGAYANT--TLA 1175
              |||.||.||.:..: .:.:..:|:|    .|...|          :..||....::|.  .||
 Frog  1252 QQSTATLTPSPREEMQ-PMLQAHLDEL----TRAYQF----------DIAKQSWHLHSNNQPPLA 1301

  Fly  1176 AQMASGGGAGTLRRQRQPKTLYKSENNILGKSGLRQNTMNASVGAPSNGQMDFLTGGPPSEGGDF 1240
            .....|..:||.....:.....:.|:.|..:|        ..:..|       |.|...:.|...
 Frog  1302 PVPPLGYVSGTFISDLEKDIPDQEEDEIEDES--------IEITRP-------LRGLEHTPGSSM 1351

  Fly  1241 SGLGLCNSTNQLLNDWASSASIAAPGDYHFGSKQPSKQHLYVKAKDGTWSAVSSDAYQSFKHQQQ 1305
            ..|. .:.|..::|.|.|    |:..|.::.|.:.|           ..||.......|....|.
 Frog  1352 DNLD-SSVTGSMVNGWGS----ASDEDRNYSSHRSS-----------VGSATDDSIIASGNFAQS 1400

  Fly  1306 HHPFLAGSGD--------NTKSLA-SVNSLAGDSKFLSSFGSSAN 1341
                |..:.|        |:.|:| .:||.:...:..|.|.:.:|
 Frog  1401 ----LVAAADKAGFSLNGNSLSIAGKMNSFSQRPRPASPFSTDSN 1441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 22..117 CDD:299845 56/98 (57%)
I-set 23..116 CDD:254352 55/96 (57%)
I-set 122..211 CDD:254352 39/89 (44%)
Ig 125..211 CDD:299845 37/86 (43%)
I-set 215..302 CDD:254352 33/86 (38%)
Ig 232..302 CDD:299845 26/69 (38%)
I-set 306..401 CDD:254352 33/96 (34%)
Ig 320..411 CDD:299845 33/93 (35%)
I-set 412..492 CDD:254352 35/81 (43%)
IGc2 429..489 CDD:197706 25/61 (41%)
FN3 519..612 CDD:238020 30/93 (32%)
FN3 644..735 CDD:238020 22/93 (24%)
fn3 743..832 CDD:278470 31/91 (34%)
robo2XP_031752453.1 IgC_1_Robo 56..154 CDD:409490 55/97 (57%)
Ig strand B 73..77 CDD:409490 2/3 (67%)
Ig strand C 86..90 CDD:409490 2/3 (67%)
Ig strand E 113..117 CDD:409490 2/3 (67%)
Ig strand F 132..137 CDD:409490 2/4 (50%)
Ig strand G 146..149 CDD:409490 2/2 (100%)
Ig 161..246 CDD:416386 38/87 (44%)
Ig strand A 161..164 CDD:409353 2/2 (100%)
Ig strand A' 166..170 CDD:409353 0/3 (0%)
Ig strand B 174..181 CDD:409353 4/6 (67%)
Ig strand C 189..194 CDD:409353 2/4 (50%)
Ig strand C' 196..199 CDD:409353 0/2 (0%)
Ig strand D 205..209 CDD:409353 2/3 (67%)
Ig strand E 211..217 CDD:409353 2/5 (40%)
Ig strand F 224..232 CDD:409353 3/7 (43%)
Ig strand G 235..246 CDD:409353 5/10 (50%)
Ig 253..335 CDD:416386 32/83 (39%)
Ig strand A 253..256 CDD:409353 1/2 (50%)
Ig strand A' 258..262 CDD:409353 1/3 (33%)
Ig strand B 265..274 CDD:409353 3/8 (38%)
Ig strand C 280..285 CDD:409353 2/4 (50%)
Ig strand C' 288..291 CDD:409353 0/2 (0%)
Ig strand D 294..299 CDD:409353 1/4 (25%)
Ig strand E 300..307 CDD:409353 3/6 (50%)
Ig strand F 314..322 CDD:409353 2/7 (29%)
Ig strand G 325..335 CDD:409353 5/9 (56%)
IgI_4_Robo 344..441 CDD:409391 35/101 (35%)
Ig strand B 360..364 CDD:409391 1/3 (33%)
Ig strand C 373..377 CDD:409391 1/3 (33%)
Ig strand E 403..407 CDD:409391 1/7 (14%)
Ig strand F 417..422 CDD:409391 2/5 (40%)
Ig strand G 430..433 CDD:409391 0/2 (0%)
IgI_5_Robo 448..535 CDD:409544 38/87 (44%)
Ig strand B 464..468 CDD:409544 2/3 (67%)
Ig strand C 477..481 CDD:409544 2/3 (67%)
Ig strand E 501..505 CDD:409544 2/3 (67%)
Ig strand F 515..520 CDD:409544 3/4 (75%)
Ig strand G 528..531 CDD:409544 2/2 (100%)
FN3 553..646 CDD:238020 30/94 (32%)
FN3 677..762 CDD:238020 20/84 (24%)
FN3 771..863 CDD:238020 32/96 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6691
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm9461
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.000

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