DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo3 and robo4

DIOPT Version :9

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_002937566.3 Gene:robo4 / 100493397 XenbaseID:XB-GENE-955396 Length:1166 Species:Xenopus tropicalis


Alignment Length:1498 Identity:292/1498 - (19%)
Similarity:460/1498 - (30%) Gaps:586/1498 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VFIVFLLKW----------------------THAQGSH----------------------PPRIV 26
            :|::|.|.|                      |..|..|                      ||||:
 Frog     9 IFVLFPLGWCSQVSSCQCHQPVINKEHGLEATRRQTRHVQHHRSTRRHRIRGSKTRSEDFPPRII 73

  Fly    27 EHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHR----ITLPAGGLFFLKVVNS 87
            |||.|..|.:.:||||.|:|||:|.|||:||::|..::.......    :.||.|.|||..:...
 Frog    74 EHPSDLFVKKDKPATLYCRAEGNPQPTIEWYRNGEHVETSTDDKTQRSYVQLPEGPLFFFSLNQR 138

  Fly    88 RRETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPT 152
            :.::|.|||.|.|:|.||.|.||||:|.||.|||:|||.|.:..:|.|....:||..|:|.|||.
 Frog   139 KGKSDEGIYTCVARNHLGTAFSRNASLYVAALRDDFRLNPSDAVVAVGKQLEIECLPPKGHPEPN 203

  Fly   153 VTWKKGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVHVKPYI 217
            |||||.|..::...|:..  :..|.|.|..|.:||.|.|.|:|.|.||.|||..|.:.|..||..
 Frog   204 VTWKKDGIPINHNNSRYT--ISAGKLFIGKALKTDSGLYSCLASNQVGERESRAAKIVVLEKPMF 266

  Fly   218 IRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIADEGE 282
            ...|.|.|...|::|.|.|...|||.|...|  :...|::|..|..:..:.:||:..||:.|.|:
 Frog   267 TYKPSDVTAKFGSTVQFGCGAQGDPKPTFHW--SKENGDLPQGRYEITNENTLRIRSVTLYDSGK 329

  Fly   283 YSCEADNVVGAITAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIKNNSTL 347
            |.|.|.|.:..::|...|||                                             
 Frog   330 YICTAGNQLETVSAKALLTV--------------------------------------------- 349

  Fly   348 IFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSLDSQEDRPPP 412
                ..|||                                                        
 Frog   350 ----QDPLD-------------------------------------------------------- 354

  Fly   413 IIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSSKLNITTSGDLIISDLDRQQDQ 477
               :|.:.:                                                  :||   
 Frog   355 ---TGQIEK--------------------------------------------------ERQ--- 363

  Fly   478 GLYTCVASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASALTIVWPTS 542
                                           .||                               
 Frog   364 -------------------------------IYR------------------------------- 366

  Fly   543 DKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSLGFSPPSPI 607
                                                                             
 Frog   367 ----------------------------------------------------------------- 366

  Fly   608 SEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTARLSWDI-DSGQYI 671
                   :|:|||                         |.|....|..|.:..:.|.: ....:.
 Frog   367 -------ELMGVR-------------------------VHLDNITALPSASVYVHWQVLTESPFT 399

  Fly   672 EGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYEFFLVPFYKSIVGKPSNSRRMRTL 736
            ||:.::.|.|.|:|.:............|..:|.|.:...|||.:.||.....|..||.:.:|..
 Frog   400 EGYSVFYRTLSSTESEWTEWTKSRINEYSTVIPSLWRGQKYEFKIRPFAGKNYGPDSNIKHLRIP 464

  Fly   737 EDVPEAPPYGME--AIQFNRTSVFLKWLPPQPNRTRNGILTSYNVVVKGLDV---HNTTRIFKNM 796
            |:||...|..:.  |::....::.:.|.||..|      :.|.|  :||..|   .|.|....:.
 Frog   465 EEVPNIAPQNINVTAVEGGNGTIVVSWEPPPKN------IHSSN--IKGYKVWCFENETHPKADW 521

  Fly   797 TIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKPAVLRIDARTQSLDTGYTRYPISRDIAD 861
            .:|....:|.:..|.:|:.|.:.|||....|:|..|.|..:.||:            |..:::.|
 Frog   522 IVDEETKSLEIPMLASGIKYQVQVAAINDAGIGMPSIPKYIMIDS------------PEVKEVKD 574

  Fly   862 DFLTQTWFIVLL---------GSI--IAIIVFLLGALVLFKRYQFIKQTSLGSLHGNHAIGTVRK 915
            :   ..:|.::|         |::  :|.|:.::.|:.:.:|:.....|...|:.||    ::.:
 Frog   575 E---NIYFELILQVVRHPAFIGTVGTVAWILLMVAAVYVCQRHSKRYSTKQHSILGN----SLYR 632

  Fly   916 FPTLPLNGGGAVGAGGSNSTAAAGQSGHGL------WIDPTSGVWRQAAGGGNPGGVGSCTT--- 971
            |              .|..|...    |.:      |:..|   |:.|:...|.....|..:   
 Frog   633 F--------------ASEDTIIK----HRMDISDSPWLSHT---WKSASCSRNYSSTISMNSQLL 676

  Fly   972 -----------KEQLPGYAQATAQQGQQPTLLPDYERLSPLNMPDYAEVACSTFKSPTHGAPPMG 1025
                       |..:....::...:.|...|:||...|......|......:||:.    .|...
 Frog   677 WSETKDTADFHKSTMSFERKSEGSRSQIIPLVPDSNSLYGTMYVDLPGKDMTTFQR----LPSDK 737

  Fly  1026 GGGGGQSASLYDSCGAYATTNVVANVKLYQNRYATKPNQSSGSNN---------------NNHQG 1075
            ..|.|:.....|..|.           |:.....:..|..||||:               ||:..
 Frog   738 SQGMGRHFKTPDPLGL-----------LHHRPLPSYLNDFSGSNDMNGGTRSKLPWQPNINNNPD 791

  Fly  1076 NDYQST----------GMYSAPPSAHYGCLEPKQ-----------------------QQQQQQPN 1107
            ..::.:          ...|||.|.:  |..|||                       .:....|.
 Frog   792 ISFKDSWSKNCKKELQHANSAPLSPY--CQAPKQGDSVPSIQHLNIKKVGKGDYAKVMKTFSSPK 854

  Fly  1108 LMTTSTA--------STAILTNSPAKVKKINITENKMDQLEGKSERTNPFNQQQQLLLASNALKQ 1164
            ::..:|:        .|..|...|......|...|..|::.|.|..:.....|::.....|:.|:
 Frog   855 ILHYTTSLQVMDLLPYTPSLPPPPVPPPDENPIHNDKDKISGCSVSSYSVRNQEKQGHKINSKKK 919

  Fly  1165 GLGAYANTTLAAQM--ASGGGAGTLRRQRQPKTLYKSENNILGKSGLRQNTMNASVGAPSNGQM- 1226
            ......|...|::.  .:..|...|..:...:.|..|:.   |::...::..:||:..|.:... 
 Frog   920 SPPDTLNIKPASECFPINDDGDNVLTPEDVAQYLELSDQ---GQNTRHKSEYDASLPRPFSPSQT 981

  Fly  1227 -DFLTGGPPSEGG--------DFSGLG-------LCNSTNQLLNDWASSASIAAPGDYHFGSKQP 1275
             .::....|||..        |...:|       .|.:....::::.||.:    |....|    
 Frog   982 YGYICSPIPSEADVVDEDDDLDLEDIGSLKSYRKYCETPTSSISEYESSMA----GSLVNG---- 1038

  Fly  1276 SKQHLYVKAKDGTWSAVSSDAYQSFKHQQQHHPFLAGSGDNT----KSLASVNSLAGDSKFLSSF 1336
                         |.:||.|.|.|.:..      :..|.|.:    .:.|...::|.||   ..|
 Frog  1039 -------------WGSVSEDNYTSARCS------MVSSSDGSFLMDANFAKALAVAVDS---FCF 1081

  Fly  1337 GSS 1339
            |.|
 Frog  1082 GGS 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 22..117 CDD:299845 45/98 (46%)
I-set 23..116 CDD:254352 44/96 (46%)
I-set 122..211 CDD:254352 37/88 (42%)
Ig 125..211 CDD:299845 35/85 (41%)
I-set 215..302 CDD:254352 28/86 (33%)
Ig 232..302 CDD:299845 23/69 (33%)
I-set 306..401 CDD:254352 3/94 (3%)
Ig 320..411 CDD:299845 3/90 (3%)
I-set 412..492 CDD:254352 3/79 (4%)
IGc2 429..489 CDD:197706 2/59 (3%)
FN3 519..612 CDD:238020 0/92 (0%)
FN3 644..735 CDD:238020 22/91 (24%)
fn3 743..832 CDD:278470 23/93 (25%)
robo4XP_002937566.3 Ig 70..168 CDD:416386 44/97 (45%)
Ig strand A 70..74 CDD:409353 3/3 (100%)
Ig strand A' 77..82 CDD:409353 1/4 (25%)
Ig strand B 86..94 CDD:409353 5/7 (71%)
Ig strand C 100..105 CDD:409353 3/4 (75%)
Ig strand C' 108..110 CDD:409353 0/1 (0%)
Ig strand D 121..125 CDD:409353 0/3 (0%)
Ig strand E 128..134 CDD:409353 4/5 (80%)
Ig strand F 145..153 CDD:409353 5/7 (71%)
Ig strand G 156..168 CDD:409353 7/11 (64%)
Ig 175..260 CDD:416386 36/86 (42%)
Ig strand A 175..178 CDD:409353 2/2 (100%)
Ig strand A' 180..184 CDD:409353 0/3 (0%)
Ig strand B 188..195 CDD:409353 2/6 (33%)
Ig strand C 203..208 CDD:409353 3/4 (75%)
Ig strand C' 210..213 CDD:409353 1/2 (50%)
Ig strand D 219..222 CDD:409353 0/4 (0%)
Ig strand E 225..231 CDD:409353 3/5 (60%)
Ig strand F 238..246 CDD:409353 4/7 (57%)
Ig strand G 249..260 CDD:409353 5/10 (50%)
Ig 269..349 CDD:416386 27/81 (33%)
Ig strand A' 272..276 CDD:409353 2/3 (67%)
Ig strand B 279..288 CDD:409353 3/8 (38%)
Ig strand C 294..299 CDD:409353 1/6 (17%)
Ig strand C' 302..305 CDD:409353 1/2 (50%)
Ig strand D 308..313 CDD:409353 1/4 (25%)
Ig strand E 314..321 CDD:409353 2/6 (33%)
Ig strand F 328..336 CDD:409353 4/7 (57%)
Ig strand G 339..349 CDD:409353 2/9 (22%)
FN3 377..462 CDD:238020 20/84 (24%)
fn3 471..557 CDD:394996 23/93 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I8278
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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