Protein Alignment CG5397 and CES2

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_003860.3
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 153/548 - (27%)
• Similarity: 236/548 - (43%)
• Gaps: 99/548 - (18%)

  Fly    67 RNPSTGIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQP------------HPQ 118
            :..:.|:.:|||:.:|:||:||||::.| ..:..:|..:.|.|...|:|.            :..
Human    49 KGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMT 113

  Fly   119 FPQRIIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMAQ-RGAIVVAPQY 182
            ||...: .||||.|::|||....|.:.|||.||||.|...:|.|:.||.:.:|. ...:||..||
Human   114 FPSDSM-SEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQY 177

  Fly   183 RLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPT 247
            |||.||....|.|...||....|..||||||...|::|||||.:|...|..:|..|...|.:||.
Human   178 RLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPI 242

  Fly   248 SRSAGDVHGVVAMSGTAL--SQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKN 310
            |:  |..||.:..||.||  ...|...:.:.:|  ||.::.|...:...:|.|||.||.|:|
Human   243 SQ--GLFHGAIMESGVALLPGLIASSADVISTV--VANLSACDQVDSEALVGCLRGKSKEEI--- 300

  Fly   311 DDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTK 375
                    ||.....|.:.|.|          ||..||.    .|::.|.|::|..:|.:.||..
Human   301 --------LAINKPFKMIPGVV----------DGVFLPR----HPQELLASADFQPVPSIVGVNN 343

  Fly   376 HETANSVTVETIEKVFGSAEQFLGSLSD-SLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQD 439
            :|.  ...:..:.:::.:.::.....|. :|.|:.:.|.:....|.:.:.|..|...
Human   344 NEF--GWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNG-------- 398

  Fly   440 VWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLP 504
               .||.|.     ::..|...|.:|.:||:.........||.:.|.|::..:..|.|
Human   399 ---DPQTLQ-----AQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNI------- 448

  Fly   505 IVSETAHDKPETVGHGDEIGYMFDANDIF-GNPMEETRLTSAEDLKVRNNLIDLLVKFANK---- 564
               ...|.|.:   ||||:.::|  ...| ||.::.|.    |:.::...::.....||..
Human   449 ---RPPHMKAD---HGDELPFVF--RSFFGGNYIKFTE----EEEQLSRKMMKYWANFARNGNPN 501

  Fly   565 ----------DKEEGGKSSIFQSVTGKA 582
                      |:||.......|...|:|
Human   502 GEGLPHWPLFDQEEQYLQLNLQPAVGRA 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	153/548 (28%)
CES2	NP_003860.3	COesterase	30..538	CDD:395084	153/548 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559