DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and Ces2f

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	593	Identity:	162/593 - (27%)
Similarity:	242/593 - (40%)	Gaps:	137/593 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVI------FARLFDRDARVEGFRN 68
            ||:|||              ||:     |...|:|.|:.:...      |..|.|..|
Mouse    17 LLVLLL--------------HVK-----GLDSSEASPIRNTHTGQVRGKFVHLTDIKA------- 55

  Fly    69 PSTGIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPH---------------P 117
               |.::|||:.:|:|||||||::.| ..:..:|..:.|.....|:|..               |
Mouse    56 ---GAHNFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAMCLQNDDIVNLEGLKIIKMILP 117

  Fly   118 QFPQRIIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPM-AQRGAIVVAPQ 181
            .|..    .||||.||:|||....|.:.|||.||:|.||...|.|:.||.:.: |....:||..|
Mouse   118 PFSM----SEDCLYLNIYTPAHAQEGSNLPVMVWLHGGGLVAGMASMYDGSVLAATEDVVVVVTQ 178

  Fly   182 YRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSP 246
            ||||..|....|.:|..||....|..|||.||...|:.|||||..|...|..:|..|..:..:||
Mouse   179 YRLGIPGFYSTGDEQARGNWGFLDQTAALHWVQQNIANFGGNPDSVTLFGQSAGGTSVSFHVLSP 243

  Fly   247 TSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKND 311
            .|:  |..|..:..||.||....:...|.....:||.::||.|.|...:|.|||.||..:|:
Mouse   244 VSQ--GLFHRAIMESGVALLPTIIPDSPEMIFTKVANLSGCETSNSEALVRCLRGKSEAEIL--- 303

  Fly   312 DKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKH 376
                       |:.|...    |.|.:.   ||:.||.    .|::.|.|::|..:|.:.||...
Mouse   304 -----------AMSKAFR----FMPAVV---DGKFLPR----HPKKLLASADFHPVPSIIGVNND 346

  Fly   377 ETANSVT-----VETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPG---LTSVL 433
            |....:.     .:||.|:             :.|.|.:.:||  .|.|:..|...|   :...|
Mouse   347 EYGWIIPKIFKFSQTIRKI-------------NRNNLKAIMKI--TTEQMMLPSECGDLLIEEYL 396

  Fly   434 TPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEYNGTKSKGIN 498
            ..| :|.|.:.....         |...|.|..:||:...:.....||.:.|.|::   :|..:.
Mouse   397 RDT-EDPWTLQMQFR---------EMIGDFLIIIPALQVARFQRSHAPVYFYEFQH---RSSLLK 448

  Fly   499 FLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPME---ETRLTSAEDLKVRNNLIDLLVK 560
            :.:...:.::          ||||: |:...:..:|....   |.:|.|.:.:|...|    ..:
Mouse   449 YFRPWHVKAD----------HGDEL-YLIFGSFFWGLKFSFTAEEKLLSRKMMKYWAN----FAR 498

  Fly   561 FANKDKEE 568
            :.|.:.|:
Mouse   499 YGNPNSED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	147/535 (27%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	71/195 (36%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	153/559 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910