DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5397 and NLGN2

DIOPT Version :9

Sequence 1:NP_001259865.1 Gene:CG5397 / 33313 FlyBaseID:FBgn0031327 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_065846.1 Gene:NLGN2 / 57555 HGNCID:14290 Length:835 Species:Homo sapiens


Alignment Length:678 Identity:174/678 - (25%)
Similarity:266/678 - (39%) Gaps:198/678 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAP---------------PVDDPVIFARLFDRDA 61
            ||.|.:|.||..:.||          ||....||               ||.:...        .
Human     3 LLALCLVGLAGAQRGG----------GGPGGGAPGGPGLGLGSLGEERFPVVNTAY--------G 49

  Fly    62 RVEGFR----NPSTG-IYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPHPQFP 120
            ||.|.|    |...| :..|||:.||.||:|..|:..| ......|..|||...|.|       |
Human    50 RVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPAC-------P 107

  Fly   121 QRIIG-------------------------DEDCLLLNVYTP-------QMPDETT--------- 144
            |.:.|                         .||||.||:|.|       :..||.|         
Human   108 QNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIR 172

  Fly   145 ---GLPVFVWIHPGGYRYGSAAQYDATPMAQRGAIVVAP-QYRLGSLGIMGDGTKQFDGNLAMFD 205
               ..||.:::|.|.|..|:...:|.:.:|..|.::||. .||||.||.:..|.:...||..:.|
Human   173 DPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLD 237

  Fly   206 LAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAM 270
            ...||||:::.|::|||:|:::...|.|:||:....|.:|  ..|.|.....:|.||||:|.:::
Human   238 QIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILS--HHSEGLFQKAIAQSGTAISSWSV 300

  Fly   271 DKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQ 335
            :.:|::..:.:|...||...:..|.|.|||.|.:.:::  |..||..|.           ::.|.
Human   301 NYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELV--DQDVQPARY-----------HIAFG 352

  Fly   336 PHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSV--TVETIEKVFGSAEQFL 398
            |.:    ||..:|.    :||..::...|....:|.||.:.|....|  :.|:.:.|..||..| 
Human   353 PVV----DGDVVPD----DPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDF- 408

  Fly   399 GSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDV---WKVPQALNVDQVLSKVVEST 460
                    .:::|  :|.|.|      .|....||..|::.:   |       .|:...::...|
Human   409 --------TVSNF--VDNLYG------YPEGKDVLRETIKFMYTDW-------ADRDNGEMRRKT 450

  Fly   461 TDVLFN-----LPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPE--TV 517
            ...||.     .|||.|.::.:.. :|.:.|:| |:..:::|                :||  ..
Human   451 LLALFTDHQWVAPAVATAKLHADYQSPVYFYTF-YHHCQAEG----------------RPEWADA 498

  Fly   518 GHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDLLVKF-ANKDKEEGGKSSIFQSV--- 578
            .||||:.|      :||.||     ..|.||            | .|..|.:...|::..:.   
Human   499 AHGDELPY------VFGVPM-----VGATDL------------FPCNFSKNDVMLSAVVMTYWTN 540

  Fly   579 ---TGKATPFIKIDTKLQTSNDFRFCEL 603
               ||.....:..|||...:...||.|:
Human   541 FAKTGDPNQPVPQDTKFIHTKPNRFEEV 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5397NP_001259865.1 COesterase 62..600 CDD:278561 157/608 (26%)
Aes 82..>261 CDD:223730 65/224 (29%)
NLGN2NP_065846.1 COesterase 41..601 CDD:278561 162/630 (26%)
Aes <170..>268 CDD:223730 32/97 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..668
Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9 678..698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..835
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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