Protein Alignment CG5397 and NLGN4X

DIOPT Version :9

• Sequence 1: NP_001259865.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 151/610 - (24%)
• Similarity: 246/610 - (40%)
• Gaps: 152/610 - (24%)

  Fly    62 RVEGFRNPSTG-----IYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQP----- 115
            ::.|.|.|...     :..:||:.||.||.|..|:..| ......|..|.|:....|.|.
Human    54 KIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERS 118

  Fly   116 --HPQFP----------QRIIGD--EDCLLLNVYTP-----------------------QMPDET 143
              |...|          ...:.|  ||||.||:|.|                       .:.|:.
Human   119 LLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQN 183

  Fly   144 TGLPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLA 207
            :..||.|:||.|.|..|:....|.:.:|..| .||:...||||.||.:..|.:...||..:.|..
Human   184 SKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQI 248

  Fly   208 AALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDK 272
            .||||:.:.:..|||:||:|...|.|:||:....|::|  ..|.|.....:..||||||.:|::.
Human   249 QALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS--HYSEGLFQKAIIQSGTALSSWAVNY 311

  Fly   273 EPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPH 337
            :|.:..:.:|...||...:..::|.|||:|:.:::|:     ||        :...|.::.|.|.
Human   312 QPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQ-----QT--------ITPATYHIAFGPV 363

  Fly   338 IESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLS 402
            |    ||..:|.    :|:..::...|....::.||.:                |...:|:..:.
Human   364 I----DGDVIPD----DPQILMEQGEFLNYDIMLGVNQ----------------GEGLKFVDGIV 404

  Fly   403 DSLNKLT---------SFLKIDKLTGQIAKPELPGLTSVLTPTLQDV---WKVPQALNVDQVLSK 455
            |:.:.:|         :|  :|.|.|      .|.....|..|::.:   |...:  |.:.....
Human   405 DNEDGVTPNDFDFSVSNF--VDNLYG------YPEGKDTLRETIKFMYTDWADKE--NPETRRKT 459

  Fly   456 VVESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGH 519
            :|...||..:..|||.|..:.::. :|.:.|:| |:..:|:    :|  |..:::|        |
Human   460 LVALFTDHQWVAPAVATADLHAQYGSPTYFYAF-YHHCQSE----MK--PSWADSA--------H 509

  Fly   520 GDEIGYMFDANDIFGNPM-EETRLTSA----EDLKVRNNLIDLLVKFANKDKEEGGKSSIFQSVT 579
            |||:.|      :||.|| ..|.|.|.    .|:.:...::.....||.               |
Human   510 GDEVPY------VFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAK---------------T 553

  Fly   580 GKATPFIKIDTKLQTSNDFRFCELS 604
            |.....:..|||...:...||.|::
Human   554 GDPNQPVPQDTKFIHTKPNRFEEVA 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	148/604 (25%)
		Aes	82..>261	CDD:223730	64/222 (29%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	151/610 (25%)
		Aes	<179..>286	CDD:223730	39/106 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810