DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and ces2b

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	574	Identity:	161/574 - (28%)
Similarity:	239/574 - (41%)	Gaps:	157/574 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DDPVIFARLFDRDARVEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPP 111
            :.||:..:|..........:...:.|.|:..:.:|:.||||||.:.| ......|..:|||..|.
Zfish   553 EGPVVNTKLGSLRGSYMMAKGKDSVISSYFAIPFAKSPVGPLRLTPPQPADAWQGVRDATKQPPM 617

  Fly   112 CIQP-------------HPQFPQRIIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAA 163
            |:||             ..:||:   ..||||.||:|||..|.:...|||.||||.||..:|||:
Zfish   618 CLQPKEVMVDLLATMPLKTEFPE---VSEDCLYLNIYTPSKPGDNKKLPVMVWIHGGGLAFGSAS 679

  Fly   164 QYDATPM-AQRGAIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQV 227
            .:||..: |.:..:||..|||||.||....|.:...||..:.|..|||:||.:.|..|||:|..|
Zfish   680 IFDAHALAAYQDIVVVMVQYRLGLLGFFSTGDEHAPGNYGLLDQVAALQWVQENIHSFGGDPGSV 744

  Fly   228 QAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNE 292
            ...|..:|..||..|.:||.  ||...|..:|.||||.....|..:|:.:.:.:..::||...:.
Zfish   745 TVFGESAGGVSASLLVLSPL--SANLFHRAIAESGTAAMNAIMSPDPLSTARSLGNVSGCDISST 807

  Fly   293 LEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQ 357
            .:||:|:...:.|||:    |:..|::..|.   |:|            .||:.||..:    ::
Zfish   808 KKIVDCVMQMTEEDIL----KIAREQVLLRF---GVT------------VDGQFLPKSV----DE 849

  Fly   358 QLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIA 422
            .|:|..||.:||:||||..:                                         |...
Zfish   850 LLQSQEFSKVPLMTGVTDDD-----------------------------------------GGFT 873

  Fly   423 KPEL---PGLTSVLT--------PT----LQDVWKVPQALNVDQVLSKVVESTTDVL-------- 464
            .||.   ||....:|        ||    |||    |....:  ||.:.:.:|||.:
Zfish   874 LPEFIAPPGWRDGMTKDQIMPFLPTYNYDLQD----PGLAEI--VLKEYLGATTDKIKIRDGFRE 932

  Fly   465 ------FNLPA-VLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVG--HG 520
                  ||||| .|........||.:||.|::.....:               :.:|..||  ||
Zfish   933 IVGDFFFNLPARKLANYHRDTGAPVYMYEFQHPAYIFQ---------------NKRPSFVGCDHG 982

  Fly   521 DEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDLLVKFANKDKEEGGKSSI 574
            ||:.::|  ...|||          ..:||...|        :|:::|..|:::
Zfish   983 DELLFVF--GYCFGN----------GHIKVEGEL--------SKEEQELCKTTM 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	158/560 (28%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	78/193 (40%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613
		COesterase	553..1065	CDD:306613	161/574 (28%)
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910