DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and ces3

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001038401.1	Gene:	ces3 / 560651	ZFINID:	ZDB-GENE-030131-9563	Length:	549	Species:	Danio rerio

Alignment Length:	552	Identity:	153/552 - (27%)
Similarity:	229/552 - (41%)	Gaps:	116/552 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 APPVDD--PVIFARLFD-RDARVEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFN 104
            ||..:|  ||:..:... |...|:...:|:. :..:||:.:|:|||||.|.:.| ..:...|..|
Zfish    19 APVKEDSGPVVVLKHGSVRGQYVKAKGSPAV-VEQYLGIPFAQPPVGPHRLAAPQPVQGWEGIRN 82

  Fly   105 ATKHGPPCIQ-PH--PQFPQRIIGD-------EDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRY 159
            ||::...|:| |:  |::.:.:..:       ||||.||||||....|:...||.||||.|....
Zfish    83 ATEYSSMCLQDPNIVPKYAKSMTLELPPTGVSEDCLYLNVYTPSQRSESDKFPVMVWIHGGALVI 147

  Fly   160 GSAAQYDATPM-AQRGAIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGN 223
            |.|..||.||: |....:||..|||||.||.:..|.:...||....|..|||:||...|..|||:
Zfish   148 GGACMYDGTPLAAYEKVVVVVIQYRLGILGYLSTGDQHAQGNWGFLDQIAALQWVQQNIEAFGGD 212

  Fly   224 PKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCP 288
            |:.|...|..:|..||..|::||.::  |.....:..||.|..:....|:|:...:.:|.|..|.
Zfish   213 PQSVTIAGESAGGISASLLTLSPMTK--GLFQRAIFQSGVATVKGYSFKDPLTYAKVIANITECD 275

  Fly   289 TGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVG 353
            ..:...:|.|:|..:.|.|||...|  ..||.|..:                  ||    ..|..
Zfish   276 FSSSEVLVKCIREMTEEQIIKAAQK--KYRLPGATV------------------DG----EFIKA 316

  Fly   354 EPEQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFG------SAEQFL------------GS 400
            :||:.|||.:|..||:|.|.|.||...:::...:.|.:.      ||:|.|            |.
Zfish   317 QPEEILKSKDFPKIPILVGTTNHEFGWTLSHAILPKDWAKGMDAKSAKQTLDFFYNAGASEANGI 381

  Fly   401 LSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLF 465
            ::|...|                       :..||              :::.....|...|::.
Zfish   382 IADEYFK-----------------------NAKTP--------------EEIRDAFTELLGDIIM 409

  Fly   466 NLPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDA 529
            .:|::......... ||.:||.|::.             |.::...........||||||:||.|
Zfish   410 VIPSIKVASYHRDAGAPVYMYEFQHG-------------PSIANKFRPSFVKADHGDEIGFMFGA 461

  Fly   530 NDIFGNPMEETRLTSAEDLKVRNNLIDLLVKF 561
            ....|.......||..|     |.|...::|:
Zfish   462 CFWDGQVKVTGTLTEEE-----NQLCRTVMKY 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	147/531 (28%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	73/190 (38%)
ces3	NP_001038401.1	COesterase	24..535	CDD:278561	151/547 (28%)
ces3	NP_001038401.1	Aes	<122..>235	CDD:223730	48/112 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010