Protein Alignment CG5397 and NLGN3

DIOPT Version :9

• Sequence 1: NP_001259865.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 160/607 - (26%)
• Similarity: 247/607 - (40%)
• Gaps: 174/607 - (28%)

  Fly    10 LLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPST--- 71
            |.|..||:.:.||                 .|:.||.|:  ..|.:|  |.|||.   .||.
Human    24 LTLWFLSLALRAS-----------------TQAPAPTVN--THFGKL--RGARVP---LPSEILG 64

  Fly    72 GIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQP-HPQFPQRII---------- 124
            .:..:||:.||.||:|..|:..| .....:|..|||...|.|.|. |...|:.::
Human    65 PVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDI 129

  Fly   125 -------GDEDCLLLNVYTP------------QMP------------------------DETTGL 146
                   .:||||.||||.|            :.|                        ||...:
Human   130 VATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDI 194

  Fly   147 ------PVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSLGIMGDGTKQFDGNLAMF 204
                  ||.|:||.|.|..|:....|.:.:|..| .||:...||:|.||.:..|.:...||..:.
Human   195 RDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLL 259

  Fly   205 DLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYA 269
            |...|||||::.|::|||:|:::...|.|.||:....|::|  ..|.|.....:..||:|||.:|
Human   260 DQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLS--HHSEGLFQRAIIQSGSALSSWA 322

  Fly   270 MDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGF 334
            ::.:||:....:|...||...:.:::|:|||.|||:::::.|  :|..|.           :|.|
Human   323 VNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQD--IQPARY-----------HVAF 374

  Fly   335 QPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSV--TVETIEKVFG----- 392
            .|.|    ||..:|.    :||..::...|....::.||.:.|....|  .|:..:.|.|
Human   375 GPVI----DGDVIPD----DPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDY 431

  Fly   393 SAEQFLGSL------SDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQ 451
            |...|:.:|      .|:|.:...|:..|                         |  ....|.:.
Human   432 SVSNFVDNLYGYPEGKDTLRETIKFMYTD-------------------------W--ADRDNPET 469

  Fly   452 VLSKVVESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPE 515
            ....:|...||..:..|:|:|..:.:|. :|.:.|:| |:..:|    .:|  |..|:.|
Human   470 RRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAF-YHHCQS----LMK--PAWSDAA----- 522

  Fly   516 TVGHGDEIGYMFDANDIFGNPM 537
               ||||:.|      :||.||
Human   523 ---HGDEVPY------VFGVPM 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	146/555 (26%)
		Aes	82..>261	CDD:223730	67/240 (28%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	155/595 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		2/24 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810