DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and alpha-Est4

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	128/538 - (23%)
Similarity:	225/538 - (41%)	Gaps:	104/538 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VIFARLFDRDARVEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQ 114
            ::...|:|..            .|:|.|:.||.||:|.||:..| ..|...|..:.:|....|:|
  Fly    22 ILLKSLYDEQ------------FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ 74

  Fly   115 PHPQFPQRIIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATP--MAQRGAIV 177
            . ....:.:.|.||||.||:....:..:.  :||.|:||.|.::.|.:::....|  ..:...:.
  Fly    75 V-STLTKEVEGSEDCLYLNISVKTLNGDP--MPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVY 136

  Fly   178 VAPQYRLGSLGI--MGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAM 240
            ::..:|||.||.  :.|...:..||..:.|:..||||:....:.|.|:|:::...||.||:.:..
  Fly   137 ISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQ 201

  Fly   241 YLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGN-ELEIVNCLRSKSA 304
            .|..||  :|.|..|..:.::|.::.   :::.| |....:||..|....| :.:::..|.....
  Fly   202 LLLASP--QSEGLFHRAILLAGFSME---LNRLP-QMEYRLAKHLGYEGDNVDSQVLEFLLKADP 260

  Fly   305 EDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPL 369
            ..|:..|.....|:..|.        |:.|:|.|||.....|   :::.||....:::..:.||:
  Fly   261 ALIVSADFFTPLEKRQGH--------NMPFKPSIESYSTPNA---VLLAEPIDLQRTTWSNRIPI 314

  Fly   370 LTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDK--LTGQIAKPELPGLTSV 432
            :.|....|..:                           :.||:|::.  |......||     .|
  Fly   315 ILGANSGEGMS---------------------------IFSFVKMNPSWLKEFQCNPE-----RV 347

  Fly   433 LTPTLQDVWKVPQALNVDQVL------SKVVESTTDVLFNLPAVLT--------TQVWSRL---- 479
            |..||::.....|...:.|.|      :...|.|.|....|..:.|        ..:.|||
  Fly   348 LPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQ 412

  Fly   480 APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETRLTS 544
            ||.::|.|:::   |...||.: :..:.:    :...|||.||:||:|.....|  .::::|
  Fly   413 APTYLYRFDFD---SPDFNFYR-IRFMGK----EQRGVGHVDELGYIFKLPATF--KLDKSR--- 464

  Fly   545 AEDLKVRNNLIDLLVKFA 562
            .|...:| .|:.:.|:||
  Fly   465 PEFTAIR-RLVAMFVQFA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	126/527 (24%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	53/183 (29%)
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	128/538 (24%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	34/116 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	5	4.810