DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and alpha-Est5

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	122/492 - (24%)
Similarity:	206/492 - (41%)	Gaps:	106/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 YSFLGMHYAEPPVGPLRYSRPV-YKRLAGDFNATKHGPPCIQPHPQFPQRIIGDEDCLLLNVYTP 137
            :||..:.:|:||:|.||:..|| ....:|..:.|.:.....| .....:.|.|.||||.||||:.
  Fly    34 FSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQ-RGLLTREIEGGEDCLYLNVYSK 97

  Fly   138 QMPDETTGLPVFVWIHPGGYRYGSAAQ--YDATPMAQRGAIVVAPQYRLGSLGIMG--DGTKQFD 198
            |:..|.. |||.|:|:.|.:..|.|.:  |.......:..::|...||:..||.:.  |.:.:..
  Fly    98 QLKSEKP-LPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVP 161

  Fly   199 GNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGT 263
            ||..:.|...||:||..|||.|.|:...:...|..:|..|..:  |..|.::.|..|..:.||||
  Fly   162 GNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHF--MMCTEQTRGLFHKAIPMSGT 224

  Fly   264 ALSQYAMDKEPVQSVQ-EVAKINGCPTG--NELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALV 325
            ..:.:|  ..|.:... .:|:.||. ||  ::.:::..|:...|.|::.::......|..|...
  Fly   225 VHNYWA--NNPAEDFAFRLAQQNGF-TGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLF- 285

  Fly   326 KGLTGNVGFQPHIES---EDDGRALPSLIVGEPEQQLK----SSNFSGIPLLTGVTKHE-----T 378
                   .|.|.:|:   ||       .:|.:|..::.    |:||   |::.|.|..|     .
  Fly   286 -------AFGPTVEAYVGED-------CVVPKPPVEMARDAWSNNF---PVMLGGTSFEGLFMYP 333

  Fly   379 ANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKV 443
            |.|..::.::           |||....:|   :.:|..|....|
  Fly   334 AVSANLKALD-----------SLSQDPTRL---VPVDVRTVSSEK-------------------- 364

  Fly   444 PQALNVDQVLSKVV----ESTTDVLFNLPAVLTTQV-W--------SRL----APAFMYSFEYNG 491
             :.|...|.|.|..    ..::::|.|:....:.:: |        :||    ||.:.|.|:::
  Fly   365 -ENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFD- 427

  Fly   492 TKSKGINFLKGLPIVSETAHDKPET-VGHGDEIGYMF 527
              |...||.:     ::...||.:| |.|.|::.|:|
  Fly   428 --SPNFNFYR-----AKFCGDKIKTGVAHADDLSYLF 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	122/492 (25%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	57/183 (31%)
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	122/492 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	4	3.810