DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	139/574 - (24%)
Similarity:	227/574 - (39%)	Gaps:	145/574 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VEGFRNPS---TGIYSFLGMHYAEPPVGPLRYSRP----VYKRLAGDFNATKHGPPCIQPHPQFP 120
            ::|.:..|   ...:||..:.:|:||||.|||..|    |:..:.   :.|..||..:|.|..|
  Fly    41 IKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVR---SCTSQGPKPLQKHFVF- 101

  Fly   121 QRIIGDEDCLLLNVYTPQM-PDETTGLPVFVWIHPGGYRYGSAAQ--YDATPMAQRGAIVVAPQY 182
            :...|.||||.|||||..: |  |..:||.|||:.||:::|.|::  |....:.:...:|::..|
  Fly   102 EMTDGSEDCLYLNVYTKNLYP--TKPMPVMVWIYGGGFQFGEASRECYSPDYLLREDVVVISINY 164

  Fly   183 RLGSLGIMGDGTKQ--------------------FDGNLAMFDLAAALRWVTDYISYFGGNPKQV 227
            |||.||...|..|:                    ..||..:.|...|||||....|.|||:...:
  Fly   165 RLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANI 229

  Fly   228 QAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNE 292
            ...|..:|:||..|:.:  |.::.|..|..:.|||..||.:|:..:.....:...:.......|.
  Fly   230 TIFGDSAGSASVHYMMI--TEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAVQAGYAGENNT 292

  Fly   293 LEIVNCLRSKSAEDIIKND-----DKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIV 352
            .::...|::....:|||.:     |:.:.||:       |.:.....:|::.|.       .::.
  Fly   293 RDVWEFLKNAKGSEIIKANGELCIDEEKKERI-------GFSFGPVIEPYVTSH-------CVVP 343

  Fly   353 GEPEQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKL 417
            .:|.:.::::..:.|||:.|...:|                     |.|..|..|
  Fly   344 KKPIEMMRTAWSNNIPLIIGGVSNE---------------------GLLLYSETK---------- 377

  Fly   418 TGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQ-------------------------VLSKVV 457
            |......||.....|          ||..||:|:                         .|.:.:
  Fly   378 TNPKCLNELDDCRFV----------VPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYL 432

  Fly   458 ESTTDVLFNLP---AVLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGH 519
            :..:...|..|   .||:...::|.||.::|.|:::   ||..|.|:.|     :...|.....|
  Fly   433 QMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFD---SKHFNHLRIL-----SCGKKVRGTCH 489

  Fly   520 GDEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDLLVKFA-----NKDKEE 568
            ||::.|:| .|.:.......||     :.|....|:.|...||     |.|.|:
  Fly   490 GDDLSYLF-YNSLARKLKNHTR-----EYKCIERLVGLWTHFAACGNPNFDPEQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	139/574 (24%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	67/205 (33%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	139/574 (24%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	37/123 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	4	3.810