DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and Est-P

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	612	Identity:	156/612 - (25%)
Similarity:	262/612 - (42%)	Gaps:	98/612 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPSTGI-YS 75
            ||.|:::.:|:.:|  :|...:..|..||                         .|....|: ||
  Fly     7 LLCLTLLWIAALES--EADPLIVEITNGK-------------------------IRGKDNGLYYS 44

  Fly    76 FLGMHYAEPPVGPLRYSRP-VYKRLAGD-FNATKHGPPCIQPHPQF---PQRIIGDEDCLLLNVY 135
            :..:..||.|.|.||:..| .|.....| ||||:....|:|.: ||   ..:::||||||.:::|
  Fly    45 YESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQWN-QFINENNKLMGDEDCLTVSIY 108

  Fly   136 TPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMAQRGA-IVVAPQYRLGSLGIMGDGTKQFDG 199
            .|:.|:.:: .||.|.:|.|.:.:||.:.|....:.:.|. :||...:.||.||....|.:...|
  Fly   109 KPKKPNRSS-FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPG 172

  Fly   200 NLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVH--------G 256
            |..:.|...||:|:...|::|||.|..:..|||.:|.||| :|.:         :|        |
  Fly   173 NYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASA-HLQL---------LHEDFKHLAKG 227

  Fly   257 VVAMSGTALSQYAMDKEPVQSVQEVAKINGC-PTGNELEIVNCLRSKSAEDIIKNDDKVQTERLA 320
            .:::||.||..:.:.:...:...|:.:|.|| .|....|:.:||:||.|.||:.          |
  Fly   228 AISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVS----------A 282

  Fly   321 GRA-LVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIP-LLTGVTKHETANSVT 383
            .|: ||........|.|.:|..|   |..:.:..:|...:||..|:.:| .:|..|:....|:..
  Fly   283 VRSFLVFSYVPFSAFGPVVEPSD---APDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQ 344

  Fly   384 VETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQALN 448
            :....|:.|  |.::..|:|.......:|    |..:.||..:..:.. |:..|:..:...:..:
  Fly   345 LLERNKLTG--ESWIDLLNDRWFDWAPYL----LFYRDAKKTIKDMDD-LSFDLRQQYLADRRFS 402

  Fly   449 VDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLPIVSETAHDK 513
            |:...: |....|||||.........:..:...:.:|||.|:.....|:.     .::|......
  Fly   403 VESYWN-VQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVG-----QLLSNRTDVH 461

  Fly   514 PETVGHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDLLVKFANKDKEEG----GKSSI 574
            ..|| |||:...      ||......|.:...|:: :....|.:|..||..||  |    |:.:.
  Fly   462 FGTV-HGDDFFL------IFNTAAYRTGIRPDEEV-ISKKFIGMLEDFALNDK--GTLTFGECNF 516

  Fly   575 FQSVTGKATPFIKIDTKLQTSNDF-RF 600
            ..:|..|....::|......:.:: ||
  Fly   517 QNNVNSKEYQVLRISRNACKNEEYARF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	145/560 (26%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	63/192 (33%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	148/583 (25%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	44/143 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	6	5.910