DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and Ces3a

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_941074.1	Gene:	Ces3a / 382053	MGIID:	102773	Length:	571	Species:	Mus musculus

Alignment Length:	573	Identity:	151/573 - (26%)
Similarity:	233/573 - (40%)	Gaps:	129/573 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRPVYKR-L 99
            ::|.|.:: |.||.|:...|     .|..|.::....:..|||:.:|:.|:||||:|.|:..: .
Mouse    29 VIGPKVTQ-PEVDTPLGRVR-----GRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPW 87

  Fly   100 AGDFNATKHGPPCIQPHPQ--------------FPQRIIGDEDCLLLNVYTPQMPDETTG--LPV 148
            .|..:|:.:.|.|:|...:              ||.    .||||.||:|:|  .:.|.|  .||
Mouse    88 EGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPI----SEDCLTLNIYSP--TEITAGDKRPV 146

  Fly   149 FVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRW 212
            .||||.|....||:..:|.:.:|..| .:||..|||||..|.:..|.|...||....|:.|||||
Mouse   147 MVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRW 211

  Fly   213 VTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQS 277
            |...|:.|||:|..|...|:.:|......|.:||  .|||..|..::.||..:|:...|......
Mouse   212 VQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSP--MSAGLFHRAISQSGVVISKILEDLNAWSE 274

  Fly   278 VQEVAKINGCPTGNELEIVNCLRSKSAEDII-KNDDKVQTERLAGRALVKGLTGNVGFQPHIESE 341
            .|..|....|.:.:..|:|.||..|..:|:| |.:..:            ..|.|..|.|.
Mouse   275 AQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNI------------SYTVNDSFFPQ---- 323

  Fly   342 DDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLN 406
                        .|::.|.:..|..:|.|.|||.||             ||.......::.|.:.
Mouse   324 ------------RPQKLLANKQFPTVPYLLGVTNHE-------------FGWLLLKFWNILDKME 363

  Fly   407 KLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSK-VVESTT-----DVLF 465
            .|:....::.....:|..:||   ..:.||:           :|:.|.. ..||.|     ::|.
Mouse   364 HLSQEDLLENSRPLLAHMQLP---PEIMPTV-----------IDEYLDNGSDESATRYALQELLG 414

  Fly   466 NLPAVLTTQVWSRL-----APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETV--GHGDEI 523
            ::..|:.|.::|:.     .|.|:|.|::  |.|....|             ||..|  .|..|.
Mouse   415 DITLVIPTLIFSKYLQDAGCPVFLYEFQH--TPSSFAKF-------------KPAWVKADHSSEN 464

  Fly   524 GYMFDANDIFGNPM--EETRLTSAEDLKVRNNLIDLLV-----KFANKDKEEG 569
            .:      :||.|.  :|:.|.:..:.......:.|.:     :||......|
Mouse   465 AF------VFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNG 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	144/547 (26%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	71/196 (36%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	149/566 (26%)
		Aes	75..>245	CDD:223730	62/175 (35%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910