Protein Alignment CG5397 and AADACL2

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 86/381 - (22%)
• Similarity: 128/381 - (33%)
• Gaps: 119/381 - (31%)

  Fly   132 LNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQ--------YDATPMAQRGAIVVAPQYRLGSLG 188
            :.:|.|:...||....| ::.|.||:.:||:.|        :.|..:   .|:||...|||..
Human    91 VRLYLPKRKSETRRRAV-IYFHGGGFCFGSSKQRAFDFLNRWTANTL---DAVVVGVDYRLAP-- 149

  Fly   189 IMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGD 253
             ......||:..||........:.:|.|    |.:|.::...|..||...|
Human   150 -QHHFPAQFEDGLAAVKFFLLEKILTKY----GVDPTRICIAGDSSGGNLA-------------- 195

  Fly   254 VHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTER 318
                     ||::         |.||           |:.|             ||:..|:|.
Human   196 ---------TAVT---------QQVQ-----------NDAE-------------IKHKIKMQV-- 216

  Fly   319 LAGRALVKGLTGNVGFQP-HIESE-------DDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTK 375
                .|..||.....:.| |.|:|       |....|.||...:.|         .:|......:
Human   217 ----LLYPGLQITDSYLPSHRENEHGIVLTRDVAIKLVSLYFTKDE---------ALPWAMRRNQ 268

  Fly   376 HETANS-----------VTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGL 429
            |....|           :..|...|.:...|..||.||.||..||....:..|........|| |
Human   269 HMPLESRHLFKFVNWSILLPEKYRKDYVYTEPILGGLSYSLPGLTDSRALPLLANDSQLQNLP-L 332

  Fly   430 TSVLT---PTLQD--VWKVPQALNVD-QVLSKVVESTTDVLFNLPAVLTTQVWSRL 479
            |.:||   ..|:|  :..|.:..||. ||:.:.:|   |.:....:.:|:..:.||
Human   333 TYILTCQHDLLRDDGLMYVTRLRNVGVQVVHEHIE---DGIHGALSFMTSPFYLRL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	86/381 (23%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	79/350 (23%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)