DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and CG4382

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	158/599 - (26%)
Similarity:	261/599 - (43%)	Gaps:	139/599 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDP----------VIFARLFDRDARVEGFRNPS- 70
            |::|....||.::...:.:.:       |..:||          ||...|    .::.|...||
  Fly     8 VLLLCGLASGQNSDEDLSKAI-------PDEEDPIGSNKELSDLVITTAL----GKIRGTILPSQ 61

  Fly    71 --TGIYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPHPQFPQRIIGD--EDCL 130
              ...|:|.|:.||:|||..||:..| ..::.....:||..||.|    ||. ..:.||  ||||
  Fly    62 SGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKC----PQL-GLVSGDVSEDCL 121

  Fly   131 LLNVYTPQMPDET---TGLPVFVWIHPGG-YRYGSAAQYDATP--MAQRGAIVVAPQYRLGSLGI 189
            .:|:||.::|.|:   ...||.|:||||| |.....::..|.|  ...|..::|...|||||||.
  Fly   122 RVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYRLGSLGF 186

  Fly   190 MGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDV 254
            :..||::..||:.:.|....||||..:||.|||:|..:..:|:|:||.:.....:||.||  |..
  Fly   187 LATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSR--GLF 249

  Fly   255 HGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKV-QTER 318
            |..:.|||....|:::....:....:.|.:..|.|.|..|:::||:.|...:......|: :.:|
  Fly   250 HKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDCLKGKHYLEFANTLPKMFEFDR 314

  Fly   319 LAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSVT 383
              ...|:.       ::|.|| .|.|:  ...:|.||.:..::.:|..:|::||:||
  Fly   315 --NNPLIL-------WKPVIE-PDFGQ--ERFLVEEPIRSYQNDDFMKVPIITGMTK-------- 359

  Fly   384 VETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKV----- 443
                       ::|:|   .:|:.|.|                |.|.|.|....:.:..|
  Fly   360 -----------DEFVG---PALSILQS----------------PTLLSALNENFESLAPVFFMYN 394

  Fly   444 ---PQALNVDQVL------SKVVES--TTDVLFNLPAVLTT--------QVWSRLAPAFMYSFEY 489
               .:|.|:.|.|      .|::::  :.:.|.||.:...|        .:.:|....:.|.|.|
  Fly   395 TSDARACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSY 459

  Fly   490 NGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNL 554
            .|.:|. |.:          ..|.|..|.|.|::.|:|....|       :|:.:.:|.:.|  :
  Fly   460 QGARSH-IYY----------PEDAPYGVVHHDDLMYLFVEPSI-------SRMFTEDDDEFR--M 504

  Fly   555 IDLLVK----FANK 564
            :|::|:    ||.|
  Fly   505 VDIMVRMFSAFAYK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	148/544 (27%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	70/187 (37%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	151/559 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	6	5.910