DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and CG3841

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	161/577 - (27%)
Similarity:	250/577 - (43%)	Gaps:	116/577 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DDPVIFARLFDRDARVEGFRNPSTG---IYSFLGMHYAEPPVGPLRYSRPVYKRLAGD--FNATK 107
            ||||:...|    .|::|....|.|   ||:|.|:.||:.|||.||::.||.:...||  ||||.
  Fly    27 DDPVVELSL----GRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATS 87

  Fly   108 HGPPCIQPHPQFPQRIIG--DEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSA-AQYDATP 169
            ....|.||      .::.  .||||.:||:|....|:   .||.|:||.|....||. :.|:|.|
  Fly    88 DSLVCPQP------GVVSLMSEDCLKINVFTKSFEDK---FPVMVYIHGGANVLGSGHSSYEAGP 143

  Fly   170 --MAQRGAIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGH 232
              :..:..:.||..||||:||.:...:.:..||....|...||.||.|:||:|||:|:.|..||.
  Fly   144 QYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGI 208

  Fly   233 GSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVN 297
            .:|:.:......||.  |||..|..:.|||:|.:.:.:|.  :...:::|:..|||..:..::|.
  Fly   209 SAGSMAVSLHLASPL--SAGLFHRAILMSGSATNHFDIDN--LFWTRKLARELGCPMYDPTDVVE 269

  Fly   298 CLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSS 362
            |||:::...|::.....:|.:|.          |:.:...|    ||..|.:    .|.:.:|..
  Fly   270 CLRNETWTRIVEVCKAWETYQLV----------NMKWNYEI----DGHFLHN----HPTELIKEG 316

  Fly   363 NFSGIPLLTGVTKHE---TANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFL-KIDKLTGQIAK 423
            ||:.:|||...|.:|   .|| |.:|....:...|..|:    |...:|  || :.|...|:..|
  Fly   317 NFNKVPLLISFTANEFDYNAN-VHLENQHLLHDFASNFV----DYAPEL--FLYRHDAQIGEKLK 374

  Fly   424 PELPG--LTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYS 486
            ....|  .|.:.:..::         |..|:.|       |...........|:.|...|.:...
  Fly   375 DFYLGDNTTEINSENIE---------NFGQIFS-------DAYIGHGVHRLVQLASHFTPVYYTR 423

  Fly   487 FEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVR 551
            .:|.|.:|      ...|:..|   :||..|||.|::.|:...  .:..|     |.:|.|
  Fly   424 MDYVGDQS------LSAPLNGE---NKPVGVGHADDLHYVLPG--YWYGP-----LMAAND---- 468

  Fly   552 NNLIDLLVKFANKDKEEGGKSSIF--QSVTGKATPFIKIDTKLQTSNDFRFCELSVL 606
                                |.:|  :.:|...|.|.|..|.|.:::.:..|..:||
  Fly   469 --------------------SDVFMMERLTSWFTHFAKTGTPLNSTDIWPPCNSTVL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	153/555 (28%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	68/185 (37%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	161/577 (28%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	44/123 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	5	4.810