DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and Ces5a

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	156/578 - (26%)
Similarity:	237/578 - (41%)	Gaps:	110/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DDPVIFARL---FDRDARVEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRPVYKRLAGDF-NATKH 108
            ::|..:.||   ..:.|.|.|...|   :..|||:.:|.||:||||:|.|.......|. .||.:
  Rat    29 EEPHRYTRLGWVQGKQATVLGRLEP---VNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTY 90

  Fly   109 GPPCIQP-----------HPQFPQRIIG-DEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGS 161
            ...|.|.           ...:|:  :| .||||.||:|.|...::.:.|||.:||..||:..||
  Rat    91 PNVCFQNLEWLFIYQNLLKVHYPK--LGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGS 153

  Fly   162 AAQYDATPM-AQRGAIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPK 225
            |:.:|.:.: |....::|..|||||..|......:...||.|..|..|||:||.:.|:||||||.
  Rat   154 ASIFDGSALAAYEDVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPD 218

  Fly   226 QVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTAL--SQYAMDKEPVQSVQEVAKINGCP 288
            .|...|..:||.|...|.:||.  |||..|..:..||.|:  |....|.|....:|.||.:..|.
  Rat   219 SVTIFGGSAGAISISSLILSPL--SAGLFHRAIMQSGVAIIPSLKNFDDELKHGLQVVADVCKCN 281

  Fly   289 TGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVG 353
            ..:...::.|||.||:.:::....|           .|..|..|          ||...|.
  Rat   282 VSDSKVLLKCLREKSSLELLSLGQK-----------TKAFTRVV----------DGSFFPE---- 321

  Fly   354 EPEQQLKSSNFSGIPLLTGVTKHETANSVTV-ETIEKVFGSAEQFLGSLSDSLNKLTSFLKI-DK 416
            ||.:.|....|..:|.:.||...|....:.: |..|.:|||.|      |.:|..:...|.| .:
  Rat   322 EPMELLSQKTFKTVPSIIGVNNQECGYILPMREAPEILFGSNE------STALTLIHVLLHIPPQ 380

  Fly   417 LTGQIAKPELPGLTSV--LTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRL 479
            ....:||....|..|:  :..||.|::                   .||.|.:|.::|.:.....
  Rat   381 YMHIVAKDYFHGKHSLTDIRDTLLDLF-------------------GDVFFVVPGLVTARNHRDA 426

  Fly   480 -APAFMYSFEY--NGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETR 541
             .|.:.|.|::  |..::....|:|               ..|.|||.:      :||.|..|..
  Rat   427 GGPVYFYEFQHRPNCFQNTRPAFVK---------------ADHTDEIRF------VFGGPFLEGD 470

  Fly   542 LT----SAEDLK-VRNNLIDLLVKFANKDKEEGGKSSIFQSVTGKATPFIKIDTKLQT 594
            :.    :.||.| :...::.....||......|....::.:.....: ::|:|..:.|
  Rat   471 VVMFEEATEDEKLLSRKMMSYWANFARSGDPNGDDLPLWPAYDQNES-YLKLDVNIST 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	152/561 (27%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	71/192 (37%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	153/567 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910