DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and Ces2g

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	153/562 - (27%)
Similarity:	230/562 - (40%)	Gaps:	112/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPSTGIY 74
            |||||:.|                       |.:..|...|:..........::...::..:|::
  Rat    17 LLLLLIHV-----------------------QGQHSPESSPIRNTHTGQVQGKLTHSKDFKSGVH 58

  Fly    75 SFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPHPQFPQR---------------- 122
            :|||:.:|:.||||||::.| ..:..:|..:.|.....|       ||.
  Rat    59 TFLGIPFAKAPVGPLRFAPPEAPEPWSGVRDGTSQSNIC-------PQNVRMNMEGLKEMKLTLP 116

  Fly   123 -IIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPM-AQRGAIVVAPQYRLG 185
             :...||||.||:|.|....|.:.|||.||||.|....|.|:.||.:.: |....:||..|||||
  Rat   117 PVSMSEDCLYLNIYAPAHAHEGSHLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVTIQYRLG 181

  Fly   186 SLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRS 250
            .||....|.....||....|..||||||...|::|||||..|...|..:|..|.....:||.|:
  Rat   182 VLGFFSTGDHHARGNWGYLDQVAALRWVQQNIAHFGGNPDCVTIFGESAGGLSVSSHVVSPMSK- 245

  Fly   251 AGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQ 315
             |..|..:..||.||....:........|.|.|::||...:...:|:|||.||.|.|.....:.|
  Rat   246 -GLFHRAIMESGVALMPGTIFNFSEMVYQMVVKLSGCEAMDPESLVHCLRGKSEEQITVISKEFQ 309

  Fly   316 TERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETAN 380
            .                     |.:..||..||:    .|::.|.|::|..:|.:.|....|..
  Rat   310 M---------------------IPAVVDGEFLPN----HPQELLASADFHPVPSIIGFNNDEYG- 348

  Fly   381 SVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQ 445
                ..:.||.|||:...|...::|.   :||| |.....:..||...|  ::...:.|: :.||
  Rat   349 ----WIVPKVIGSAQTIKGITRENLQ---AFLK-DTAPQMMLPPECSDL--LMEEYMGDI-EDPQ 402

  Fly   446 ALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLPIVSETA 510
            .|.     ::..|...|.:|.:|::...:.....||.:.|.|::..      :|||.:    ...
  Rat   403 TLQ-----AQFTEMMEDFMFVIPSLQVARFQRSHAPVYFYEFQHQS------SFLKDI----RPP 452

  Fly   511 HDKPETVGHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVRN 552
            |.|.:   ||||:.:      :||:.....:|...|..|:.|
  Rat   453 HVKAD---HGDEVPF------VFGSFFWGMKLNLTEGEKLLN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	144/510 (28%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	69/197 (35%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	145/525 (28%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	43/102 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910