DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and Ces1a

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001013786.2	Gene:	Ces1a / 244595	MGIID:	3648919	Length:	563	Species:	Mus musculus

Alignment Length:	592	Identity:	155/592 - (26%)
Similarity:	255/592 - (43%)	Gaps:	139/592 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPSTGIYSF 76
            |..|::..|.:|.:.|  |:           .:|||.| .:..::..:...:||...|   :..|
Mouse     3 LFALALASLNTCMALG--HL-----------SSPPVVD-TLQGKVMGKYISLEGSAQP---VAVF 50

  Fly    77 LGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPHPQFPQRIIGD-------------- 126
            ||:.:|:||:||||::.| ..:..:...|.|.:.|.|.|.....|  ::.|
Mouse    51 LGVPFAKPPLGPLRFAPPQPAETWSSVKNTTSYPPMCSQITGVGP--VLSDVFTNQLENVPLEYS 113

  Fly   127 EDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMA-QRGAIVVAPQYRLGSLGIM 190
            ||||.||:|:|........|||.||:|.||...|.|:.:|...:: ....::|..|||||..|.:
Mouse   114 EDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGASTFDGLALSTHENVVIVVIQYRLGIWGFL 178

  Fly   191 GDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVH 255
            ..|.:...||....|..|||:||.:.|:.|||:|..|...|..:|..|...|.:||.:::.  ..
Mouse   179 STGDEHSRGNWGHLDQVAALQWVQNNIANFGGDPSSVTLFGESAGGESVSVLVLSPLTKNL--FQ 241

  Fly   256 GVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLA 320
            ..::.||.||:.....:...::.::||...||......:||:|||.|:.|:::....|::...|
Mouse   242 RAISESGVALTPCLFRETTRRAAEQVAIATGCVATTSADIVHCLREKTEEELLATTLKMKFFAL- 305

  Fly   321 GRALVKGLTGNV-GFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSVTV 384
                  .|.|:. ...|.:.:..||..||.    .||:.|...:|:.:|.:.|:.|.|
Mouse   306 ------DLLGDPRESYPFLTTVIDGVVLPK----APEEILAEKSFNTVPYIVGINKQE------- 353

  Fly   385 ETIEKVFG-SAEQFLG-SLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQAL 447
                  || .....:| .||:.        |:|:.:.          ||:|       ||.....
Mouse   354 ------FGWFIPMMMGYPLSEG--------KLDQKSA----------TSLL-------WKSYPLT 387

  Fly   448 NVDQVLSKV-------------------VESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGT 492
            |:.:.|:.|                   ::...||||.:|:|:..:..... ||.:||.|:|:.:
Mouse   388 NISKELTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSVIVARYHRDAGAPTYMYEFKYHPS 452

  Fly   493 KSKGINFLKGLPIVSETAHDKPETV--GHGDEIGYMFDANDIFGNP-MEETRLTSAEDLKVRNNL 554
                        .||:.   :|:||  .||||:      ..::|.| ::|.  .|.|::    ||
Mouse   453 ------------FVSDM---RPKTVIADHGDEV------YSVWGTPFLKEG--ASEEEI----NL 490

  Fly   555 IDLLVKF 561
            ..:::||
Mouse   491 STMMMKF 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	145/542 (27%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	62/194 (32%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	147/557 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910