Protein Alignment CG5397 and NLGN1

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 156/628 - (24%)
• Similarity: 249/628 - (39%)
• Gaps: 157/628 - (25%)

  Fly    49 DPVIFARLFDRDARVEGFR----NPSTG-IYSFLGMHYAEPPVGPLRYSRPVYKRLAGDF-NATK 107
            ||::....    .::.|.:    |...| :..|||:.||.||.|..|:..|.......|. |||:
Human    52 DPLVATNF----GKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQ 112

  Fly   108 HGPPCIQPHPQFPQRIIG--------------------------DEDCLLLNVYTP--------- 137
            ..|.|       ||.||.                          .||||.||:|.|
Human   113 FAPVC-------PQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKK 170

  Fly   138 --------------QMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSL 187
                          .:.|.....||.|:||.|.|..|:...||.:.:|..| .||:...||||.|
Human   171 QTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVL 235

  Fly   188 GIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTS---R 249
            |.:..|.:...||..:.||..||||.::.|.:|||:|.::...|.|:|.:....|::|..|   |
Human   236 GFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNR 300

  Fly   250 SAGDVHGV----VAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKN 310
            .:....|:    :|.||||||.:|:..:|.:..:.:|...||...:.:|:|.||:.|..::::
Human   301 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELV-- 363

  Fly   311 DDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTK 375
            |..:|..|.           ::.|.|.|    ||..:|.    :|:..::...|....::.||.:
Human   364 DQDIQPARY-----------HIAFGPVI----DGDVIPD----DPQILMEQGEFLNYDIMLGVNQ 409

  Fly   376 HETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDV 440
            .|     .::.:|.:..|.:..  |.||....:::|  :|.|.|      .|....||..|::.:
Human   410 GE-----GLKFVENIVDSDDGI--SASDFDFAVSNF--VDNLYG------YPEGKDVLRETIKFM 459

  Fly   441 ---WKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLK 501
               |  ....|.:.....::...||..:..|||.|..:.|.. :|.:.|:|.::....:
Human   460 YTDW--ADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQ------ 516

  Fly   502 GLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPM-EETRL----TSAEDLKVRNNLIDLLVKF 561
             :|..::.|        ||||:.|      :.|.|| ..|.|    .|..|:.:...::.....|
Human   517 -VPAWADAA--------HGDEVPY------VLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNF 566

  Fly   562 ANKDKEEGGKSSIFQSVTGKATPFIKIDTKLQTSNDFRFCELS 604
            |.               ||.....:..|||...:...||.|::
Human   567 AK---------------TGDPNQPVPQDTKFIHTKPNRFEEVA 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	153/621 (25%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	156/628 (25%)