Protein Alignment CG5397 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 150/610 - (24%)
• Similarity: 248/610 - (40%)
• Gaps: 152/610 - (24%)

  Fly    62 RVEGFRNPSTG-----IYSFLGMHYAEPPVGPLRYSRPVY-KRLAGDFNATKHGPPCIQP----- 115
            :::|.|.|...     :..:||:.||.||.|..|:..|.. ....|..|||:....|.|.
Human    54 KIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERF 118

  Fly   116 --HPQFP----------QRIIGD--EDCLLLNVYTP-----------------------QMPDET 143
              |...|          ...:.|  ||||.||:|.|                       .:.::.
Human   119 LLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQN 183

  Fly   144 TGLPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLA 207
            :..||.|:||.|.|..|:....|.:.:|..| .||:...||||.||.:..|.:...||..:.|..
Human   184 SKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQI 248

  Fly   208 AALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDK 272
            .||||:.:.:..|||:||:|...|.|:||:....|::|  ..|.|.....:..||||||.:|::.
Human   249 QALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS--HYSEGLFQKAIIQSGTALSSWAVNY 311

  Fly   273 EPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPH 337
            :|.:..:.:|...||...:..::|.||::|:.:::|:     ||        :...|.::.|.|.
Human   312 QPAKYTRILADKVGCNMLDTTDMVECLKNKNYKELIQ-----QT--------ITPATYHIAFGPV 363

  Fly   338 IESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLS 402
            |    ||..:|.    :|:..::...|....::.||.:                |...:|:..:.
Human   364 I----DGDVIPD----DPQILMEQGEFLNYDIMLGVNQ----------------GEGLKFVDGIV 404

  Fly   403 DSLNKLT---------SFLKIDKLTGQIAKPELPGLTSVLTPTLQDV---WKVPQALNVDQVLSK 455
            |:.:.:|         :|  :|.|.|      .|.....|..|::.:   |...:  |.:.....
Human   405 DNEDGVTPNDFDFSVSNF--VDNLYG------YPEGKDTLRETIKFMYTDWADKE--NPETRRKT 459

  Fly   456 VVESTTDVLFNLPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGH 519
            :|...||..:..|||.|..:.::. :|.:.|:| |:..:|:    :|  |..:::|        |
Human   460 LVALFTDHQWVAPAVATADLHAQYGSPTYFYAF-YHHCQSE----MK--PSWADSA--------H 509

  Fly   520 GDEIGYMFDANDIFGNPM-EETRLTSA----EDLKVRNNLIDLLVKFANKDKEEGGKSSIFQSVT 579
            |||:.|      :||.|| ..|.|.|.    .|:.:...::.....||.               |
Human   510 GDEVPY------VFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAK---------------T 553

  Fly   580 GKATPFIKIDTKLQTSNDFRFCELS 604
            |.....:..|||...:...||.|::
Human   554 GDPNQPVPQDTKFIHTKPNRFEEVA 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	147/603 (24%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	150/610 (25%)