Protein Alignment CG5397 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 678
• Identity: 176/678 - (25%)
• Similarity: 266/678 - (39%)
• Gaps: 198/678 - (29%)

  Fly    12 LLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAP---------------PVDDPVIFARLFDRDA 61
            ||.|.:|.||..:.||          ||....||               ||.:...        .
Mouse     3 LLALCLVGLAGAQRGG----------GGPGGGAPGGPGLGLGSLGEERFPVVNTAY--------G 49

  Fly    62 RVEGFR----NPSTG-IYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPHPQFP 120
            ||.|.|    |...| :..|||:.||.||:|..|:..| ......|..|||...|.|       |
Mouse    50 RVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPAC-------P 107

  Fly   121 QRIIG-------------------------DEDCLLLNVYTP-------QMPDETT--------- 144
            |.:.|                         .||||.||:|.|       :..||.|
Mouse   108 QNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIR 172

  Fly   145 ---GLPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQYRLGSLGIMGDGTKQFDGNLAMFD 205
               ..||.:::|.|.|..|:...:|.:.:|..| .|||...||||.||.:..|.:...||..:.|
Mouse   173 DSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLD 237

  Fly   206 LAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAM 270
            ...||||:::.|::|||:|:::...|.|:||:....|.:|  ..|.|.....:|.||||:|.:::
Mouse   238 QIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILS--HHSEGLFQKAIAQSGTAISSWSV 300

  Fly   271 DKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQ 335
            :.:|::..:.:|...||...:..|.|.|||.||:.:::  |..||..|.           ::.|.
Mouse   301 NYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSRELV--DQDVQPARY-----------HIAFG 352

  Fly   336 PHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKHETANSV--TVETIEKVFGSAEQFL 398
            |.:    ||..:|.    :||..::...|....:|.||.:.|....|  :.|:.:.|..||..|
Mouse   353 PVV----DGDVVPD----DPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDF- 408

  Fly   399 GSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDV---WKVPQALNVDQVLSKVVEST 460
                    .:::|  :|.|.|      .|....||..|::.:   |       .|:...::...|
Mouse   409 --------TVSNF--VDNLYG------YPEGKDVLRETIKFMYTDW-------ADRDNGEMRRKT 450

  Fly   461 TDVLFN-----LPAVLTTQVWSRL-APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPE--TV 517
            ...||.     .|||.|.::.:.. :|.:.|:| |:..:::|                :||  ..
Mouse   451 LLALFTDHQWVAPAVATAKLHADYQSPVYFYTF-YHHCQAEG----------------RPEWADA 498

  Fly   518 GHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDLLVKF-ANKDKEEGGKSSIFQSV--- 578
            .||||:.|      :||.||     ..|.||            | .|..|.:...|::..:.
Mouse   499 AHGDELPY------VFGVPM-----VGATDL------------FPCNFSKNDVMLSAVVMTYWTN 540

  Fly   579 ---TGKATPFIKIDTKLQTSNDFRFCEL 603
               ||.....:..|||...:...||.|:
Mouse   541 FAKTGDPNQPVPQDTKFIHTKPNRFEEV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	159/621 (26%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	164/629 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836