DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and cest-19

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_509187.4	Gene:	cest-19 / 180973	WormBaseID:	WBGene00020125	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	154/569 - (27%)
Similarity:	235/569 - (41%)	Gaps:	143/569 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 YS-FLGMHYAEPPVGPLRYSRPVYKRLA---GDFNATKHGPPCIQPHPQ----FPQRIIG--DED 128
            || |.|:.:|.||||.||:..|  |..|   |..|||::...|:|...:    .|:|.:.  .||
Worm    47 YSVFKGIPFAMPPVGYLRFQMP--KEPAKWRGVMNATQYSAMCMQNIDENDAGEPERYVAHVSED 109

  Fly   129 CLLLNVYTP---QMPDETTGLPVFVWIHPGGYRYGSAAQYD----ATPMAQRGAIVVAPQYRLGS 186
            ||.|||::|   |..::|  .||.|:||.|.::.||.:...    .:....|..:.|...||||.
Worm   110 CLYLNVFSPTPYQYTNDT--YPVIVFIHGGRFQTGSGSDIPQRAILSNFVSRKIVFVTFNYRLGP 172

  Fly   187 LGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSA 251
            ||....|.....||:.::|...||:||......|||:|..:..:|||:|||||..|::||  |:.
Worm   173 LGFASTGDSVLPGNIGLWDQIWALKWVKANAEVFGGDPSNILLMGHGTGAASASLLALSP--RAE 235

  Fly   252 GDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQT 316
            |....|:.|||:||....:....|.:...:....||...|..|:::|.|.:|.|:|.      |.
Worm   236 GLFQKVLLMSGSALQPGVVRNTQVNATWNMNDRFGCRAFNSSELLDCARKRSKEEIF------QY 294

  Fly   317 ERLAGRALVKGLTGNVGFQPHIESEDD--------GRALPSLIVGEPEQQLKSSNFSGIPLLTGV 373
            :||                 |.:..::        |..||     ||.:|| :.:....|::.|.
Worm   295 KRL-----------------HFDDYEEFVPIIDGVGGILP-----EPPEQL-TLHRRKTPIVIGT 336

  Fly   374 TKHETA-------------NSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPE 425
            ||.|::             :|:|.|..|           :|:|:|.......:..:|..|..|.|
Worm   337 TKDESSLRILLLNEKDLNFSSITWENGE-----------TLADNLTLGFKQFQNHRLISQGCKSE 390

  Fly   426 LPGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVW-----SRLA----- 480
            .             ||        .||.....||   ||||....:.:..|     |:||
Worm   391 Y-------------VW--------TQVDPSFPES---VLFNSLLKMYSHFWYDAPASQLATYYLK 431

  Fly   481 ---PAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETRL 542
               |.::|||::                :||..:| .:...||.:..::|:....|.|..::  :
Worm   432 HDLPVYLYSFDH----------------ISENFYD-IDRAFHGVDKLHIFNVTPRFLNKRKD--M 477

  Fly   543 TSAEDLKVRNNLIDLLVKFA---NKDKEEGGKSSIFQSVTGKATPFIKI 588
            ....|.:|.....:|:..||   ....|..|.|..:.|.|.|...::.|
Worm   478 NWQLDQRVVEIFSELVANFALYGTPTHENDGFSFNWTSTTAKELSYLSI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	154/569 (27%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	70/194 (36%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	154/569 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910