DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and cest-26

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001368609.1	Gene:	cest-26 / 180715	WormBaseID:	WBGene00017478	Length:	585	Species:	Caenorhabditis elegans

Alignment Length:	615	Identity:	159/615 - (25%)
Similarity:	247/615 - (40%)	Gaps:	162/615 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RDARVEGFR---NPSTGIYSFLGMHYAEPPVGPLRYSRPVYKRLAGDFNATKHGPPCIQPHPQFP 120
            |:..|||||   :....:..|||:.:|:.|||.||:..|.:..   |::..|   .|::..|:.|
Worm    47 RNGLVEGFRIKIDDDREVDMFLGIPFAKAPVGDLRFKNPEHTE---DWDGVK---KCVRFGPRAP 105

  Fly   121 QR-------IIG---DEDCLLLNVYTPQMPDE--TTGL-PVFVWIHPGGYRYGSAAQYD----AT 168
            |.       .:|   .||||.|||::|....|  :.|| ||.|::|.||:...||.:|.    |.
Worm   106 QADFFWERFTLGVGKSEDCLYLNVFSPTWKAEEVSNGLHPVMVYVHGGGFLIDSAVKYGDEGIAK 170

  Fly   169 PMAQRGAIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHG 233
            .:.:.|.:||..|||||.||....|.:...|||.::|:..||:||.|.:..|||:|::|...|..
Worm   171 YLCRHGVVVVTIQYRLGLLGFFSTGDQVCPGNLGLWDMTMALQWVRDNVHAFGGDPRKVTVFGQS 235

  Fly   234 SGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNC 298
            :|..|...||:||.||..  .|.||.|:|....:::       :|.:...:|.|   .|.....|
Worm   236 AGGVSVDLLSLSPHSRDL--FHQVVPMAGNGECEWS-------TVGKNRLVNAC---REFAYRKC 288

  Fly   299 LRSKSAEDIIKNDD-----KVQTERLAGRALV--KG---------LTGNVGFQP------HIESE 341
            ...|.|.|...::.     :.:.||...:.|:  ||         |...:|.:|      .||..
Worm   289 WDEKQARDENASESMLEFLRTRKEREFEKRLLTRKGVDVSKIGLDLAPVIGSKPSDFLPKSIEEL 353

  Fly   342 DDGRALPSLIVGEPEQQ------LKSSNF--SGI----PLLTGVTKHETANSVTVETIEKVFGSA 394
            .......:::||..|.:      |..|||  .||    .||.....||...::..|       :.
Worm   354 RKEAPKKNIMVGTCEHEGLLFASLGPSNFDEKGIDKLLALLITEENHEDFEALREE-------AK 411

  Fly   395 EQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSK-VVE 458
            :.:|..|||.        :.||                                  :|.:: .::
Worm   412 KMYLKKLSDD--------EDDK----------------------------------EVAARGYIQ 434

  Fly   459 STTDVLFNLPAVLTTQVWSRLA-PAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDE 522
            ..:|:..|.......:..::|. ..|||||:|...:|.||..|:. |..:.|         |..|
Worm   435 LYSDLFVNNGTYNYAEKMTKLGNKVFMYSFDYCNPRSFGILSLRA-PFRAAT---------HCTE 489

  Fly   523 IGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDLLVK----FANKDKEEG--GKSSIFQ---SV 578
            :.|:|..:.:|.....|:          ...::||:.|    ||......|  ..|::|.   ..
Worm   490 LAYIFGVSIVFNYRYNES----------DRAMLDLMTKMWTNFAKYGNPNGQYEDSTVFDFKWEP 544

  Fly   579 TGKATP--FIKIDTKLQTSNDFRFCELSVL 606
            |.|..|  |:.|:.|.        ||:..:
Worm   545 TSKEEPTNFLAINEKK--------CEMQTV 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	156/604 (26%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	72/195 (37%)
cest-26	NP_001368609.1	COesterase	40..575	CDD:395084	159/615 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910