DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and cest-1.1

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_506506.1	Gene:	cest-1.1 / 179915	WormBaseID:	WBGene00011362	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	139/571 - (24%)
Similarity:	219/571 - (38%)	Gaps:	164/571 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKRNTLLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNP 69
            ||..|:|||:...|    ||       ||:...|..:.|...:.    ::.|.::.|.|
Worm     2 LKPATVLLLIQMYV----CK-------RVQLSSGTIEGKILNIS----YSPLGNQSATV------ 45

  Fly    70 STGIYSFLGMHYAEPPVGPLRYSRP-------------VYKRLAGDFNAT-----KHGPPCIQPH 116
                  |||:.:.|||:|.|||.:|             .||. |...|||     |.|.|.
Worm    46 ------FLGIPFVEPPIGDLRYRKPRPPKSWEGVLVTNEYKS-ACMSNATKTYKNKFGGPI---- 99

  Fly   117 PQFPQRIIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMAQ------RGA 175
                     .||||.|||.|.:...|.....|.:.:|.|||...||:.::...:..      |..
Worm   100 ---------SEDCLYLNVLTNEYCLENKNCSVMMIVHGGGYLTESASTFNPEILINNFVGQGRNI 155

  Fly   176 IVVAPQYRLG--SLGIMGDGTKQFDG-----NLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHG 233
            :||...||||  |.|       ||:|     |..::|:..::.||...|..||||..::...||.
Worm   156 VVVTFNYRLGLFSFG-------QFNGDRGDKNFGLYDMIESVNWVRREIENFGGNKNRITLAGHS 213

  Fly   234 SGAASAMYLSMSPTSRSAGDVHGVVAMSG--TALSQYAMDKEPVQSVQEVAKINGCPTG------ 290
            :||:..:..:.||.::  |.||..:.||.  |.:|:    |...:.:..:|::.||.:.
Worm   214 AGASMIVAFTSSPLTK--GLVHQQIIMSAPMTNMSK----KSNFKGMTVMAQMVGCLSEEIGFNK 272

  Fly   291 -NELEIVN---CLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLI 351
             :|.::.|   |||.|||:.|:.          |...|::..|..:|..|..|         ..:
Worm   273 LSEEQVENTYSCLRKKSAQQILD----------AQLWLLQNSTYFLGAPPIDE---------HFL 318

  Fly   352 VGEPEQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAE-QFLGSLSDSLNKLTSFLKID 415
            ...||....|.:...|..|.|.|..|...|..:  |:..|...: :.|.:|.|.:..:. :.:.:
Worm   319 TDYPENLYASKSIYPINTLIGTTTLEVEESSYI--IDPAFADKKVELLENLCDHIGYVL-YEEPE 380

  Fly   416 KLTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAV-LTTQVWSRL 479
            ..:.:..|..:.|                   |....||..:|      |..||: ......|..
Worm   381 TFSKKCQKQYMNG-------------------NSSMNLSNEME------FYTPAIDFADSHTSGN 420

  Fly   480 APAFMYSFEYNGTKSKGINFLKGLPIVSETAHDK---PETVGHGDEIGYMF 527
            ...|:||::|.|               :..|:|:   ..:..|.:::.|:|
Worm   421 TKVFLYSYDYRG---------------AGPAYDRYLEVRSPHHSEDLIYVF 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	124/514 (24%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	63/209 (30%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	129/543 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910