DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5397 and cest-4

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_501043.1	Gene:	cest-4 / 177445	WormBaseID:	WBGene00015930	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	598	Identity:	127/598 - (21%)
Similarity:	219/598 - (36%)	Gaps:	191/598 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NTLLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPSTG 72
            |.|||.|...::.:..||.                        ::...|    .:::|.:..|..
Worm     9 NNLLLFLSFFLLFSITKSA------------------------IVSTSL----GQIDGDQIGSFH 45

  Fly    73 IYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCIQPH--PQFPQRIIGDEDCLLLNV 134
            ::..:.:  |:||:|.||:.:| ..::..|..||..:||.||...  ...||:.| |||||.:|:
Worm    46 LFKHIPL--AKPPIGKLRFQKPEPPEKWTGVRNAKAYGPACISNSSVSTSPQKWI-DEDCLHINI 107

  Fly   135 YTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDAT----PMAQRGAIVVAPQYRLGSLG-IMGDGT 194
            :|.....::....|..:.|.||..|.||..::.|    ....:..|:..|.:|||... .:.:..
Worm   108 FTSDKCLKSKDCAVVTYFHGGGLMYDSAVMFNDTYLLGTFVNQDVIIAIPAFRLGIFSHFVVEDQ 172

  Fly   195 KQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDV----H 255
            .....|||::|:...:.:|.:.|..||||.::...:||..|.:....|:.|  |:...|:    .
Worm   173 SIAPTNLALYDILLGVEFVKNEIHNFGGNNQKNTIMGHSYGGSIVNILTFS--SKINHDLSLFQQ 235

  Fly   256 GVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPT-----------GNELEIVNCLRSKSAEDIIK 309
            .:...||.......:.   :|.....||..||..           .::|..:.||::|.|.::::
Worm   236 SICMSSGHDFETLEIQ---IQKTNRFAKHAGCTVPSIIEKKMTTRQSDLYRMKCLQNKDALELLR 297

  Fly   310 NDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPS---LIVGEP-------EQQLKSSNF 364
                  .:||.                    ||:|  .|:   |:..||       ::.:||.
Worm   298 ------VQRLL--------------------EDEG--YPTYGYLVQREPLIQEIPYQEFMKSP-- 332

  Fly   365 SGIPLLTGVTKHETANSVTVETIEKVFG---SAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPEL 426
            ..||:|||.|::|..:|...:.|.:..|   ..|.::....|..:::..|
Worm   333 KKIPMLTGCTRYEMDHSPAPKPIGQALGFENPEEVYMKFRKDWDDEVYEF--------------- 382

  Fly   427 PGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEYNG 491
             |..|..|..:.    |...:.|:.:|||.|                       ||::|.:.|
Worm   383 -GNHSDETQAIM----VQVRVRVNNLLSKNV-----------------------PAYLYEYTY-- 417

  Fly   492 TKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMF-------DANDI---------------FG 534
                                  |:...|.|::.|:.       |.|:|               ||
Worm   418 ----------------------PKHARHTDDLFYLMGVHRFEKDENEIELGKVYETIFMNFAKFG 460

  Fly   535 NPMEETRLTSAED 547
            :|.|...|.:||:
Worm   461 DPKEGFELANAEN 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	119/544 (22%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	54/190 (28%)
cest-4	NP_501043.1	Abhydrolase	28..503	CDD:389770	120/555 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810