Protein Alignment CG5397 and cest-5.1

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 680
• Identity: 154/680 - (22%)
• Similarity: 258/680 - (37%)
• Gaps: 208/680 - (30%)

  Fly     8 NTLLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEGFRNPSTG 72
            |||.||||..:|.|:                          |.:|....|   ..:||   ...|
 Worm     2 NTLRLLLLIFIINAA--------------------------DSLIIHTSF---GHLEG---AEIG 34

  Fly    73 IYS-FLGMHYAEPPVGPLRYSRPVYKRLAGDF----NATKHGPPCI--QPHPQFPQRIIGDEDCL 130
            .|. |..:.:|:||||.||:.:|   ..||.:    :|.::||.|:  ....:.||:.: |||||
 Worm    35 DYHLFKKIPFAKPPVGNLRFQKP---EAAGKWDGIRSAIEYGPACMSNSSKTKSPQKWV-DEDCL 95

  Fly   131 LLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPM----AQRGAIVVAPQYRLGSLGIMG 191
            .:|::|.:...::....:.|:||.||..|.||..::.|.:    .:|..|:|.|.:|   |||..
 Worm    96 HVNIFTSKKCLKSRNCAIAVYIHGGGLTYDSAVMFNDTVLLDTFVKRDVILVIPGFR---LGIFS 157

  Fly   192 DGT----KQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGH--GSGAASAMYLSMSPTSRS 250
            ..|    .....|||::|:..||.:|...|..||||.:::...||  |.|.||.|..| |..:|.
 Worm   158 HFTVHNQNVAPNNLALYDITLALEFVKSEIHSFGGNSQKITLFGHSYGGGLASMMTFS-SEINRD 221

  Fly   251 AGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELE-----------IVNCLRSKSA 304
            .......:.|||....:..  |:.::..:...:...|....:||           ::.||:..|.
 Worm   222 LSLFQQAIVMSGGFYFEEL--KDHIEGTKRFVEYANCSVPLKLERKMERSQQEMYMMKCLQKLSG 284

  Fly   305 EDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRA-LPSLIVGEP-------EQQLKS 361
            .::::      .:||.                    ||.|.. ...:|:.||       .:.|||
 Worm   285 MELLR------IQRLL--------------------EDKGYPDFGGVILREPLFPDVKKFELLKS 323

  Fly   362 SNFSGIPLLTGVTKHETANSVTVETIEKVFGS----------AEQFLGSLSDSLNKLTSFLKIDK 416
            .  ..||:|||.|..|..:    |:|:..||.          .|::...:...:....:  ..||
 Worm   324 P--KNIPMLTGCTNLEFDH----ESIKVPFGKYLEFENPDECDEKYRNDVESGVENRGN--HTDK 380

  Fly   417 LTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAP 481
            ..|.|                     :|..|.::.:|...|                       .
 Worm   381 TQGII---------------------LPLKLQINNLLENNV-----------------------T 401

  Fly   482 AFMYSFEY--NGTKSKGINFLKGLPIVSETAHDKPETVGHGDEI--------------GYMFDAN 530
            |::|.:.|  :|..:..::::.|:     .|.:|.|...|.:::              |..|:.:
 Worm   402 AYLYEYTYPKHGRHTDDLSYIMGV-----HAFEKDENEVHLEQVYKDMVINFIKLGEPGMGFEKS 461

  Fly   531 --------DIFGNPM--EETRLTSAEDLKVRNNLIDLLVKFANKDKEEGGKSSIFQSVTGKATPF 585
                    ||:.|..  |..|:....:.:|.:..:..:::|..|..|...|   .:.::.|..||
 Worm   462 EQNESTYFDIYWNETTGERPRMRKYFEKEVTDYWLKEMIEFDQKVTETKKK---LKQISLKTVPF 523

  Fly   586 IKIDTKLQTSNDFRFCEL-SVLGASLSPLS 614
            |:   |....||    |. :::|.||..:|
 Worm   524 IE---KPLEQND----EAGTLIGVSLIAIS 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	140/622 (23%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	129/576 (22%)