DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and cest-5.2

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_501021.3	Gene:	cest-5.2 / 177428	WormBaseID:	WBGene00015284	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	135/562 - (24%)
Similarity:	221/562 - (39%)	Gaps:	151/562 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RVEGFRNPSTGIYS-FLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPCI--QPHPQFPQR 122
            |:||   ..:|.|. |..:.:|:||:|.||:.:| ..::..|.:|||::||.|:  ....|.||:
Worm    30 RLEG---KQSGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPACMSNSTWTQSPQK 91

  Fly   123 IIGDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDAT----PMAQRGAIVVAPQYR 183
            .: |||||.:|::|.....::....|.|:||.|...:.||..::.|    ...::..|:|.|.:|
Worm    92 WV-DEDCLHVNIFTSDKCLKSKDCAVVVYIHGGEIVFDSAVMFNDTFLLESFVKQDVILVIPAFR 155

  Fly   184 LGSLGIMGDGTKQ----FDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGA--ASAMYL 242
               |||....|..    ...|||::|:..|..:|...|..|||:.:::...||..|.  ||.|..
Worm   156 ---LGIFSHFTVHDQNIAPNNLALYDIILAQEFVKSEIHNFGGDIQKITLFGHSYGGTIASMMAF 217

  Fly   243 SMSPTSRSAGDVHGVVAMSGTALSQYAMD--KEPVQSVQEVAKINGC--PTG---------NELE 294
            | |..::.......::.||.   :|| .|  :|.::....|.|..||  ||.         .|..
Worm   218 S-SEINQDLSLFQRIIVMSA---NQY-FDTLEEQIERSDRVVKHAGCSVPTNLARKMNRSQKEKY 277

  Fly   295 IVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEP---- 355
            ::.||:..|..:::    .||      |:|.:....::|               :|::..|
Worm   278 MMKCLQKLSGMELL----SVQ------RSLEEAGYPDIG---------------NLVLRGPLFPD 317

  Fly   356 ---EQQLKSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKL 417
               .:.|:|...  ||:|.|.||.|:.:......|.|.||        |.:.:.....:.| |..
Worm   318 VTSLEMLESPKM--IPMLAGCTKFESDDEDETHFIGKHFG--------LENPIECDEKYRK-DLE 371

  Fly   418 TGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPA 482
            .|...:......|..:        .||..|.|||:....|                       ||
Worm   372 NGIFDRQNHSDKTQAI--------MVPTKLRVDQLRKHGV-----------------------PA 405

  Fly   483 FMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFG-NPMEETRLTSAE 546
            ::|.|.|                        |:...|.|::.|      |.| :|.|:..  :.|
Worm   406 YLYEFTY------------------------PKHAFHTDDLYY------IMGIHPFEKDE--NEE 438

  Fly   547 DL-KVRNNLIDLLVKFANK----DKEEGGKSSIFQSVTGKAT 583
            .| ||..|::...:||...    :..:..:|:.|:....:.|
Worm   439 HLEKVYRNMLINFIKFGEPGMGFEMSDLNESTYFEIYWNETT 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	135/562 (24%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	58/191 (30%)
cest-5.2	NP_501021.3	Abhydrolase	23..498	CDD:389770	135/562 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810