DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5397 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	156/546 - (28%)
Similarity:	233/546 - (42%)	Gaps:	82/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RVEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRPV-YKRLAGDFNATKHGPPCIQPHPQFPQRIIG 125
            :::..|:...|:::|||:.:|:.||||||::.|. .:..:|..:.|.|...|:|......:..:.
  Rat    46 KLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNIDMLDEVGLT 110

  Fly   126 D-----------EDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQYDATPMA-QRGAIVV 178
            |           ||||.||:|||....|.:.|||.|.||.|....|.|:..|.:.:| ....:||
  Rat   111 DMKMILSSIPMSEDCLYLNIYTPAHAHEGSNLPVMVCIHGGALVIGMASMCDGSLLAVNEDLVVV 175

  Fly   179 APQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLS 243
            |.|||||.||....|.:...||....|..||||||...|::|||||.:|...|..:|..|.....
  Rat   176 AIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHV 240

  Fly   244 MSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDII 308
            :||.|:  |..||.:..||.||....:.:........|||::||...:...:|.|||:||..:|
  Rat   241 ISPMSQ--GLFHGAIMESGVALLPDLISETSETVSTTVAKLSGCEATDSETLVRCLRAKSGAEI- 302

  Fly   309 KNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGV 373
                               |..|..|: .|.:..||..||.    .|::.|.|.:|..:|.:.||
  Rat   303 -------------------LVINKVFK-MIPAVVDGEFLPR----HPKELLASEDFHPVPSIIGV 343

  Fly   374 TKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQ 438
            ...|...     ||..|.|:| |.:..|  |...|.:.|| |.....:..||...|   |.....
  Rat   344 NTDEYCC-----TIPMVMGTA-QIIKEL--SRENLQAVLK-DTAAQMMLPPECGDL---LMEEYM 396

  Fly   439 DVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGL 503
            .....||.|.:     :..|...|.||.:||:.........||.:.|.|::..:..|.:
  Rat   397 GNTDDPQTLQI-----QYAEMMGDFLFVIPALQVAHFQRSHAPVYFYEFQHAPSYFKNV------ 450

  Fly   504 PIVSETAHDKPETVGHGDEIGYMFDANDIFGNPM---EETRLTSAEDLKVRNNLIDLLVKFANKD 565
                ...|.|.:   |.||:.::| .:..:|..:   ||.:|.|...:|...|    ..:..|.:
  Rat   451 ----RPPHVKAD---HADEVPFVF-GSFFWGIKVDFTEEEKLLSRRMMKYWAN----FARHGNPN 503

  Fly   566 KEEGGKSSIFQSVTGKATPFIKIDTK 591
            .|    ...:..|......::::||:
  Rat   504 SE----GLPYWPVLDHDEQYLQLDTQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	156/546 (29%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	71/191 (37%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	156/546 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910