Protein Alignment CG5397 and Ces3b

DIOPT Version :9

• Sequence 1: NP_001259865.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 607
• Identity: 159/607 - (26%)
• Similarity: 249/607 - (41%)
• Gaps: 137/607 - (22%)

  Fly     1 MQSQLKRNTLLLLLLSVVILASCKSGGDAHVRVKRIVGGKQSKAPPVDDPVIFARLFDRDARVEG 65
            |::.:...:.:|:.::.::||.          |..:.|.|..: |.||.|:...|     .|..|
Mouse     4 MRTMIPAGSSVLVWVTCLLLAF----------VTTVTGPKVIQ-PEVDTPLGRVR-----GRQVG 52

  Fly    66 FRNPSTGIYSFLGMHYAEPPVGPLRYSRPVYKR-LAGDFNATKHGPPCIQPHPQFPQRIIG---- 125
            .::....:..|||:.:|:.||||||:|.|:..: ..|..:|:.:.|.|:|...:......|
Mouse    53 VKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCLQDVEKMINSRFGLNEK 117

  Fly   126 ------DEDCLLLNVYTPQMPDETTG--LPVFVWIHPGGYRYGSAAQYDATPMAQRG-AIVVAPQ 181
                  .||||.||:|:|  .:.|.|  .||.||||.|....||:...|.:.:|..| .:||..|
Mouse   118 IKIFPISEDCLTLNIYSP--TEITAGDKRPVMVWIHGGSLLVGSSTSQDGSALAAYGDVVVVTVQ 180

  Fly   182 YRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSP 246
            ||||..|.:..|.|...||....|:.||||||...|:.|||:|..|...|:.:|......|.:||
Mouse   181 YRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSP 245

  Fly   247 TSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSKSAEDIIKND 311
            .  |||..|..::.||...:....|.:|....|..|....|.:.:..|:|.||..|..:|:||..
Mouse   246 I--SAGLFHRAISQSGIVTTIMMEDMKPWPEAQNFANSVACGSASPAELVQCLLQKEGKDLIKQK 308

  Fly   312 DKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLKSSNFSGIPLLTGVTKH 376
                               ||... :|.::       |.....||:.|....|..:|.|.|||.|
Mouse   309 -------------------NVNIS-YIVND-------SFFPQRPEKLLADQQFPTVPYLLGVTNH 346

  Fly   377 ETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVW 441
            |             ||..  .|.|| :.|:||....:.|.|  :|::|.|.            :.
Mouse   347 E-------------FGWL--LLKSL-NILDKLEHLSREDLL--EISRPFLA------------IM 381

  Fly   442 KVPQALNVDQVLSKVVESTTD----------VLFNLPAVLTTQVWSRL-----APAFMYSFEYNG 491
            :||..: :..|:.:.:::.:|          :|.::..::.|..:|:.     .|.|:|.|::
Mouse   382 EVPPEI-MPTVIDEYLDNGSDQSATRYAFQELLGDISFIIPTLNFSKYLRDAGCPVFLYEFQH-- 443

  Fly   492 TKSKGINFLKGLPIVSETAHDKPETV--GHGDEIGYMFDANDIFGNPM--EETRLTSAEDLKVRN 552
            |.|....|             ||..|  .|..|..:      :||.|.  :|:.|.:..:.....
Mouse   444 TPSSFAKF-------------KPAWVKADHASENSF------VFGGPFLTDESSLLAFPEATEEE 489

  Fly   553 NLIDLLV-----KFANKDKEEG 569
            ..:.|.:     :||......|
Mouse   490 KQLSLTMMAQWSQFARTGNPNG 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	147/546 (27%)
		Aes	82..>261	CDD:223730	71/192 (37%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	152/565 (27%)
		Aes	75..>245	CDD:223730	61/171 (36%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910