Protein Alignment CG5397 and CEL

DIOPT Version :10

• Sequence 1: NP_608591.1
• Gene: CG5397 / 33313
• FlyBaseID: FBgn0031327
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 158/605 - (26%)
• Similarity: 239/605 - (39%)
• Gaps: 151/605 - (24%)

  Fly    63 VEGFRNPSTGIYS-----FLGMHYAEPPVGPLRYSRPVYKRLAGDFNATK--HGPPCIQPHP--- 117
            |||. |...|:..     |.|:.:|.|                     ||  ..|   ||||
Human    33 VEGV-NKKLGLLGDSVDIFKGIPFAAP---------------------TKALENP---QPHPGWQ 72

  Fly   118 ------QFPQRII----------GDEDCLLLNVYTPQMPDETT-GLPVFVWIHPGGYRYGSA--- 162
                  .|.:|.:          ||||||.||::.||...:.: .|||.:||:.|.:..||.
Human    73 GTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGA 137

  Fly   163 -----AQYDATPMAQRG-AIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYFG 221
                 ..||...:|.|| .|||...||:|.||.:..|.....||..:.|...|:.||...|:.||
Human   138 NFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFG 202

  Fly   222 GNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKING 286
            |:|..:...|..:|.||....::||.::  |.:...::.||.|||.:.:.|.|:...::||:..|
Human   203 GDPNNITLFGESAGGASVSLQTLSPYNK--GLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVG 265

  Fly   287 CPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGL----TGNVGFQPHIESEDDGRAL 347
            ||.|:...:..||:        ..|.:..|  ||.:..:.||    ...|||.|.|    ||..:
Human   266 CPVGDAARMAQCLK--------VTDPRALT--LAYKVPLAGLEYPMLHYVGFVPVI----DGDFI 316

  Fly   348 PSLIVGEPEQQLKSSNFSGIPLLTGVTK---HETANSVTVETIEKVFGSAEQFLGSLSDSLNKLT 409
            |:    :|....  :|.:.|..:.|...   |..| |:.:..|.|  |:.:    ...:...||.
Human   317 PA----DPINLY--ANAADIDYIAGTNNMDGHIFA-SIDMPAINK--GNKK----VTEEDFYKLV 368

  Fly   410 SFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQALNVDQVLSK--VVESTTDVLFNLP---A 469
            |...|.|           ||..  ..|..||:....|.:..|...|  ||:..|||||.:|   |
Human   369 SEFTITK-----------GLRG--AKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIA 420

  Fly   470 VLTTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVG--HGDEIGYMFDANDI 532
            :...:..::.|..:.|.|.:...          :|:.       |:.||  |.|:|.|      :
Human   421 LAQHRANAKSAKTYAYLFSHPSR----------MPVY-------PKWVGADHADDIQY------V 462

  Fly   533 FGNPMEETRLTSAEDLKVRNNLIDLLVKFANKDKEEGGKSSI---FQSVTGKATPFIKIDTKLQT 594
            ||.|.........:|..|...:|.....||.......|.|::   ::..|.:.:.:::|..|:.:
Human   463 FGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGS 527

  Fly   595 S--------NDFRFCELSVL 606
            |        |..|:..|:.|
Human   528 SSMKRSLRTNFLRYWTLTYL 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5397	NP_608591.1	COesterase	48..599	CDD:395084	155/596 (26%)
CEL	NP_001798.3	Heparin-binding	21..121		30/112 (27%)
		COesterase	26..542	CDD:395084	156/598 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
		Mucin-like	584..677	CDD:464997
		Mucin-like	639..731	CDD:464997