DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42329 and CG14219

DIOPT Version :9

Sequence 1:	NP_608590.2	Gene:	CG42329 / 33312	FlyBaseID:	FBgn0259229	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_608322.1	Gene:	CG14219 / 32951	FlyBaseID:	FBgn0031033	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	285/742 - (38%)
Similarity:	421/742 - (56%)	Gaps:	90/742 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IVALIGIMGVGVLTTAQTYSSK----------DLLTWMQSSNFGY------------------QV 38
            :|.|..|:|:|:|..|::.:::          .|||...:....|                  .|
  Fly     1 MVRLAFILGLGLLALAKSVNAQMTNIFAMTNTKLLTEHIAGGDHYSSIFNTRRLSVEFFEHYANV 65

  Fly    39 LQQALNDNQSS---SAAEASCLAEVRLLLTGAEAKSLPALRVFDAWGKFPQGLLYGHFMDMGNYE 100
            ..:.|..|.:|   |..:..|||::.||.....:....||::.|:||..|.|:|.|::.::||::
  Fly    66 TLEDLTANSNSRIPSLQDLECLADLALLSKDLSSFKFWALKMIDSWGLLPSGMLAGNWWNLGNFD 130

  Fly   101 SCLSLDLSKSLGNVMTINAGAKYCLSRM-QFESLLMEAAGADALTLSIGTCIPSSCSAAQLSRWM 164
            .|:::|.:.:..:    :...|||:::: ...|||      ..|.|....|.|::||||.    |
  Fly   131 ECIAIDHAVTSSH----SIKGKYCITKLTPAPSLL------PILALKSAVCFPATCSAAN----M 181

  Fly   165 SGHLKDMFGQNST-----EATLVQEKDCSLAHRDPMNGLDWLAVSILILLCIVVLLATILDY-SC 223
            ...|:.:|.:..|     :..:|.|:.|..|.:.|.:||....:.|:.:|..:|.:.||.|| .|
  Fly   182 DTMLRRLFQKLLTVEIDADVQIVAEETCQTAVKKPYDGLAIFTIVIVSILGAIVGVCTIFDYFFC 246

  Fly   224 VSNK----LLSSFSLRKNVPQLLKTSNT-PSPRVIPCLNGIRCLTIIWIILGHGYMYLLLAPTIN 283
            ...|    ::.:||.|.|...|.:..:| .:|.||.||:|||||:.||::.||.||.|..:|.||
  Fly   247 KDEKTIHPVVEAFSARANSRALFRIVDTKANPNVIDCLHGIRCLSFIWVVYGHDYMVLATSPNIN 311

  Fly   284 AYDIVAWAQMPFSMILQSGTTSVDTFFLLSGLLLVLSALREMDRSKGRLHVPLMYLHRLVRLTPV 348
            ...::.|....:|:.::....:||:||.|||||||:.|||.|||:||:|::|||||||.:||||:
  Fly   312 MGYLLTWINSFYSLFVKHAVYAVDSFFFLSGLLLVVIALRSMDRTKGKLNIPLMYLHRYLRLTPI 376

  Fly   349 LALAVLIFMTLFPRLDSGPLWNQFT-SSSELCSDTWWATLLYVQNYAAPGRMCLGHSWYLAVDMQ 412
            ||:|:|.:|.:.|..:||||....: .....|..||:.|||||||||... :||.||||||||||
  Fly   377 LAIAILFYMKILPLWESGPLKGSISFDDYSACESTWYWTLLYVQNYATDS-LCLSHSWYLAVDMQ 440

  Fly   413 LYIISPLLLIALYKWGKKAIAGIVLLILLLSGCVFGIVMLRDLKVFDRYGNLGGDSTEMRLIYYT 477
            |||.:|.|||.||||||||.|||.:|:|||:||:|.|:::.||.:     ..||||  ||.:||.
  Fly   441 LYIFAPFLLICLYKWGKKAAAGIFVLMLLLAGCLFSIMVINDLSL-----GSGGDS--MRKLYYA 498

  Fly   478 THARATPWLIGLLFGYFLHHQNVRKTRLPKWLALVLWILSLSMLATVIFAVYPYTQSGAGDISAM 542
            |..||:|:|||:|||||||....:..:|.:...|:.|:::||::|:.:|::|     |...:..:
  Fly   499 TQTRASPYLIGILFGYFLHTNRGKDFKLNRLAVLLGWLIALSLIASCLFSIY-----GQNTLPIV 558

  Fly   543 AGAFYLCCSRIAWPLALCWIIWACQNGLAPIVNEFLSWSFWQPLSKLSYCLYIWHLLVETVHIAR 607
            ..|||:..:||||||.|||:::||.:|...:.|..||...|||||:|||..||:|:.:|:::...
  Fly   559 EEAFYVSLTRIAWPLGLCWVVFACMHGYGGLANSLLSSPLWQPLSRLSYSAYIFHMFIESLNGGI 623

  Fly   608 IKTSLHFSDYDAILRFWSDFGITLFVSMFMHLCVEVPLGRLEMELL---------------KRCQ 657
            ..||.:||||..:||||:|||.|:..|..||:.:|.|...||..||               :..:
  Fly   624 THTSTYFSDYQVMLRFWTDFGFTILFSYLMHILIEAPFAGLESLLLPAKRPNAKPAAVVEPRMSE 688

  Fly   658 KKEDSPESPRVDP----STEPTEVIPA 680
            .|....|||...|    ||.|.|||.|
  Fly   689 VKASVEESPVGKPAEAISTIPDEVIQA 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42329	NP_608590.2	NRF	71..179	CDD:214781	31/113 (27%)
		OafA	253..648	CDD:224748	193/395 (49%)
		Acyl_transf_3	253..639	CDD:280013	190/386 (49%)
CG14219	NP_608322.1	NRF	101..211	CDD:214781	34/123 (28%)
		Acyl_transf_3	281..654	CDD:280013	189/385 (49%)
		OafA	326..683	CDD:224748	177/369 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458070
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	12	11.800