DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42329 and CG14204

DIOPT Version :9

Sequence 1:	NP_608590.2	Gene:	CG42329 / 33312	FlyBaseID:	FBgn0259229	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	272/708 - (38%)
Similarity:	390/708 - (55%)	Gaps:	49/708 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IVALIGIMGVGVLTTA-QTYSSKDLLTWMQ---SSNFGYQVL-------QQALNDNQSSSAAEA- 54
            ::|::..||:.::..| .|..|.:  .|.|   ||...|:.|       .:...:.::.|.|:.
  Fly     4 LLAILLAMGMAMVQGALPTQLSNN--QWTQHDVSSMADYERLLDLRSLAMEFYREFRNISTADVH 66

  Fly    55 -----------SCLAEVRLLLTGAEAKSLPALRVFDAWGKFPQGLLYGHFMDMGNYESCLSLDLS 108
                       .|||::...::...|....||::.||||..|.|.|.|:.:|||||..||
  Fly    67 LLGERIGSQDLQCLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNYRECL----- 126

  Fly   109 KSLGNVMTINAG--AKYCLSRMQFESLLMEAAGADALT-LSIGTCIPSSCSAAQLSRWMSGHLKD 170
             |.|.::|.:..  .|||...:.....|...:...|:| :....|:||||||..:..::...||.
  Fly   127 -SEGGMLTSSQDIQGKYCFMELPVAKWLGFTSELLAVTNIRTAVCLPSSCSAGTMELFLKQLLKR 190

  Fly   171 MFG-QNSTEATLVQEKDCSLAHRDPMNGLDWLAVSILILLCIVVLLATILDY-SCVSNKLL---- 229
            :.| .:.|....:.|..|.:..:.|.:||....|.:|.:..:.|:|.|:.|| .|...:.|
  Fly   191 LLGVSDPTNLFSISETSCRIKEKAPWDGLTIFTVVLLSVFGVTVILCTLYDYFLCPEQEKLPRPI 255

  Fly   230 SSFSLRKNVPQLLK-TSNTPSPRVIPCLNGIRCLTIIWIILGHGYMYLLLAPTINAYDIVAWAQM 293
            .:||.|.....|.. ..||.:|.||.||||:||:::||:||.|.|:..:..|.||..|.:.||..
  Fly   256 GAFSARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSHEYIINMKGPAINPADNLRWATQ 320

  Fly   294 PFSMILQSGTTSVDTFFLLSGLLLVLSALREMDRSKGRLHVPLMYLHRLVRLTPVLALAVLIFMT 358
            .||..:..||.||||||.:||||||...||.::::||:|:||||||||.:||||::|:|:|.|..
  Fly   321 LFSSFILYGTLSVDTFFFISGLLLVSIGLRSIEKNKGKLNVPLMYLHRYLRLTPIVAVAILAFYK 385

  Fly   359 LFPRLDSGPLWNQ---FTSSSELCSDTWWATLLYVQNYAAPGRMCLGHSWYLAVDMQLYIISPLL 420
            :.|.:..||:::.   |..|.  |..||:.|||||||||. ..:|:.|:|||||||||||:||:|
  Fly   386 MIPLIADGPMYDDIGFFDYSG--CKMTWYWTLLYVQNYAT-SDVCVPHTWYLAVDMQLYILSPIL 447

  Fly   421 LIALYKWGKKAIAGIVLLILLLSGCVFGIVMLRDLKVFDRYGNLGGDSTEMRLIYYTTHARATPW 485
            |||||||||||..||:::.||||.|:|..:|:.|..|..:.|...  ....|.||..||..|.||
  Fly   448 LIALYKWGKKAAGGILVVTLLLSACLFATIMVNDFPVMFKNGIQA--QVVQRKIYTATHTHAAPW 510

  Fly   486 LIGLLFGYFLHHQNVRKTRLPKWLALVLWILSLSMLATVIFAVYPYTQSGAGDISAMAGAFYLCC 550
            |:|.:|||.||....|:.:|........|:|.|:.|.|.|||:|||::......|.:.||.|...
  Fly   511 LVGTMFGYLLHLMRGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSKLLGKSPSVLQGALYYTL 575

  Fly   551 SRIAWPLALCWIIWACQNGLAPIVNEFLSWSFWQPLSKLSYCLYIWHLLVETVHIARIKTSLHFS 615
            .||||||.|||:::||..|...:.|.|||...|||||||||..||||:.|..|....::|:.:||
  Fly   576 VRIAWPLGLCWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYIWHIFVVEVANRSVQTNTYFS 640

  Fly   616 DYDAILRFWSDFGITLFVSMFMHLCVEVPLGRLEMELLKRCQKKEDSPESPRVDPSTE 673
            :|..:|.|||.||.||.:|..:::.:|.||..||..:....:....:.:...::..||
  Fly   641 NYQVMLNFWSTFGFTLLMSYVLYVLIEAPLEALERIMFPNRRSPPAAKDQLHIESRTE 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42329	NP_608590.2	NRF	71..179	CDD:214781	37/111 (33%)
		OafA	253..648	CDD:224748	191/397 (48%)
		Acyl_transf_3	253..639	CDD:280013	188/388 (48%)
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	38/120 (32%)
		Acyl_transf_3	280..664	CDD:280013	188/388 (48%)
		OafA	283..687	CDD:224748	191/408 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458068
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	12	11.800