DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42329 and nrf-6

DIOPT Version :9

Sequence 1:	NP_608590.2	Gene:	CG42329 / 33312	FlyBaseID:	FBgn0259229	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_495680.1	Gene:	nrf-6 / 174287	WormBaseID:	WBGene00003813	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	695	Identity:	172/695 - (24%)
Similarity:	317/695 - (45%)	Gaps:	121/695 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VFDAWGKFPQGLLYGHFMDMGNYESCLSLDLSKS--------------------------LGNVM 115
            ||||.||.|.|::.|:.:.:|::.:|..:|:.|:                          .||:|
Worm   157 VFDAMGKVPAGIMSGNNLWVGSWSTCRKIDVVKNAQGQKWKGQYCLATIDAYERDNPLVYFGNMM 221

  Fly   116 TINAGAKYCLSRMQFESLLMEAAGADAL------TLSIGTCIPSSCSAAQLSRWMSGHLKDMFGQ 174
            : ....|:|..:      .::....|..      .|..|.|:|::|:...:.:.:|..::...|.
Worm   222 S-GPPDKHCYDK------TVKNVTDDGFCFALFPVLKFGVCMPNTCTNHDVKQMLSFAIRATEGA 279

  Fly   175 NSTEATLVQEKDC-SLAHRDPM--NGLDWLAVSILILLCIVVLLATILDYSCVSN---------- 226
            ..|::....:.:| :.::.|.|  |||...|:.:||...::|...|:.|...||.
Worm   280 VGTKSVCNVDVECRAESYSDAMSENGLAMFALYLLIATVVLVTFGTLYDLFIVSKAPQDEKNSSA 344

  Fly   227 ------KLLSSFSLRKNVPQLLKTSNTPSPRVIPCLNGIRCLTIIWIILGHGYMYL-------LL 278
                  |.:.:||:..|..::|::..  :.|.|..|:|:|.|::.||||||.|.|:       .|
Worm   345 FNHPFIKFILAFSMYTNGSEILQSKK--NDREINSLHGVRFLSMCWIILGHTYYYIGTSLTTDNL 407

  Fly   279 APTINAYDIVAWAQMPFSMILQSGTTSVDTFFLLSGLLLVLSALREMDRS----KGRLHV----- 334
            .||     ::.:.:...:.|:.....:||:||.|||:|...|..::..::    ..:|..
Worm   408 VPT-----LINFPKQFHTQIIVQAPLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLSAFNWQT 467

  Fly   335 -PLMYLHRLVRLTPVLALAVLIFMTLFPRLDSGPLWNQFTSSSELCSDTWWATLLYVQNYAAPGR 398
             |:.|..|.:|:||...:.:|..:|||..:.:||.|.......  ||..||..|:|:.|:....:
Worm   468 WPMYYYKRYIRITPTYIIVMLFDVTLFTYISNGPFWRPIERQG--CSIAWWTNLIYLNNFLLQDQ 530

  Fly   399 -MCLGHSWYLAVDMQLYI-ISPLLLIALYKWGKKAIAGIVLLILLLSGC-------VFGI----V 450
             .|:|.:||||.|||.:| :.|||:|...|||.|...|:...::.||..       ::|.    :
Worm   531 ECCMGWTWYLANDMQFHIFLMPLLVIVFLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPI 595

  Fly   451 MLRDLKVFDRYGNLGGDSTEMRLIYYTTHARATPWLIGLLFGYFLHHQNVR-----KTRLPKWLA 510
            :...|::..:..:...|      :|...:.|.||:::|::..|.|:....|     |.:|.:...
Worm   596 LTAKLQIVYQLNDYWND------VYVRPYIRCTPFIVGIVVAYLLNAWTTREQKDLKIKLERRTV 654

  Fly   511 LVLWILSLSMLATVIFAVYPYTQSGAGDISAMAGAFYLCCSRIAWPLALCWIIWACQNGLAPIVN 575
            ::.|..|..:....:|.:|.:.::  ||||......|......|:.|||.|:::||..|....|:
Worm   655 IICWCTSTVLGLYSVFGLYWFAKT--GDISKPWEILYTIFGTPAYALALGWVVFACTTGNGGPVD 717

  Fly   576 EFLSWSFWQPLSKLSYCLYIWH-LLVETVHIARIKTSLHFSDYDAILRFWSDFGITLF-VSMFMH 638
            ..|||..:.||||:::|.|:.| ::::..:::| ....||:.:..::|:..:.....: ::.|..
Worm   718 TILSWRLFVPLSKITFCAYLLHPIMLQIYNLSR-PQPFHFTTFIQMIRYTVEAVFASYTIAFFFS 781

  Fly   639 LCVEVPLGRLEMELLKRCQKKEDSPESPRVDPSTEPTEVIPATSI 683
            |..|.||.::: |:|...:|..:....       ..||::|...|
Worm   782 LAFEKPLNKID-EMLFNSKKMMNGENG-------NTTEMVPLNKI 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42329	NP_608590.2	NRF	71..179	CDD:214781	27/133 (20%)
		OafA	253..648	CDD:224748	118/431 (27%)
		Acyl_transf_3	253..639	CDD:280013	114/422 (27%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	27/137 (20%)
		OafA	375..790	CDD:224748	118/430 (27%)
		Acyl_transf_3	375..777	CDD:280013	113/417 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm14368
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650