DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5001 and DNAJA3

DIOPT Version :9

Sequence 1:	NP_001245832.1	Gene:	CG5001 / 33308	FlyBaseID:	FBgn0031322	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_005138.3	Gene:	DNAJA3 / 9093	HGNCID:	11808	Length:	480	Species:	Homo sapiens

Alignment Length:	395	Identity:	105/395 - (26%)
Similarity:	161/395 - (40%)	Gaps:	113/395 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KDYYKILGLPKTATDDEIKKAYRKLALRYHPDKNK-AANAEDKFKEVAEAYEVLSDKSKREVYDK 66
            :|||:|||:|:.|:..||||||.:||.:||||.|| ...|::||.::|||||||||:.||:.||.
Human    92 EDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDA 156

  Fly    67 YGEDGLKSGGTRN------GGPSSNSFTYQFHGDPRATFAQFFG--NSNPFASF---FDMGDNLF 120
            ||..|...|.:.:      |||:.         ||...|.:.||  :|:.|..|   ||.....|
Human   157 YGSAGFDPGASGSQHSYWKGGPTV---------DPEELFRKIFGEFSSSSFGDFQTVFDQPQEYF 212

  Fly   121 DKKVFDLDTEPDFFSSPFGGIGSRHGL----------GSGFRPSFRSHSFNVHTPFKKEQKQDPP 175
            .:..|:...:         |:.....:          |.|..|..:
Human   213 MELTFNQAAK---------GVNKEFTVNIMDTCERCNGKGNEPGTK------------------- 249

  Fly   176 VEHDLYV---TLEEIYHGCVKKMKISRR------------IVQADGSSRKEEKFLAISIKPGWKS 225
            |:|..|.   .:|.|..|........||            :|.......|::|.:.|.:..|.:.
Human   250 VQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVED 314

  Fly   226 GTKVTFQKEGDQAP-GKIPADIVFIIRDKPHAMFKREGSDLRYTARLTLKQALCG---------- 279
            |..|       :.| ||....|.|.::..|  :|:|:|:|:.....:::.|||.|
Human   315 GQTV-------RMPVGKREIFITFRVQKSP--VFRRDGADIHSDLFISIAQALLGGTARAQGLYE 370

  Fly   280 ---VVFQVPTMSGDKLRISTMQEIIKPNTVKRIQGYGLPFPKDTTRKGDLLVAFDIQFPEKLTAA 341
               |.....|.:..|:|:.       ...:.||..||.         ||..:...|:.|::||:.
Human   371 TINVTIPPGTQTDQKIRMG-------GKGIPRINSYGY---------GDHYIHIKIRVPKRLTSR 419

  Fly   342 QKEVL 346
            |:.::
Human   420 QQSLI 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5001	NP_001245832.1	DnaJ	1..347	CDD:223560	105/395 (27%)
		DnaJ	4..65	CDD:278647	36/61 (59%)
		DnaJ_C	174..338	CDD:199909	41/192 (21%)
DNAJA3	NP_005138.3	DnaJ	90..480	CDD:223560	105/395 (27%)
		DnaJ	93..155	CDD:278647	36/61 (59%)
		DnaJ_C	207..416	CDD:199909	47/261 (18%)
		DnaJ_zf	236..296	CDD:199908	12/78 (15%)
		CXXCXGXG motif	236..243		1/6 (17%)
		CXXCXGXG motif	253..260		1/6 (17%)
		CXXCXGXG motif	275..282		2/6 (33%)
		CXXCXGXG motif	289..296		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910