DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5001 and DNAJB14

DIOPT Version :9

Sequence 1:	NP_001245832.1	Gene:	CG5001 / 33308	FlyBaseID:	FBgn0031322	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_001026893.1	Gene:	DNAJB14 / 79982	HGNCID:	25881	Length:	379	Species:	Homo sapiens

Alignment Length:	266	Identity:	78/266 - (29%)
Similarity:	110/266 - (41%)	Gaps:	69/266 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KDYYKILGLPKTATDDEIKKAYRKLALRYHPDKNKAANAEDKFKEVAEAYEVLSDKSKREVYDKY 67
            |:||::||:.|.|.|:::|||||||||::|||||.|..|.|.||::..||.|||:..||:.||..
Human   107 KNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLT 171

  Fly    68 GEDGLKSGGTRNGGPSSNSFTYQFHG------DPRATFAQFFGNSNPFASFF------------- 113
            |.:........||       .:.||.      .|...|..|||...|..|..
Human   172 GNEEQACNHQNNG-------RFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAGYSQQH 229

  Fly   114 -----------DMGDNLFDKKVFDLDTEPD------------FFSSPFGGIGSRHGLGSGFRPSF 155
                       :.||..|  .|| :...|.            ..|:|...:..|.|.|...:...
Human   230 QHRHSGHEREEERGDGGF--SVF-IQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGTGQTIKMQT 291

  Fly   156 RSHS--FNVHTPFKKE------QKQDPPVEHDLYVTLEEIYHGCVKK------MKISRRIVQADG 206
            .:..  :.|:..||.|      ||.:..||.| |||  .|.:.|.|:      |:.:.::.:.|.
Human   292 ENLGVVYYVNKDFKNEYKGMLLQKVEKSVEED-YVT--NIRNNCWKERQQKTDMQYAAKVYRDDR 353

  Fly   207 SSRKEE 212
            ..||.:
Human   354 LRRKAD 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5001	NP_001245832.1	DnaJ	1..347	CDD:223560	78/266 (29%)
		DnaJ	4..65	CDD:278647	33/60 (55%)
		DnaJ_C	174..338	CDD:199909	13/45 (29%)
DNAJB14	NP_001026893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..94
		DnaJ	107..>214	CDD:223560	47/113 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..241		0/21 (0%)
		DUF1977	271..371	CDD:370429	24/92 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740