DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5001 and DNAJB2

DIOPT Version :9

Sequence 1:	NP_001245832.1	Gene:	CG5001 / 33308	FlyBaseID:	FBgn0031322	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_006727.2	Gene:	DNAJB2 / 3300	HGNCID:	5228	Length:	324	Species:	Homo sapiens

Alignment Length:	289	Identity:	99/289 - (34%)
Similarity:	129/289 - (44%)	Gaps:	94/289 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YYKILGLPKTATDDEIKKAYRKLALRYHPDKN--KAANAEDKFKEVAEAYEVLSDKSKREVYDKY 67
            ||:||.:|::|:.|:||||||:.||::|||||  ....||.|||||||||||||||.|||:||:|
Human     4 YYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRY 68

  Fly    68 GEDGLKSGGT-------RNGGPSSNSFTYQFHGDPRATFAQFFGNSNPFASFFDMGDNLFDKKVF 125
            |.:||...||       .:|||   .||:.|. .|...|.:|||:.:|||..||
Human    69 GREGLTGTGTGPSRAEAGSGGP---GFTFTFR-SPEEVFREFFGSGDPFAELFD----------- 118

  Fly   126 DLDTEPDFFSSPFGGI---GSRHGLGSG----FRPSFRSH------------------SFNVHTP 165
            ||        .||..:   ||||   ||    |..||..|                  |.:..|.
Human   119 DL--------GPFSELQNRGSRH---SGPFFTFSSSFPGHSDFSSSSFSFSPGAGAFRSVSTSTT 172

  Fly   166 FKKEQK-----------QDPPVEHD---LYVTLEEIYHGCVKKMKISRRIVQADGSSRKEEKFLA 216
            |.:.::           :...||.|   ..||:..:.......:::|||..|...:||
Human   173 FVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVTSR------- 230

  Fly   217 ISIKPGWKSGTKVTFQKEGDQAPGKIPAD 245
                   ..||:|      .|.|...|.|
Human   231 -------SGGTQV------QQTPASCPLD 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5001	NP_001245832.1	DnaJ	1..347	CDD:223560	99/289 (34%)
		DnaJ	4..65	CDD:278647	40/61 (66%)
		DnaJ_C	174..338	CDD:199909	18/75 (24%)
DNAJB2	NP_006727.2	DnaJ	3..>110	CDD:223560	59/109 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..90		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..324		13/49 (27%)
		CAAX motif. /evidence=ECO:0000269\|PubMed:12754272	321..324
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740