Protein Alignment Tgt and QTRT1

DIOPT Version :10

• Sequence 1: NP_608585.1
• Gene: Tgt / 33307
• FlyBaseID: FBgn0031321
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_112486.1
• Gene: QTRT1 / 81890
• HGNCID: 23797
• Length: 403
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 230/390 - (58%)
• Similarity: 293/390 - (75%)
• Gaps: 4/390 - (1%)

  Fly     8 PLTYKVVAECSVSKARAGLMTLRHSEVNTPVFMPVGTQGTLKGIVPDQLIELNCQILLGNTYHLG 72
            |...::|||||.|:||||.:.|.|..|.||||||||||.|:|||..:||..|.|:|.||||||||
Human    14 PRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYHLG 78

  Fly    73 LRPGIETLKKAGGLHKFMGWPRAILTDSGGFQMVSLLQLAEIDEHGVNFRSPFDNSQCMLTPEHS 137
            ||||.|.::||.|||.||.||..:||||||||||||:.|:|:.|.||.||||:|.::.:|:||.|
Human    79 LRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPEKS 143

  Fly   138 IEIQNAIGGDIMMQLDDVVKTTTTGPRVEEAMERTIRWVDRCIEAHARDDDQSLFPIVQGGLDVP 202
            ::||||:|.||:|||||||.:|.|||||||||.|:|||:||||.||.|.|.|:||.|:|||||..
Human   144 VQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDAD 208

  Fly   203 LRQRCVSALMERQVRGFAVGGLSGGESKHDFWRMVDVCTGYLPKDKPRYLMGVGFAADLVVCVAL 267
            ||..|:..:.:|.|.|||:|||||||||..|||||.:.|..|||||||||||||:|.||||||||
Human   209 LRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGYATDLVVCVAL 273

  Fly   268 GIDMFDCVFPTRTARFGCALVDSGQLNLKQPKYKLDMEPIDKDCDCSTCRRYTRSYLHHIATNES 332
            |.|||||||||||||||.|||.:|.|.|::..::.|..|||.:|.|.||::::|::||.:..:::
Human   274 GCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDN 338

  Fly   333 VSS-SLLSIHNVAYQLRLMRSMREAIQRDEFPQFVADFMARHFKAEPV--PAWIREALSAVNIQL 394
            .:: ..|::||:||||:||.::|.:|....||.||.|||...: .:|.  |.|..:||::|.|.|
Human   339 TAALHHLTVHNIAYQLQLMSAVRTSIVEKRFPDFVRDFMGAMY-GDPTLCPTWATDALASVGITL 402

  Fly   395  394
            Human   403  402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tgt	NP_608585.1	TGT	20..375	CDD:460299	216/355 (61%)
QTRT1	NP_112486.1	TGT	26..381	CDD:460299	216/354 (61%)
		RNA binding. /evidence=ECO:0000255|HAMAP-Rule:MF_03218	260..266		4/5 (80%)
		RNA binding, important for wobble base 34 recognition. /evidence=ECO:0000255|HAMAP-Rule:MF_03218	284..288		3/3 (100%)