DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4896 and Rbm5

DIOPT Version :9

Sequence 1:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001346454.1	Gene:	Rbm5 / 83486	MGIID:	1933204	Length:	815	Species:	Mus musculus

Alignment Length:	899	Identity:	282/899 - (31%)
Similarity:	430/899 - (47%)	Gaps:	131/899 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SRQNLDQRHGE--DKYDRRHADSQGRRDHDSNYDKSGQDMDKDRDHRWKNYDRVSRERNHDDFDR 146
            ||.....|:|.  |:.||...:|:.|| .||:|.:|..|...||...:::||...|||...:.||
Mouse     8 SRTERSGRYGSIIDRDDRDERESRSRR-RDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDR 71

  Fly   147 GSERSSRSNDQRQFNNNGNSNSSSSYRDREKERDRDRRCSSDEDSDMASEFRQRGAYNSGSSVEP 211
            ..:               ..:|...|.:.:...|     .|||...
Mouse    72 SED---------------GYHSDGDYGEHDYRHD-----ISDERES------------------- 97

  Fly   212 LNNIILFGLKKHVTEADIMGELIKVD-LEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWMELT 275
             ..|:|.||...:||:||...:...: .:|..:|:| |::||.||.||||||..:::||.|||..
Mouse    98 -KTIMLRGLPITITESDIREMMESFEGPQPADVRLM-KRKTGVSRGFAFVEFYHLQDATSWMEAN 160

  Fly   276 QGVLQLGDHRVTMQYSHTR--ISDWTCIKCGASNFKRRFQCYMCNASRAESENALYGAGEGVDEI 338
            |..|.:....:.|.||:.|  ..||.|.||..:||::|.:|:.|.|.:.:||..:   ..|..|.
Mouse   161 QKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEV---PPGTTES 222

  Fly   339 SQIL---TKKIMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSRDALTNASRGICYLNFDTL 400
            :|.:   ...|:||.:...|..:.::|||.   |..:..|:.:.:.:|..|..:||..::...:.
Mouse   223 AQSVDYYCDTIILRNIAPHTVVDSIMTALS---PYASLAVNNIRLIKDKQTQQNRGFAFVQLSSA 284

  Fly   401 IDSMNVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMMPAEGNFFRAGETAMSPSAITAAYTLAD 465
            :|:..:...|.:|.|||.:|.||:.|.:...:....::| :||  |....:::.:||.||...:.
Mouse   285 MDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLP-DGN--RVSAFSVASTAIAAAQWSST 346

  Fly   466 VPRLAEYSASVYA------SNPLEHANYVQYYTDYYTTEISKNCRDRQVTEANSGAAVALSAIQR 524
            ..:..|..:..|:      ....::..|.|.|..:|..:......|...|...:....:.:.:.:
Mouse   347 QSQSGEGGSVDYSYMQPGQDGYTQYTQYSQDYQQFYQQQAGGLESDTSATSGTTVTTTSAAVVSQ 411

  Fly   525 KQRKVSQMETTV-SVTEAKVAFLARGESAPKGN-----DGKKYDTPDVSKYQYDETSGYYYDHVT 583
            ..:..:|..... |.||......:....||..:     .|.||..||.|.|||||:||||||..|
Mouse   412 SPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTT 476

  Fly   584 GLYYDAHSQYYYNNETGAYLYWDQKRSTYVLATPASTQAALKEVLADAEKKEEEAKKAKEKEKEK 648
            |||||.:||||||:.|..|||||.::.|||   ||          |:|...::....:.::.|||
Mouse   477 GLYYDPNSQYYYNSLTQQYLYWDGEKETYV---PA----------AEASSNQQTGLPSTKEGKEK 528

  Fly   649 EEAGGKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILSDTEAATTSRASQGAYADVGFS 713
            :|   || |.|.|::|.||||:|||.||::|: ....:.||:.|..|    ....:.|.||.||:
Mouse   529 KE---KP-KSKTAQQIAKDMERWAKSLNKQKE-NFKNSFQPVNSLRE----EERRESAAADAGFA 584

  Fly   714 ILEKK-ELGKLNDYVPE------AGPPAISKLVGAYGGPSDSEDDNSANQKALEASVGTKRAISD 771
            :.||| .|.:....:||      ...|....||.||.|.||:|::.            .:|..|:
Mouse   585 LFEKKGALAERQQLLPELVRNGDEENPLKRGLVAAYSGDSDNEEEL------------VERLESE 637

  Fly   772 ESDYVDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLDKLKRN-------PAVEAGTDEGLSY 829
            |....|::|:.||||.|.|.:.|.|.:|.::|:|||:|:|..:|:       .|:|....| :.|
Mouse   638 EEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELRERE-MKY 701

  Fly   830 RDRAKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKDSFGATAAMPISSTNVGSRLMQKMGWS 894
            ||||.|||.|||..:||.|.| :::|:......:...||.        |..:|:|::::|.|||.
Mouse   702 RDRAAERREKYGIPEPPEPKR-KKQFDAGTVNYEQPTKDG--------IDHSNIGNKMLQAMGWR 757

  Fly   895 EGQGLGKKNQGRTEIIEADGRSNNVGLG-NNTGHMAPGND-YKSYIKKMMKQRY 946
            ||.|||:|.||.|..|||..|....||| ..:.:...|.| ||..::|.|..|:
Mouse   758 EGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARF 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	22/68 (32%)
		RRM1_RBM5_like	211..291	CDD:241005	30/80 (38%)
		ZnF_RBZ	296..320	CDD:197784	10/23 (43%)
		RanBP2-type Zn finger	298..317	CDD:275376	8/18 (44%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	23/85 (27%)
		OCRE_RBM5_like	562..617	CDD:293881	35/54 (65%)
		OCRE repeat 1	567..574	CDD:293881	5/6 (83%)
		OCRE repeat 2	575..582	CDD:293881	6/6 (100%)
		OCRE repeat 3	583..590	CDD:293881	6/6 (100%)
		OCRE repeat 4	591..598	CDD:293881	6/6 (100%)
		OCRE repeat 5	600..607	CDD:293881	4/6 (67%)
		G-patch	882..922	CDD:279867	20/39 (51%)
Rbm5	NP_001346454.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		27/105 (26%)
		RRM1_RBM5	93..179	CDD:241196	34/106 (32%)
		zf-RanBP	183..210	CDD:366216	11/26 (42%)
		RanBP2-type Zn finger	185..204	CDD:275375	8/18 (44%)
		RRM2_RBM5	229..314	CDD:241199	23/87 (26%)
		Required for interaction with U2AF2. /evidence=ECO:0000250	321..809		179/534 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..468		19/82 (23%)
		Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000250	452..535		48/99 (48%)
		OCRE_RBM5	455..510	CDD:293887	37/67 (55%)
		OCRE repeat 1	460..467	CDD:293887	5/6 (83%)
		OCRE repeat 2	468..475	CDD:293887	6/6 (100%)
		OCRE repeat 3	476..483	CDD:293887	6/6 (100%)
		OCRE repeat 4	484..491	CDD:293887	6/6 (100%)
		OCRE repeat 5	493..500	CDD:293887	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		12/44 (27%)
		G-patch	743..785	CDD:366717	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843024
Domainoid	1	1.000	124	1.000	Domainoid score	I5489
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2109
Isobase	1	0.950	-	0	Normalized mean entropy	S4453
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm8864
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1777
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.890