DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4896 and GPATCH2

DIOPT Version :9

Sequence 1:NP_608583.5 Gene:CG4896 / 33305 FlyBaseID:FBgn0031319 Length:949 Species:Drosophila melanogaster
Sequence 2:XP_011507991.1 Gene:GPATCH2 / 55105 HGNCID:25499 Length:551 Species:Homo sapiens


Alignment Length:468 Identity:96/468 - (20%)
Similarity:142/468 - (30%) Gaps:173/468 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   494 YYTTEISKN-CRDRQVTEANSG-----AAVALSAIQRKQRKVSQMETTVSVTEAKVAFLARGESA 552
            |...|.:|| .:.|::.....|     ..|.|.:.:..|....:||    ..|.||:.....|| 
Human   199 YQYQEFTKNKVKKRKLKIIRQGPKIQDEGVVLESEETNQTNKDKME----CEEQKVSDELMSES- 258

  Fly   553 PKGNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYYDAHSQYYYNNE-------TGAYLYWDQKRS 610
                |.....:.|...:..||  |...|       |..|.::|..|       ||...:|     
Human   259 ----DSSSLSSTDAGLFTNDE--GRQGD-------DEQSDWFYEKESGGACGITGVVPWW----- 305

  Fly   611 TYVLATPASTQAALKEVLADAEKKEEEAKKAKEKEKEKEEAGGKPDKVKVAKKIVKDMEKWAKQL 675
                                            |||...|.....||.|                 
Human   306 --------------------------------EKEDPTELDKNVPDPV----------------- 321

  Fly   676 NQKKDYTAVATPQ-PILSDTE----AATTSRASQGAYADVGFSILEKKELGKLNDYVPEAGPPAI 735
                 :.::.|.. |::|...    .|..||....:..::      ||..|.....||..||   
Human   322 -----FESILTGSFPLMSHPSRRGFQARLSRLHGMSSKNI------KKSGGTPTSMVPIPGP--- 372

  Fly   736 SKLVGAYGGPSDSEDDNSANQKALEASVGTKRAI--SDESDYVDFQKLTCLLCMRAFQSLDILQK 798
                                       ||.||.:  |.:|.:.|                     
Human   373 ---------------------------VGNKRMVHFSPDSHHHD--------------------- 389

  Fly   799 HLKMSNLHKE-NLDKLKRNPAVEAGTDEGLSYRDRAKERRLKYG-----------ESDP-PPPNR 850
            |........| :..:|.|:...|.|..:..|.|..:::..:..|           ::.| |.|..
Human   390 HWFSPGARTEHDQHQLLRDNRAERGHKKNCSVRTASRQTSMHLGSLCTGDIKRRRKAAPLPGPTT 454

  Fly   851 ----SRERFEQEIKTL--QSRQKDSFGATAAMPISSTNVGSRLMQKMGWSEGQGLGKKNQGRTEI 909
                |....|..:.:|  |...|..|....|.||...|:|:|::|.|||:.|.|||:..:|.:|.
Human   455 AGTCSHILDETHVISLAIQIFHKAGFVGENAQPILENNIGNRMLQNMGWTPGSGLGRDGKGISEP 519

  Fly   910 IEADGRSNNVGLG 922
            |:|..|...:|||
Human   520 IQAMQRPKGLGLG 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4896NP_608583.5 DUF1777 91..>158 CDD:285811
RRM1_RBM5_like 211..291 CDD:241005
ZnF_RBZ 296..320 CDD:197784
RanBP2-type Zn finger 298..317 CDD:275376
RRM1_RRM2_RBM5_like 343..429 CDD:240759
OCRE_RBM5_like 562..617 CDD:293881 12/61 (20%)
OCRE repeat 1 567..574 CDD:293881 1/6 (17%)
OCRE repeat 2 575..582 CDD:293881 2/6 (33%)
OCRE repeat 3 583..590 CDD:293881 1/6 (17%)
OCRE repeat 4 591..598 CDD:293881 2/6 (33%)
OCRE repeat 5 600..607 CDD:293881 2/6 (33%)
G-patch 882..922 CDD:279867 17/39 (44%)
GPATCH2XP_011507991.1 G-patch 491..534 CDD:279867 19/42 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11340
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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