DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4896 and Rbm6

DIOPT Version :9

Sequence 1:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001101656.1	Gene:	Rbm6 / 315997	RGDID:	1560367	Length:	1119	Species:	Rattus norvegicus

Alignment Length:	1162	Identity:	239/1162 - (20%)
Similarity:	398/1162 - (34%)	Gaps:	403/1162 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FSGGNG-----NGSESGYRRYSRSRSRSRE-RSRDR--NEYRRRNS------------------- 46
            :.||:|     .|.|:.:..|....|.:.: ||||.  :::|.|.:
  Rat   135 YRGGDGAPIDYRGRETPHINYRDRDSHTADFRSRDAPPSDFRGRGAYDLDFRGRDGSHADFRGRD 199

  Fly    47 ------RSRSRERSSHYRNDRSPDRDLYRDLINEDYEDQGNYNSRQNLDQRHGEDKYDRRHADSQ 105
                  |||.:.||. :||....|.| :||......:.:|..::..:||.|:    .|..|:|.:
  Rat   200 LSDLDFRSRDQSRSD-FRNREVSDLD-FRDKDGAQVDFRGRGSATTDLDFRN----RDAPHSDFR 258

  Fly   106 GRRDHDSNYDKSGQDMD-------------------------KDRDHRWKNYDRVSRERNHD--- 142
            ||....:..|..|:::.                         ::|:|...|.:: ..|..||
  Rat   259 GRHRSRTYQDFRGREVGPCMEFKDREMPPVDPKVLDYIQPPAQEREHSGMNMNK-REESTHDHTV 322

  Fly   143 ----------DFDRGSERSSRSNDQRQFNNNGNS---NSSSSYRDREKER-DRDRRCSSD----- 188
                      :|:. ||..........|.:...|   ||.|..:|::|.: ....:.|||
  Rat   323 ERPAFGVQKGEFEH-SETREGETQSGTFEHESQSDFQNSQSPVQDQDKPKLSAGEQQSSDAGLFK 386

  Fly   189 ----------EDSDMAS------EFRQRGA----------------------------YNSGSSV 209
                      :|:|..|      :.|..|:                            |.:|.|.
  Rat   387 EEGDLDFLGRQDTDYRSMEYCDVDHRLPGSQIFGYGQSKSFPQGKMSRDAQQDLQDQDYRTGPSE 451

  Fly   210 EPLNNII-LFGLKKHVTEADIMGELIKVDLEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWME 273
            |..|.:| |.|:.::.|:.:|:......|..|.....:::..||....:..|||..:|:|...||
  Rat   452 EKPNRLIRLNGVPENATKEEILNAFRTSDGLPVKELQLKEYNTGYDYGYVCVEFSLLEDAIGCME 516

  Fly   274 LTQGVLQLGDHRVTMQYSHTRISDWTCIKCGASNFKRRFQCYMCNASRAE--------------- 323
            ..||.|.:.|..||::|..:. ..|.|.:|.||....:..|..|...:.|
  Rat   517 ANQGTLMIHDKEVTLEYVPSP-DFWYCKRCKASTGGHQSCCSYCKGPKEEVKQELVSYPQPQKTS 580

  Fly   324 ----------------SENALYGAGEGVD--------EISQIL---------------------- 342
                            .|:.|....||.:        |..:..
  Rat   581 IPVPSEKQPNQPRPVDKEHELRKREEGQESRLGHQKRETERYFPHSRREGLTFRRDREKESWSGE 645

  Fly   343 ------TKKIMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSRDALTNASRGICYLNFDTLI 401
                  :|.|||:.:...|..|.::..|:   |.:..|.:.|.:.::..........:::.|:..
  Rat   646 TRQDGESKTIMLKRIYRSTPPEVIVEVLE---PYVHLTTANVRIIKNRTGPMGHTYGFIDLDSHA 707

  Fly   402 DSMNVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMMPAEGNFFRAGETAMSPSAITAAYTLADV 466
            :::.|...|..||||.::|.|.|.|..           |.|.  |..::.
  Rat   708 EALRVVKILQNLDPPFSIDGKMVAVNL-----------ATGK--RRNDSG--------------- 744

  Fly   467 PRLAEYSASVYASNPLEHANYVQYYTDYYTTEISKNCRDRQVTEANSGAAVALSAIQRKQRKVSQ 531
                            :|::::.||      :..|..|||:....||.    .|:...:|.:.|.
  Rat   745 ----------------DHSDHMHYY------QGKKYFRDRRGGNRNSD----WSSDTNRQGQQSS 783

  Fly   532 METTVSVTEAKVAFLARGESAPKGNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYYDAHSQYYYN 596
            .:.                                  |.||..:|||||.:.|.|||.::|
  Rat   784 SDC----------------------------------YIYDSATGYYYDPLAGTYYDPNTQ---- 810

  Fly   597 NETGAYLYWDQKRSTYVLATPASTQAALKEVLADAEKKEEEAKKAKE----KEKEKEEAGGKPDK 657
                        :..||...|.|.:             |||.|:.|.    |...|:|...:..|
  Rat   811 ------------QEVYVPQDPESPE-------------EEEIKEKKSTSQGKSNSKKETSKRDGK 850

  Fly   658 VKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILSDTEAATTSRASQGAYADVGFSILEKKELGK 722
            .|..:.:.|..|..::.....:|......|..:                          |||
  Rat   851 EKKDRGVTKFQESTSEGKPPPEDVFKKPLPPTV--------------------------KKE--- 886

  Fly   723 LNDYVPEAGPP-----AISKLVGAYGGPSDSEDDNSANQ------KALEASVG---TKRAISDES 773
                  |:.||     .:..|:|.|||.||.|::....|      :|.:....   ||:. ::|.
  Rat   887 ------ESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQAPPVQPRAAQPQPREELTKKE-NEED 944

  Fly   774 DYVDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLD---KLKRNPA----VEAGTDEGLSYRD 831
            ...|:.||.||||.|.|.:.::|.||.::|:|||:||:   |:|::..    :|....|| .:::
  Rat   945 KLTDWNKLACLLCRRQFPNKEVLTKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREG-RFKE 1008

  Fly   832 RAKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKDSFGATAAMPI-----SSTNVGSRLMQKM 891
            :..:||.|....|  .|.|.|.::        ||:.||    ...|:     .:::.|....|..
  Rat  1009 KGSDRREKLQSFD--SPERKRIKY--------SRETDS----DRNPVDKEDTDTSSKGGCTQQAT 1059

  Fly   892 GWSEGQGLGKKNQGRTEIIEADGR-SNNVGLGNNTGHMAPGNDYKSYIKKMMKQRYE 947
            ||.:|.|||..:.|.....|.:|| ..:.|....|........|:..::::|..||:
  Rat  1060 GWRKGAGLGYSHPGLGSSEEIEGRMRGSGGAPGRTSKRQSNETYRDAVRRVMFARYK 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	17/104 (16%)
		RRM1_RBM5_like	211..291	CDD:241005	23/80 (29%)
		ZnF_RBZ	296..320	CDD:197784	7/23 (30%)
		RanBP2-type Zn finger	298..317	CDD:275376	6/18 (33%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	21/85 (25%)
		OCRE_RBM5_like	562..617	CDD:293881	15/54 (28%)
		OCRE repeat 1	567..574	CDD:293881	3/6 (50%)
		OCRE repeat 2	575..582	CDD:293881	5/6 (83%)
		OCRE repeat 3	583..590	CDD:293881	4/6 (67%)
		OCRE repeat 4	591..598	CDD:293881	1/6 (17%)
		OCRE repeat 5	600..607	CDD:293881	0/6 (0%)
		G-patch	882..922	CDD:279867	13/40 (33%)
Rbm6	NP_001101656.1	YjbI	<92..251	CDD:224276	28/121 (23%)
		RRM1_RBM6	456..533	CDD:240760	22/76 (29%)
		RRM2_RBM6	651..737	CDD:241007	22/99 (22%)
		OCRE	763..818	CDD:304914	20/108 (19%)
		OCRE repeat 1	769..776	CDD:293880	2/10 (20%)
		OCRE repeat 2	785..792	CDD:293880	3/40 (8%)
		OCRE repeat 3	793..800	CDD:293880	5/6 (83%)
		OCRE repeat 4	801..807	CDD:293880	3/5 (60%)
		OCRE repeat 5	811..818	CDD:293880	2/6 (33%)
		G-patch	1048..1091	CDD:279867	13/42 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13948
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.040