DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4896 and SPAC57A7.13

DIOPT Version :9

Sequence 1:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_593368.1	Gene:	SPAC57A7.13 / 2542526	PomBaseID:	SPAC57A7.13	Length:	565	Species:	Schizosaccharomyces pombe

Alignment Length:	835	Identity:	170/835 - (20%)
Similarity:	272/835 - (32%)	Gaps:	316/835 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 SRSNDQRQFNNNGNSNSSSSYRDREKERDRDRRCSSDEDSDMASEFRQRGAY----NSGSSVE-- 210
            |.:..:..|...|:::|:.|  |....||.|...||| :..:...:|.:|.|    ||..|..
pombe     6 SENGFEEIFEEKGSTSSNIS--DNCASRDYDVNISSD-NPRLLDSYRPKGNYGRDRNSPLSRHIG 67

  Fly   211 -PLNNIILFGLKKHVTEADIMGELIKVDLEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWMEL 274
             |...|||.||...:.|..|...|.....:.:::.::|:::|..||||||.:|.:::::..|||.
pombe    68 VPNQEIILQGLTPEILEEHIELALYATGAKVSTVTLIREKETQKSRCFAFAKFVSLQDSKDWMEA 132

  Fly   275 TQGVLQLGDHRVTMQYSHT---RISDWTCIKCGASNFKRRFQCYMCNASRAESENAL----YGAG 332
            ....|.:....|::::|..   :|..|.|..|...|:..|..|:.|...|.::..|:    ....
pombe   133 NFPTLVIDGIDVSVRFSRAAREQIEGWCCQNCDILNYSYRESCFKCRVPRNQASIAIGNHKISKR 197

  Fly   333 EGVDEISQILTKKIMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSRDALTNASRGICYLNF 397
            .|..::|.:.:..::||.||...:||    .|.:.|.:|...|.:|.:.|....:|..|...|.|
pombe   198 NGDMDVSDVPSVYLILRNLDRSLSEE----TLWKGLSKLEIDVQRVFMIRYKFNDAFCGYAILEF 258

  Fly   398 DTLIDSMNVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMM-----PAEGNFFRAGETAMSPSAI 457
            ..                              :|...:.:|     |.:|
pombe   259 KD------------------------------VDESAKALMKARTYPGKG--------------- 278

  Fly   458 TAAYTLADVPRLAEYSASVYASNPLEHANYVQYYTDYYTTEISKNCRDRQVTEANSGAAVALSAI 522
               :|||
pombe   279 ---FTLA---------------------------------------------------------- 282

  Fly   523 QRKQRKVSQMETTVSVTEAKVAFLARGESAPKGNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYY 587
               .||||                                            ..|.:|.|....|
pombe   283 ---SRKVS--------------------------------------------VDYIHDGVLIPAY 300

  Fly   588 DAHSQYYYNNETGAYLYWDQKR--STYVLATPASTQAALKEVLADAEKKEEEAKKAKEKEKEKEE 650
            ...:::.:..:||..:|||.:.  |.||   |       :.:..|..|..|..||.|   |||..
pombe   301 TESARWQFPTKTGYLVYWDPELYCSIYV---P-------EGIDTDQFKPIEVNKKPK---KEKRA 352

  Fly   651 AGGKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILSDTEAATTSRASQGAYADVGFSIL 715
            .......|..:||:...:::|                    :|.:
pombe   353 RSSNYIDVPASKKVATSLQRW--------------------NDAQ-------------------- 377

  Fly   716 EKKELGKLNDYVPEAGPPAISKLVGAYGGPSDSEDDNSANQKALEASVGTKRAISDESD-----Y 775
              ||   |.|.:|:                                       :|:|.:     :
pombe   378 --KE---LKDNIPD---------------------------------------LSEEEEKLLLHF 398

  Fly   776 VDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLDKLKRNPAVEAG--------TDEGLSYRDR 832
            |....|.|:||.|.|||...:.||:..|.:|..|   ||.:..|.:.        ..|.:.||||
pombe   399 VWKSALICVLCERKFQSWGHVVKHITQSIMHNNN---LKNHELVSSAELLMHRVRQTESVDYRDR 460

  Fly   833 AKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKDSFGATAAMPISSTNVGSRLMQKMGWSEGQ 897
            |.|||:        .|..|.:..   ::..:|.|..||.:|       :||..:::..|||::|.
pombe   461 ATERRI--------VPAASSDTI---VEAKKSSQGSSFHST-------SNVSMKMLNSMGWNKGS 507

  Fly   898 GLGKKNQGRTEIIEADGRSNNVGLGNNTG----HMAPGNDYKSYIKKMMKQRYEN 948
            |||....|..|.|:.......|||||...    :|.|.:..|...:.:..|..:|
pombe   508 GLGTNENGIKEAIQPTMYLPGVGLGNKGSKIQINMTPVDRVKDRARSLYFQNDKN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	1/5 (20%)
		RRM1_RBM5_like	211..291	CDD:241005	23/79 (29%)
		ZnF_RBZ	296..320	CDD:197784	7/23 (30%)
		RanBP2-type Zn finger	298..317	CDD:275376	6/18 (33%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	16/85 (19%)
		OCRE_RBM5_like	562..617	CDD:293881	12/56 (21%)
		OCRE repeat 1	567..574	CDD:293881	0/6 (0%)
		OCRE repeat 2	575..582	CDD:293881	2/6 (33%)
		OCRE repeat 3	583..590	CDD:293881	1/6 (17%)
		OCRE repeat 4	591..598	CDD:293881	0/6 (0%)
		OCRE repeat 5	600..607	CDD:293881	3/6 (50%)
		G-patch	882..922	CDD:279867	14/39 (36%)
SPAC57A7.13	NP_593368.1	RRM1_RRM2_RBM5_like	69..149	CDD:240759	23/79 (29%)
		RRM	211..281	CDD:214636	20/121 (17%)
		G-patch	490..534	CDD:279867	17/50 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I1069
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		otm47280
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1777
SonicParanoid	1	1.000	-	-		X1642
TreeFam	0	0.000	Not matched by this tool.
	9	8.990