DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4896 and Rbm10

DIOPT Version :9

Sequence 1:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_663602.1	Gene:	Rbm10 / 236732	MGIID:	2384310	Length:	930	Species:	Mus musculus

Alignment Length:	1042	Identity:	327/1042 - (31%)
Similarity:	469/1042 - (45%)	Gaps:	246/1042 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EYRRRNSRSRSRERSSHY-RNDRSPDRDLYRDLINEDYEDQGNYNSR----QNLDQRHGEDKYDR 99
            ||.||..|.   :|:..| ..|||.|             |.|...||    :::|.|    .|.|
Mouse     2 EYERRGGRG---DRTGRYGATDRSQD-------------DSGENRSRDHDYRDMDYR----SYPR 46

  Fly   100 RHADSQGRRDHDSNYDKSGQDMDKDRDHRWKNYDRVSRERNHDDFDRGSERSSRSNDQRQFNNNG 164
            .:...:|:.:                      ||..|.|::.:|....|..|.....:|:.:.:.
Mouse    47 EYGSQEGKHE----------------------YDDSSEEQSAEDSYEASPGSETQRRRRRRHRHS 89

  Fly   165 NSNSSSSYRDREKERDRDRRCSSDEDSDMASEFRQRGAYNSGSSVEPLNNIILFG-LKKHVTEAD 228
            .:......||.: .||:|.|....|:.:...|..:.         |..:||::.. |.:..||.|
Mouse    90 PTGPPGFPRDGD-YRDQDYRTEQGEEEEEEDEEEEE---------EKASNIVMLRMLPQAATEDD 144

  Fly   229 IMGELIKVDLEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWMELTQGVLQLGDHRVTMQYSHT 293
            |.|:|....::...:|:||.:.:|.||.||||||..:::||||||..|..|.:...:|:|.||..
Mouse   145 IRGQLQSHGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDP 209

  Fly   294 R---ISDWTCIKCGASNFKRRFQCYMCNASRAESENALYGAGEGVD---------EISQ------ 340
            :   ..||.|.|||..|||||.:|:.|...::|:|..| ..|..:|         |:||
Mouse   210 KPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKL-PLGTRLDQQALPLGGRELSQGLLPLP 273

  Fly   341 -------ILTKK----------------IMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSR 382
                   :||.:                |:||.|:..:..:.:|.||   .|....:.|.|.|.:
Mouse   274 QPYQAQGVLTSQALSQGSEPSSENANDTIILRNLNPHSTMDSILGAL---APYAVLSSSNVRVIK 335

  Fly   383 DALTNASRGICYLNFDTLIDSMNVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMMPAEGNFFRA 447
            |..|..:||..::...|::::..:...|.||.||||:|.||:.|.:...|: |.|...||:  |.
Mouse   336 DKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSK-RDMASNEGS--RI 397

  Fly   448 GETAMSPSAITAA-YTLADVPRLAEYSASVYASNPLEHANYVQ-------YYTD-YYTTEISKNC 503
            ...:::.:||.|| :.::...:..|.:.:.....|::::.|.|       ..|| .|.....||.
Mouse   398 NAASVASTAIAAAQWAISQASQGGESAWAAPEEPPVDYSYYQQDEGYGSSQGTDSLYAHGYLKNS 462

  Fly   504 RDRQVT-----------EAN--SGA-AVALSAIQRKQRKV--------------------SQMET 534
            :...:|           ||:  :|| :|:|.|..|.|...                    ||..|
Mouse   463 KGPGMTGTKGDPAGTGPEASLEAGADSVSLQAFSRAQPGAAPGLYQQSAEGSSGQSTATNSQSYT 527

  Fly   535 TVS--VTEAKV---------AF-LARGESAPKGNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYY 587
            .:|  |.:|::         || .|...:||:..  .:|..||||.||||||||||||..|||||
Mouse   528 IISPAVLKAELQSPTQPSSSAFPPATSPTAPEAY--SQYPVPDVSTYQYDETSGYYYDPQTGLYY 590

  Fly   588 DAHSQYYYNNETGAYLYWDQKRSTYVLATPASTQAALKEVLADAEKKEEEAKKAKEKEKEKEEAG 652
            |.:||||||.::..|||||.:|.||:   ||..|:      ||..|....:.|..:::|||.
Mouse   591 DPNSQYYYNAQSQQYLYWDGERRTYI---PALEQS------ADGHKDTGASSKEGKEKKEKH--- 643

  Fly   653 GKPDKVKVAKKIVKDMEKWAKQLN-QKKDYTAVATPQPILSDTEAATTSRASQGAYADVGFSILE 716
                |.|.|::|.||||:||:.|| ||:::.....|...|.|.|      ..:.|.||.|::|||
Mouse   644 ----KTKTAQQIAKDMERWARSLNKQKENFKNSFQPISALRDDE------RRESATADAGYAILE 698

  Fly   717 KK-----------ELGKL-NDYVPEAGPPAISKLVGAYGGPSDSEDDNSANQKALEASVGTKRAI 769
            ||           :|.|| :|..|  .||  ..||.||.|.||||::....        |.:|
Mouse   699 KKGALAERQHTSMDLPKLASDDRP--SPP--RGLVAAYSGESDSEEEQERG--------GPER-- 749

  Fly   770 SDESDYVDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLD-----KLKRN--PAVEAGTDEGL 827
              |....|:|||.||||.|.|.|.:.|.:|.::|.|||:||:     .|..|  .|:|....|.:
Mouse   750 --EEKLTDWQKLACLLCRRQFPSKEALIRHQQLSGLHKQNLEIHRRAHLSENELEALEKNDMEQM 812

  Fly   828 SYRDRAKERRLKYGESDPPPPNRSR--------ERFEQEIKTLQSRQKDSFGATAAMPISSTNVG 884
            .|||||.|||.|||..:||.|.|.:        ..|||.       .:|..|        |.|:|
Mouse   813 KYRDRAAERREKYGIPEPPEPKRRKYGGISTASVDFEQP-------TRDGLG--------SDNIG 862

  Fly   885 SRLMQKMGWSEGQGLGKKNQGRTEIIEADGRSNNVGLG--NNTGHMAPGNDYKSYIKKMMKQRYE 947
            ||::|.|||.||.|||:|.||....|||..|....|||  .::..:.....||..:.|.|..|:.
Mouse   863 SRMLQAMGWKEGSGLGRKKQGIVTPIEAQTRVRGSGLGARGSSYGVTSTESYKETLHKTMVTRFN 927

  Fly   948 NA 949
            .|
Mouse   928 EA 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	11/66 (17%)
		RRM1_RBM5_like	211..291	CDD:241005	31/80 (39%)
		ZnF_RBZ	296..320	CDD:197784	13/23 (57%)
		RanBP2-type Zn finger	298..317	CDD:275376	11/18 (61%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	28/101 (28%)
		OCRE_RBM5_like	562..617	CDD:293881	36/54 (67%)
		OCRE repeat 1	567..574	CDD:293881	5/6 (83%)
		OCRE repeat 2	575..582	CDD:293881	6/6 (100%)
		OCRE repeat 3	583..590	CDD:293881	6/6 (100%)
		OCRE repeat 4	591..598	CDD:293881	6/6 (100%)
		OCRE repeat 5	600..607	CDD:293881	4/6 (67%)
		G-patch	882..922	CDD:279867	21/39 (54%)
Rbm10	NP_663602.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		37/176 (21%)
		RRM	21..>232	CDD:223796	73/259 (28%)
		RRM1_RBM10	127..211	CDD:241197	33/83 (40%)
		ELAV_HUD_SF	136..381	CDD:273741	81/248 (33%)
		ZnF_RBZ	215..239	CDD:197784	13/23 (57%)
		RanBP2-type Zn finger	217..236	CDD:275375	11/18 (61%)
		RRM2_RBM10	298..384	CDD:241198	27/88 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..487		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..522		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..566		6/30 (20%)
		OCRE_RBM10	564..627	CDD:293886	42/71 (59%)
		OCRE repeat 1	570..577	CDD:293886	5/6 (83%)
		OCRE repeat 2	578..585	CDD:293886	6/6 (100%)
		OCRE repeat 3	586..593	CDD:293886	6/6 (100%)
		OCRE repeat 4	594..601	CDD:293886	6/6 (100%)
		OCRE repeat 5	603..610	CDD:293886	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..753		19/56 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..861		17/57 (30%)
		G-patch	858..902	CDD:279867	24/43 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843022
Domainoid	1	1.000	124	1.000	Domainoid score	I5489
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31330
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2109
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55750
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	1	1.000	-	-		FOG0002462
OrthoInspector	1	1.000	-	-		mtm8864
orthoMCL	1	0.900	-	-		OOG6_102541
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1777
SonicParanoid	1	1.000	-	-		X1642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940