DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4896 and Rbm6

DIOPT Version :9

Sequence 1:	NP_608583.5	Gene:	CG4896 / 33305	FlyBaseID:	FBgn0031319	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_035381.2	Gene:	Rbm6 / 19654	MGIID:	1338037	Length:	1118	Species:	Mus musculus

Alignment Length:	1162	Identity:	240/1162 - (20%)
Similarity:	404/1162 - (34%)	Gaps:	404/1162 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FSGGNG-----NGSESGYRRYSRSRS------RSRE------------------RSRDRNEYRRR 44
            :.||:|     .|.|:.:..| |.|.      |||:                  |....:::|.|
Mouse   135 YRGGDGTPMDYRGRETPHMNY-RDRDSHTVDFRSRDVPPTDFRGRGTYDLDFRGREGSHSDFRGR 198

  Fly    45 NSRS---RSRERS-SHYRNDRSPDRDLYRDLINEDYEDQGNYNSRQNLDQRHGEDKYDRRHADSQ 105
            :...   |||::| |.:||....|.| :||......:.:|..::..:||.|:    .|..|:|.:
Mouse   199 DLSDLDFRSRDQSRSDFRNRDVSDLD-FRDKDGTQVDFRGRGSATTDLDFRN----RDTPHSDFR 258

  Fly   106 GRRDHDSNYDKSGQDMD-----KDR-----DHRWKNYDRVS-RERNHDDF----------DRGSE 149
            ||....:..|..|:::.     |||     |.:..:|.:.| :||.|...          |...|
Mouse   259 GRHRTRTYQDFRGREVGPCMEFKDREMPPMDPKVLDYIQPSPQEREHSGMNMNKREESIHDHAME 323

  Fly   150 RSSRSNDQRQFNNN----GNS-------NSSSSYRDRE---KERDRDRRCSSDEDSDMASEFRQR 200
            |.:....:.:|.::    |.:       .|.|.:::.:   :|:|:.:....::.|..|..|::.
Mouse   324 RPAFGVQKGEFEHSETREGETQSGTFEHESQSDFQNSQSPVQEQDKPKLSGGEQQSSDAGLFKEE 388

  Fly   201 G------------------------------------------------------AYNSGSSVEP 211
            |                                                      .|.:|.|.|.
Mouse   389 GDLDFLGQQDTDYRSIEYCDVDHRLPGNQIFGYGQSKSFSQGKMSRDAQQDLQDQDYRTGPSEEK 453

  Fly   212 LNNII-LFGLKKHVTEADIMGELIKVDLEPTSIRVMRKQQTGASRCFAFVEFKTVEEATRWMELT 275
            .|.:| |.|:.::.|:.:|:......|..|.....:::..||....:..|||..:|:|...||..
Mouse   454 PNRLIRLSGVPENATKEEILNAFRTSDGIPVKDLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEAN 518

  Fly   276 QGVLQLGDHRVTMQYSHTRISDWTCIKCGASNFKRRFQCYMCNASRAESENAL------------ 328
            ||.|.:.|..||::|..:. ..|.|.:|.||....:..|..|...:.|.:..|
Mouse   519 QGTLMIHDKEVTLEYVPSP-DFWYCKRCKASTGGHQSSCSFCKGPKEEVKQELVSYPQPQKTSIP 582

  Fly   329 ------------------------------------------YGAGEGV-------------DEI 338
                                                      :...||:             |..
Mouse   583 VPSEKQPNQPRPADKEHELRKREEGQESRLGHQKRDTERYFPHSRREGLTFRRDREKEPWSGDSR 647

  Fly   339 SQILTKKIMLRGLDALTNEEGVLTALQQRLPELAKTVSKVLVSRDALTNASRGICYLNFDTLIDS 403
            ....:|.|||:.:...|..|.::..|:   |.:..|.:.|.:.::..........:::.|:..::
Mouse   648 QDGESKTIMLKRIYRSTPPEVIVEVLE---PYVHLTTANVRIIKNRTGPMGHTYGFIDLDSHAEA 709

  Fly   404 MNVFNGLTALDPPLTLDDKTVIVTYCIDSENRQMMPAEGNFFRAGETAMSPSAITAAYTLADVPR 468
            :.|...|..||||.::|.|.|.|..           |.|.  |..::.
Mouse   710 LRVVKILQNLDPPFSIDGKMVAVNL-----------ATGK--RRNDSG----------------- 744

  Fly   469 LAEYSASVYASNPLEHANYVQYYTDYYTTEISKNCRDRQVTEANSGAAVALSAIQRKQRKVSQME 533
                          :|::::.||      :..|..|||:....||.    .|:...:|.:.|..:
Mouse   745 --------------DHSDHMHYY------QGKKYFRDRRGGNRNSD----WSSDTNRQGQQSSSD 785

  Fly   534 TTVSVTEAKVAFLARGESAPKGNDGKKYDTPDVSKYQYDETSGYYYDHVTGLYYDAHSQYYYNNE 598
            .                                  |.||.|:|||||.:.|.|||.::|
Mouse   786 C----------------------------------YIYDSTTGYYYDPLAGTYYDPNTQ------ 810

  Fly   599 TGAYLYWDQKRSTYVLATPAS-TQAALKEVLADAEKKEEEAKKAKEKE-KEKEEAG--------- 652
                      :..||...|.| .:..:||..:.::.|....|:..::: |||::.|
Mouse   811 ----------QEVYVPQDPESPDEEEIKEKKSTSQGKSNSKKETSKRDGKEKKDRGMTKFQESTS 865

  Fly   653 -GKPDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPILSDTEAATTSRASQGAYADVGFSILE 716
             |||....|.||.:....|       |::     :|.|
Mouse   866 EGKPPLEDVFKKPLPPTVK-------KEE-----SPPP--------------------------- 891

  Fly   717 KKELGKLNDYVPEAGPPAISKLVGAYGGPSDSEDDNSANQ-------KALEASVGTKRAISDESD 774
                       |:...|.|. |:|.|||.||.|::....|       .|......||:...|:.
Mouse   892 -----------PKVVNPLIG-LLGEYGGDSDYEEEEEEEQAPPVQPRTAQPREEMTKKENEDDK- 943

  Fly   775 YVDFQKLTCLLCMRAFQSLDILQKHLKMSNLHKENLD---KLKRNPA----VEAGTDEGLSYRDR 832
            ..|:.||.||||.|.|.:.::|.||.::|:|||:||:   |:|::..    :|....|| .::::
Mouse   944 LTDWNKLACLLCRRQFPNKEVLTKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREG-RFKEK 1007

  Fly   833 AKERRLKYGESDPPPPNRSRERFEQEIKTLQSRQKDSFGATAAMPI-----SSTNVGSRLMQKMG 892
            ..:||.|....|  .|.|.|.::        ||:.||    ...|:     .:::.|....|..|
Mouse  1008 GNDRREKLQSFD--SPERKRIKY--------SRETDS----DRNPVDKEDTDTSSKGGCAQQATG 1058

  Fly   893 WSEGQGLGKKNQGRTEIIEADGRSNNVGLG--NNTGHMAPGNDYKSYIKKMMKQRYE 947
            |.:|.|||..:.|.....|.:||....|.|  ..|........|:..::::|..||:
Mouse  1059 WRKGAGLGYSHPGLGSSEEIEGRMRGPGGGPPGRTSKRQSNETYRDAVRRVMFARYK 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4896	NP_608583.5	DUF1777	91..>158	CDD:285811	20/87 (23%)
		RRM1_RBM5_like	211..291	CDD:241005	23/80 (29%)
		ZnF_RBZ	296..320	CDD:197784	7/23 (30%)
		RanBP2-type Zn finger	298..317	CDD:275376	6/18 (33%)
		RRM1_RRM2_RBM5_like	343..429	CDD:240759	21/85 (25%)
		OCRE_RBM5_like	562..617	CDD:293881	16/54 (30%)
		OCRE repeat 1	567..574	CDD:293881	3/6 (50%)
		OCRE repeat 2	575..582	CDD:293881	5/6 (83%)
		OCRE repeat 3	583..590	CDD:293881	4/6 (67%)
		OCRE repeat 4	591..598	CDD:293881	1/6 (17%)
		OCRE repeat 5	600..607	CDD:293881	0/6 (0%)
		G-patch	882..922	CDD:279867	13/39 (33%)
Rbm6	NP_035381.2	Pentapeptide_4	173..235	CDD:404485	14/62 (23%)
		RRM1_RBM6	456..533	CDD:409753	22/76 (29%)
		RRM2_RBM6	651..737	CDD:409979	22/99 (22%)
		OCRE_RBM6	763..828	CDD:293882	23/118 (19%)
		OCRE repeat 1	769..776	CDD:293882	2/10 (20%)
		OCRE repeat 2	785..792	CDD:293882	3/40 (8%)
		OCRE repeat 3	793..800	CDD:293882	5/6 (83%)
		OCRE repeat 4	801..807	CDD:293882	3/5 (60%)
		OCRE repeat 5	811..818	CDD:293882	2/6 (33%)
		G-patch	1046..>1079	CDD:396249	10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950